@MarioniLab

The official Twitter account of the John Marioni Lab - not John himself. Single cells, statistics and computational biology.

Joined April 2019
  • Tweets39
  • Following40
  • Followers4.3K
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Are you missing cells and cell types in your single-cell multiome experiments @10xGenomics? Check out EmptyDropsMultiome @MarioniLab
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Join our faculty: ebi.ac.uk/research/groups - our 9-year tenure nurtures our group leaders to go on to do great things: @VirginieUhlmann @MoritzGerstung @OliverStegle @MarioniLab @teichlab @pedrobeltrao

Research groups

Our world-leading research groups focus on developing and applying computational and mathematical methods to a range of biological questions.

ebi.ac.uk
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Mark you calendars! Next Cambridge Computational Oncology Meeting is May 5 at the EBI in Hinxton. Speakers: Hillary Elrick @hbelrick , Alex Gutteridge @ruggedtextile and Peter Campbell
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Happy to present my recent work - a cluster-free method for DE testing, leveraging overlapping neighbourhoods in the graph representation of sc-data (aka miloDE): biorxiv.org/content/10.1101/… . A little thread below describes the motivation and suggestions on interpreting the results.

Sensitive cluster-free differential expression testing

Comparing molecular features, including the identification of genes with differential expression (DE) between conditions, is a powerful approach for characterising disease-specific phenotypes. When...

biorxiv.org
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MarioniLab retweeted
EMBL-EBI@emblebi8 Dec 2022
The developing human lung has been mapped in unprecedented detail, identifying 144 cell states in the early stages of life, and uncovering new links between developmental cells and lung cancer. ebi.ac.uk/about/news/researc…
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Excited to share @CarineStapel and my #singlecell #singleorganoid time course of #gastruloid development. We reveal substantial inter-organoid heterogeneity, and show why understanding it is critical in #organoid #perturbation experiments. A #tweetorial (1/18)
bioRxiv@biorxivpreprint28 Sep 2022
Inter-gastruloid heterogeneity revealed by single cell transcriptomics time course: implications for organoid based perturbation studies biorxiv.org/cgi/content/shor… #bioRxiv
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MarioniLab retweeted
EMBL-EBI@emblebi28 Jul 2022
AlphaFold DB will boldly go where no scientist has gone before. With over 200 million protein structure predictions added to the database, AlphaFold DB now gives users open access to a 3D protein universe. #AlphaFold @DeepMind ebi.ac.uk/about/news/technol…
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A magical week at the Marioni Lab retreat - a blessing of (purple) unicorns indeed and many (uni)corny jokes
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MarioniLab retweeted
EMBL-EBI@emblebi11 May 2022
John Marioni has been elected as a new Fellow to the @acmedsci 👏 in recognition of his remarkable contributions to biomedical science and the generation of new knowledge to improve the health of people everywhere. #AMSFellows2022
Academy of Medical Sciences@acmedsci11 May 2022
Congratulations to our 60 new Fellows announced today Find out more about these outstanding biomedical and health scientists and see the full list on our website: ow.ly/J2UV50J146j #AMSFellows2022
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We're hiring! Looking for an enthuastic postdoc to join the team and work with single-cell genomics data to construct and compare senescence trajectories for cells. Deadline 22nd Feb embl.org/jobs/position/EBI01…
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MarioniLab retweeted
EMBL-EBI@emblebi19 Jan 2022
The new @EMBL Programme has launched! We're proud to be a part of @EMBL and we're looking forward to contributing our #bioinformatics expertise to this exciting new scientific programme that ushers in a new era in the life sciences.
EMBL@embl19 Jan 2022
EMBL embarks on a new era of molecular biology. EMBL research will expand to study life in context – from molecules to ecosystems. Broad in scope, our next programme encompasses fundamental research, services & multidisciplinary collaboration. embl.org/news/lab-matters/a-…
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Congratulations to @Blavatnikawards 🇬🇧 Finalist 🏅 Finalist in Life Sciences Dr. John Marioni @MarioniLab @emblebi @CRUK_CI #Blavatnik2021 bit.nyas.org/3n0x0Yb #computationalbiology #RNAtranscription
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MarioniLab retweeted
EMBL-EBI@emblebi25 Oct 2021
What are the ripples of making data #openaccess? A recent independent report quantified these efforts to explore the role of #opendata in the life sciences today. #OAweek #opendata ebi.ac.uk/about/our-impact/i…
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Differential abundance testing on single-cell data using k-nearest neighbor graphs go.nature.com/2Y69iSH
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Still time to apply for our new postdoc position using computational approaches to study developmental trajectories across species. Deadline 19th September jobs.cam.ac.uk/job/31028/
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NEW POST: We (virtually) sat down with John Marioni, new collaborator on the Cancer Grand Challenges IMAXT programme @emblebi @CRUK_CI @sangerinstitute to find out more about his work and what excites him about the project. Read more - bit.ly/3svUnMP
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We're looking for a new postdoc in the Marioni group - a two year position to work on developmental trajectories across species using single-cell approaches and data integration methods jobs.cam.ac.uk/job/31028/
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Congratulations to Alsu @Alsu_Troost! Fantastic work.
amissarova@Alsu_Troost12 Aug 2021
Very excited to share geneBasis - an iterative approach to select an informative gene panel from your fave scRNA-seq data in an optimal manner. A thread below to briefly describe key points, and for those who do not mind TLDRs - biorxiv.org/content/10.1101/…. 1/n

geneBasis: an iterative approach for unsupervised selection of targeted gene panels from scRNA-seq

The problem of selecting targeted gene panels that capture maximum variability encoded in scRNA-sequencing data has become of great practical importance. scRNA-seq datasets are increasingly being...

biorxiv.org
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Fantastic to see @RArgelaguet and the team's work featured in this great @Nature article on the computational challenges of single cell multiomics! nature.com/articles/d41586-0…
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MarioniLab retweeted
EMBL-EBI@emblebi8 Jun 2021
Congratulations to our very own John Marioni and @Alexbateman1 and @embl’s Takashi Hiiragi for being elected as new @EMBO Members. 🎉 #EMBO #ScienceAward @MarioniLab ebi.ac.uk/about/news/announc…

EMBL scientists elected as EMBO Members

John Marioni, Alex Bateman, and Takashi Hiiragi have been elected to EMBO Membership

ebi.ac.uk
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