@MarcelArias

Futur obscur, idees clares. Cancer Immunologist.

Joined March 2010
  • Tweets2.3K
  • Following230
  • Followers252
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Marcel Arias retweeted
UC San Francisco@UCSFAug 27
What if doctors could use your own tumor to teach your immune system to destroy cancer? UCSF scientists may have found a way. By coating lab-grown immune cells with pieces of a patient’s own tumor, they trained T cells to recognize and attack the cancer. ucsf.edu/news/2026/08/432431…

How to Teach T Cells to Track Cancer Like a Hound Dog

Scientists made universal stem-cell-derived dendritic "immune teacher" cells that can be coated with a patient’s tumor proteins, creating a cancer vaccine that activated tumor-killing T cells in...

ucsf.edu
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A highlight from last week: Can routine archived clinical biopsies help predict treatment response in ulcerative colitis? doi.org/10.1172/JCI202488 @MikeKattahMD, @alexis_combes & team @UCSFMedicine applied spatial gene mapping to archived colitis biopsies, identifying immune cell neighborhoods that explain why some patients are resistant to vedolizumab and others respond well. @MayoClinic #Colitis #IBD
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📢 PhD position open at #VHIO 🧑‍🔬 Join the Cell Engineering and Hematologic Immunotherapy Group, led by Pere Barba, and work on: 🧬 Cellular immunotherapy 🩸 CAR T-cell biology 🔬 Genomics 🎯 Translational cancer research 🗓️ Deadline: 26/06 Apply 👇 jobs.vhio.net/en/jobs/790106…
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Marcel Arias retweeted
Gita Gopinath
@GitaGopinathMay 14
A painting of the end of meritocracy: A meeting of the two largest economies and not one woman at the table.
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Marcel Arias retweeted
Waggoner Lab@LabWaggonerJan 25
Intratumoral CD4+CD8+ T cells can serve as precursors to single positive T cells in vivo via Rag2 expression, suggesting that tumors act as extrathymic sites of T cell development @UCSF pnas.org/doi/10.1073/pnas.25…
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Marcel Arias retweeted
UC San Francisco@UCSF21 Aug 2025
Not only does UCSF's NIH-funded research advance health care and improve patients' lives, it has an estimated $18.7B ripple effect on the economy. The result is more innovative startups, more jobs, and stronger companies that hire workers nationwide. tiny.ucsf.edu/SavingLivesWit…
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Marcel Arias retweeted
Waggoner Lab@LabWaggoner7 Aug 2025
Review @JExpMed @lawfong CD4+ T cell dysfunction in cancer rupress.org/jem/article/222/…
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Marcel Arias retweeted
IDIBAPS@idibaps10 Jun 2025
La Vanguardia entrevista la investigadora de l'#IDIBAPS @GuedanS, finalista dels premis La Vanguardia de la ciencia.  La pots votar en aquest enllaç 👉f.mtr.cool/gahnvtuxow
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Marcel Arias retweeted
IDIBAPS@idibaps26 May 2025
🗞️Sònia Guedán (@GuedanS), cap de grup de l'#IDIBAPS, entre les 8️⃣ finalistes al premi Vanguardia de la Ciència Una iniciativa de @LaVanguardia i la @FCLP_Fundacio per visibilitzar dones científiques i reduir la bretxa de gènere en la recerca 👉f.mtr.cool/yyawblwnpe
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🔬Our latest study from the Ashkenazi lab at @genentech reveals a previously unrecognized mechanism of IRE1 signaling. This discovery redefines current models and introduces a new framework for therapeutic targeting in cancer. 📖 Read more: journals.plos.org/plosbiolog…

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and...

