@MarderLab

Eve Marder's lab at Brandeis University

 Brandeis University
blogs.brandeis.edu/marderlab/
Joined December 2015
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Very happy to see out work on neuronal homeostasis published in PNAS! Yay! I am very proud and happy to finally contribute to my favorite line of research in the Marder Lab. pnas.org/doi/10.1073/pnas.22…

Gating of homeostatic regulation of intrinsic excitability produces cryptic long-term storage of...

Neurons and neuronal circuits must maintain their function throughout the life of the organism despite changing environments. Previous theoretical ...

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pip install currentscape github.com/BlueBrain/Current… elifesciences.org/articles/4…
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Here's our new paper relating neuronal morphology and robustness in output to changes ion channel densities! doi.org/10.1073/pnas.2219049…

Neuronal morphology enhances robustness to perturbations of channel densities | PNAS

Biological neurons show significant cell-to-cell variability but have the striking ability to maintain their key firing properties in the face of u...

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New review paper from the @MarderLab! Latest insights from small rhythmic neural circuits on individual variability, resilience and neuromodulation of neurons and neural networks. sciencedirect.com/science/ar…
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If you are attending #FENS come see @ThiagoBurghi poster featuring collaborative work between @Timothy0Leary lab and @MarderLab on estimating models of neuronal dynamics using ANN to predict and control the behavior of biological neurons in real-time. S05-513, July 12, 9:30-13:00
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How does climate change affect nervous systems? Read our new review to find out! @grassfoundation @SfNJournals jneurosci.org/content/jneuro…
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New paper out in @eLife by superstar postdoc @neurochart! Reciprocally inhibitory circuits operating with distinct mechanisms are differently robust to perturbation and modulation
Katya Morozova@neurochart7 Mar 2022
In the positive news, our paper is out in @eLife! Read about how the mechanism of oscillation affects neural circuits' resilience to perturbations and neuromodulation. @MarderLab elifesciences.org/articles/7…
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In the positive news, our paper is out in @eLife! Read about how the mechanism of oscillation affects neural circuits' resilience to perturbations and neuromodulation. @MarderLab elifesciences.org/articles/7…
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Motor neurons in the crab stomach innately respond to blue light! Read about it in our latest paper sciencedirect.com/science/ar…
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#SfN21 Albert & Ellen Grass Lecture today at 3:30 pm (ET) | From the Neuroscience of Individual Variability to Climate Change Read the accompanying review by Eve Marder & Mara Rue in #JNeurosci jneurosci.org/lookup/DOI/10.…
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Pairs of neurons that inhibit each other can form simple oscillators with complicated underpinnings which make them differently robust to external influences. Read about our hybrid neuronal circuits that reveal these dynamics!
Katya Morozova@neurochart20 Sep 2021
Happy to share our new preprint describing the features underlying robustness of reciprocally inhibitory circuits to alterations in circuit parameters, temperature, and neuromodulation. @MarderLab biorxiv.org/cgi/content/shor…
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Compartment-based modeling reveals interactions of diameter, myelination, and the Na/K pump activity to determine the reliability of high-frequency spike propagation in axons. Read about it here:pnas.org/content/118/32/e210…

Interactions among diameter, myelination, and the Na/K pump affect axonal resilience to high-freq...

Axons reliably conduct action potentials between neurons and/or other targets. Axons have widely variable diameters and can be myelinated or unmyel...

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Today, #Neuromatch CN students are learning about dynamic networks. For that, our artist and volunteer Katya Morozova (@neurochart) has created this amazing illustration to be the cover for the day. Check out her Instagram channel for even more sciency art 🔬🖼
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Executable Research Articles (ERAs) are changing how we publish science at eLife, letting authors share code interactively in their papers. Hear about authors’ experiences with this truly web-native format: elifesciences.org/labs/51777…
"We put together a Jupiter notebook to make our results and figures easily reproducible, but for us it wasn't enough." Matteo Mancini, author of an interactive meta-analysis of MRI biomarkers of myelin.

ALT "We put together a Jupiter notebook to make our results and figures easily reproducible, but for us it wasn't enough." Matteo Mancini, author of an interactive meta-analysis of MRI biomarkers of myelin.

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We're proud and excited to support reproducible research with our latest project! Here's what it means: 1. You can download the data needed to make figures right now! 2. You can download ALL the analysis code, scripts written for this project from Github Thread, links below ⬇️
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The days of "data/code available on request" *should* be behind us!
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But wait, there's more! We've made the *full* history of all git repositories public -- no more splat commits with "initial commit" messages being the only thing you see. All the failed attempts, alternate directions, interesting but flawed ideas are out there for all to see.
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Mapping circuit dynamics during function and dysfunction: we embedded spike patterns from 400+ circuits to create a map of circuit dynamics under a a broad variety of conditions. Read all about it here biorxiv.org/content/10.1101/…
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This lets us count states and transitions between states under different perturbations
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We show that state probabilities are differentially...um...*modulated* by neuromodulators
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