CEO @ MusiQ Bio Having some fun and getting things done.
Joined April 2021
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Update: After defending my Ph.D. last year, I finally walked at commencement this month and was hooded by my advisor, @JerzySzablowski , who also recently celebrated his well-deserved tenure promotion!
With that, my “super alright” time at Rice University comes to a close. 1/4
Manwal Harb retweeted
MusiQ Bio, co-founded by Rice Bioengineering alumnus Manwal Harb, has received a $2.6 million grant from @CPRITTexas for a project that will advance immunotherapy for breast cancer. ow.ly/wp3750ZO5UG
Manwal Harb retweeted
Excited to introduce LUNAR - an engineered receptor that enables arbitrary cells to sense extracellular DNA and triggers a direct transcriptional readout, WITHOUT compromising the cell membrane! 🌚🧫🧬🔑🧪🌟🌝
Have a preview 👀 of our manuscript on bioRxiv biorxiv.org/content/10.64898…
Controlling the transcription with the DNA… that stays outside of the cell? Introducing LUNAR, a chemogenetic receptor gated by DNA for sensing applications. This complex project was led by @BoaoXia with collaborators @aliceyting and @nkalogriopoulos.
biorxiv.org/content/10.64898…
Manwal Harb retweeted
Controlling the transcription with the DNA… that stays outside of the cell? Introducing LUNAR, a chemogenetic receptor gated by DNA for sensing applications. This complex project was led by @BoaoXia with collaborators @aliceyting and @nkalogriopoulos.
biorxiv.org/content/10.64898…
Manwal Harb retweeted
qPCR allowed us to measure transcripts, but just once, destructively, and only in post-mortem tissues. Here, we show we can record transcript level history in vivo and recover this information with a blood test to make a "noninvasive qPCR". nature.com/articles/s41467-0…
Manwal Harb retweeted
Tenure.
Deeply grateful to the students, postdocs, mentors, collaborators, and colleagues who made this possible. The next chapter will expand the lab towards a couple of new directions. The first grant for one of them just went out this morning :).
To adapt a saying from a wise man, “projects come and go, but my people stay eternal.” I’ve been fortunate enough to work alongside incredible lab members and peers, both current and past, and I’m confident there are more amazing times ahead for all of us. 3/4
As for what’s next, I’m now serving as CEO of MusiQ Bio (musiqbio.com), a preclinical-stage biotech company using sound science to deliver drugs past biological barriers. Excited to share more soon! 4/4
Manwal Harb retweeted
Congrats Dr @ManwalHarb, our lab's 3rd Ph.D. graduate. Dr. Harb defended last year, and joined us for the commencement. Since then he co-founded a focused ultrasound company musiqbio.com/ where he is a CEO. I am told to watch for exciting news about this newco soon 👀
Manwal Harb retweeted
Congrats to @ManwalHarb and the rest of the team. Our paper on targeting spatially-defined projections with AAV9.retro with focused ultrasound is now published. We quantified transduction and found that ultrasound can match efficiency of invasive delivery
aiche.onlinelibrary.wiley.co…
Manwal Harb retweeted
Excited to share my recent work on erasable synthetic serum markers-engineered RMAs with a controllable half-life to reduce background noise and enable sensitive, high-temporal-resolution monitoring of brain gene expression, all with a simple blood test!🧠🩸
Manwal Harb retweeted
Usually serum markers are detected as they are - often hard to detect, long half-life, or with high background that reduces temporal resolution. What if we could modify the markers in vivo so they can better match our needs? Introducing this concept with erasable serum markers.
Manwal Harb retweeted
Dr. Harb's projects that he led or contributed are listed below:
biorxiv.org/content/10.1101/…
biorxiv.org/content/10.1101/…
nature.com/articles/s41467-0…
biorxiv.org/content/10.1101/…
szablowskilab.org/publicatio…
Manwal Harb retweeted
PhD #3 - Dr. Manwal Harb who helped to develop the first engineered AAV for focused ultrasound delivery, evaluated a retrograde-tracing AAV9 for noninvasive targeting of neuronal projections, and contributed to other projects. He will move on to be a CEO of a stealth startup.
Excited to talk about how we used a retrograde-tracing viral vector for noninvasive transduction of neuronal projections at my upcoming defense!
Grateful for the support of my lab mate @Shinouraein and my advisor @JerzySzablowski.
Manwal Harb retweeted
A new Ph.D from our lab! Congrats to Dr. Joon Pyung Seo. Dr. Seo established REMIS for measuring gene expression in the brain with spatial precision, contributed to the developing site-specific brain therapeutics, and enabled a clinical trial through his data. Links in comments
Awesome talks happening at the @Rice_BIOE retreat, especially from my lab colleague, Dr. Sho Watanabe @alfort_123
Sho Watanabe of the @JerzySzablowski Lab presents research on “Noninvasive ‘qPCR’ - Measurement of Deep Tissue Transfription with a Blood Test” at the 2025 retreat!
Manwal Harb retweeted
Sho Watanabe of the @JerzySzablowski Lab presents research on “Noninvasive ‘qPCR’ - Measurement of Deep Tissue Transfription with a Blood Test” at the 2025 retreat!
Manwal Harb retweeted
We are starting our
@ARIA_research
Precision Neurotechnologies project and have two postdoc positions in neuroscience and bioengineering. This funding is independent of US government. Jobs: emdz.fa.us2.oraclecloud.com/…… More info: tinyurl.com/hwsnrwpe -- please RT --