ER-resident IRE1 is known to play a role in cancer development through its enzymatic activation of XPB1 transcription factors and of regulated RNA decay. This study shows that some cancer cells also...

journals.plos.org
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Tumor localized CTLA4 blockade using a cleavable, conditionally activatable DVD IgG provides primary antigen-specific anti tumor efficacy in localized and systemic preclinical tumor models! Thanks as always to @MarcelArias @lawfong for the mentorship! jitc.bmj.com/content/13/4/e0…

Impact of tumor localization on antitumor immunity with conditionally activated CTLA-4 blockade

Background Immune checkpoint blockade (ICB) can induce antitumor efficacy but also induces immune-related adverse events. Systemically administered ICB can activate immune cells throughout the host....

jitc.bmj.com
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New #JITC article: Impact of tumor localization on antitumor immunity with conditionally activated CTLA-4 blockade bit.ly/42zatca @MarcelArias @UCSF
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Think global, act local! Just like the fully cleavable, conditionally activatable DVD CTLA4 blockade we report at jitc.bmj.com/content/13/4/e0… ! It provided safe, primary antigen-specific antitumor efficacy in localized and systemic preclinical tumor models. @lawfong

Impact of tumor localization on antitumor immunity with conditionally activated CTLA-4 blockade

Background Immune checkpoint blockade (ICB) can induce antitumor efficacy but also induces immune-related adverse events. Systemically administered ICB can activate immune cells throughout the host....

jitc.bmj.com
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🎭 This Friday, March 28, our #UCSF #improv group is hitting the stage at @TheLostChurchSF! A bunch of #scientists doing improv—what could go wrong? (Or very right 😄) Expect laughs, chaos, and a great show! 🎟️ Grab your tickets here: thelostchurch.my.salesforce-…
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#StandUpForScience2025 if you'd like a healthier future for humanity
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Me hace mucha ilusión haber recibido el reconocimiento al mejor artículo científico de 2024 junto a @GuedanS y @fara_bm durante el segundo #EncuentroInvestigadoresAECC. Fue una jornada increíble rodeada de colegas y amigos. Muchas gracias @contracancerINV por vuestro apoyo! 💚
Contra el Cáncer Investigación@contracancerINV4 Mar 2025
🏆🔬 En el #EncuentroInvestigadoresAECC celebramos la excelencia en la investigación oncológica con los Reconocimientos AECC. ¡Felicidades a los ganadores! 1. Guillermo del Cárcer @GdC_CCCB_lab de @IIBmCSICUAM por su labor de divulgación científica 2. @amaia_cipitria de @biogipuzkoa por el mejor pitch de ideas innovadoras 2025 3. @a_diazguerra de @CNIC_CARDIO por el mejor artículo científico de 2024 de entre los adjudicatarios de Ayudas Predoctorales AECC. 4. @GuedanS, Alba Rodríguez y @fara_bm de @idibaps - @hospitalclinic por el mejor artículo científico de 2024 de entre los adjudicatarios de Ayudas Generales AECC #InvestigandoEnCáncer
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In this fantastic collaboration with Abbvie we were able to find time-sensitive synergistic effects between immune checkpoint blockade and JAK1 inhibition in boosting T cell fitness against tumors in mice. Online today! insight.jci.org/articles/vie… @lawfong
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Marcel Arias retweeted
AACR
@AACR24 Feb 2025
Aram Lyu, Peiqi Ou, Helen Rizos, and Annette Paschen discuss "Cancer Immune Evasion" in a symposium at the AACR IO Conference on Discovery and Innovation in Cancer Immunology. #AACRIO25 @HelenRizos @AramLyu
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A multi-institutional team led by @lawfong (former Co-Director of the PICI Center at @UCSF, now at @fredhutch) published a new PICI-funded study in @CCR_AACR exploring nivolumab-based combination therapies in metastatic castration-resistant prostate cancer (mCRPC). (1/3)
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Does a cell’s gene expression always reflect its function? Evidence from zebrafish neurons suggests that transcriptionally similar cells can be functionally diverse @Nature @IShainer @BaierLab nature.com/articles/s41586-0… nature.com/articles/d41586-0… @ClaudeDesplan

Transcriptomic neuron types vary topographically in function and morphology

Nature - Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of...

nature.com
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