Yep, this is pretty much how I figured the 11 am caviar promo would turn out at @McDonalds

You may notice that these examples are 2D. We used 2D to rapidly iterate development of each of these models, but the grammar is tied to cell behaviors, not 2D or 3D. We were able to rapidly convert a 2D tumor-immune model to 3D, with ZERO changes to the model rules! 14/n

And in work led by Genevieve Stein-O'Brien (@GenesOfEve) and her team, she showed that the grammar isn't just limited to cancer or even cancer immunology. They built a model with @AllenCellInst brain atlas data, and modeled neurocortex development! 13/n

In their work, they were able to show how combining simple rules that "encode" single immunotherapies (again, no hand-written code!) could simulate and predict combination therapies, with big differences in ranked efficacy based on initial immune profiles! 12/n

They were able to use the grammar to entirely encode the complex model (again, no hand-written code!) including complex relationships between ECM density and cell migration that were revealed by experiments at Johns Hopkins. 9/n

They led innovative work to learn cell identities, positions, and even cell rules directly from spatial transcriptomics (single-cell gene sequencing that preserves cell position), and directly initialized models from individual patients! 8/n

Digging deeper Jeanette Johns and Daniel Bergman led work with Elana Fertig and a wide network of collaborators (including Laura Wood, Andy Ewald, Jude Phillips and others) to create a model of pancreatic cancer (PDAC) 7/n

We worked closely with Laura Heiser, Joe Gray, Lisa Coussens, and Young Hwan Chang at @OHSUKnight to write a model of ~12 simple rules to get immune response to a hypoxic tumor, including eventual immune exhaustion. Zero C++. 6/n

We showed a lot of examples using the new grammar, including re-writing prior modeling work with Daniele Gilkes (@GilkesLab @JohnsHopkins) where breast cancer cells respond to low O2 by increasing invasion. This model can be written in minutes without C++ in our new grammar. 5/n

We have been striving to find the commonalities in mathematical models of cancer and tissue ecosystems, simplify the process of creating these models, and unlock the methods to everyone. 2/n @galaxyproject @PhysiCell

If you're considering a @Logitech Combo Touch for your iPad Air, don't bother. $200+, and the C key fell off after a month of normal use. Technical support is an infuriating chat bot that won't connect to a human being (outside of sales) and won't help with an RMA.

CNN appears to have reverted back to April 2023. All teh stories link to April 18, 2023 content. I hear ya, @CNN. I'm avoiding 2025 too!