@MathijsSanders

Researcher, Erasmus MC Cancer Institute, Rotterdam, the Netherlands. Visiting post-doc Sanger Institute, Cambridge, UK.

scholar.google.com/citations?user=25WaFbIAAAAJ&hl=en#d=gs_hdr_drw
Joined August 2017
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  • Following475
  • Followers548
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Extremely grateful for receiving the EHA advanced research grant! Looking forward delving deeper into the disease mechanisms underlying AML. Congratulations to all EHA award winners! #EHA2024 @EHA_Hematology @ErasmusMC @erasmusmcblood
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Yang Ding, MD@YangDing19Oct 1
Very honored to be selected for a New Investigator Research Grant from the @LeukemiaRF. We @DingLabJHU are so grateful for this support in advancing discoveries for patients with hard-to-cure leukemias!
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Inigo Martincorena@imartincorenaSep 3
Big paper alert! This project has been years in the making. A comprehensive description of somatic mutation rates and signatures across 53 tissues or cell types using NanoSeq. A large collective effort led by Mimy Pham, Mike Stratton and Raheleh Rahbari. biorxiv.org/content/10.64898…

A comprehensive atlas of somatic mutation rates and mutational signatures in normal human cells

Over the course of a lifetime, somatic mutations accrue in normal human cells, causing variation in cell phenotype and engendering somatic evolution with outcomes ranging from the adaptive immune...

biorxiv.org
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Livius Penter@livius_tacitusAug 31
‼️ Job alert - #hiring ‼️ PhD position in leukemia TCR discovery #AML #immunotherapy #singlecell #bioinformatics A PhD position is available in the Penter lab (penterlab.org) at Charité – Universitätsmedizin Berlin in Germany. Please apply by October 12, 2026.
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Respiratory failure is a leading cause of death in AML. It begins when leukemia infiltrates the lung. Almost nothing was known about what happens locally. We looked. 🧵 @NatImmunol 🔗 nature.com/articles/s41590-0…

Inflammatory immune modulators of AML lung infiltration and respiratory failure

Nature Immunology - Paraskevopoulou et al. examine lung damage that occurs in patients diagnosed with acute myeloid leukemia (AML). In mouse models, AML infiltration leads to inflammatory...

nature.com
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Interested in the construction of high performance computing clusters? Do you have affinity with scientific computing and AI research? The Erasmus MC is looking for a Senior Engineer to help build its state-of-the-art HPC cluster. @ErasmusMC #HPC #IT werkenbijerasmusmc.nl/en/vac…
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Jamie Blundell@jrblundell3 Jul 2025
Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx. By brilliant @__AFonseca ✅Early cancer ✅Methylation drivers ✅Epimutation rates ✅CpG lineage tracing biorxiv.org/content/10.1101/…
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Read the commentary: Putting AML Differentiation States on the BoneMarrowMap, by Jonas Berger and Livius Penter, online now concurrent with #AACR25. doi.org/10.1158/2643-3230.BC…

Putting AML Differentiation States on the BoneMarrowMap

Summary:. This article presents a novel computational tool, “BoneMarrowMap,” that enables the mapping of leukemic single-cell RNA sequencing datasets to hematopoietic differentiation states. By...

aacrjournals.org
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Heng Li@lh3lh324 Mar 2025
longcallD is a new variant caller for genomic long reads. It jointly calls phased small and structural variants. Single binary, one command line for the whole process. Comparable accuracy to mainstream callers. Great work by Yan Gao. github.com/yangao07/longcall…

GitHub - yangao07/longcallD: LongcallD: joint calling and phasing of small, structural and mosaic...

LongcallD: joint calling and phasing of small, structural and mosaic variants from long reads - yangao07/longcallD

github.com
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Tim Coorens@TimCoorens20 Mar 2025
The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our Nature paper: nature.com/articles/s41586-0…

The somatic mutation landscape of normal gastric epithelium

Nature - Whole-gene sequencing of microdissected gastric glands from individuals with and without gastric cancer reveals distinct patterns of somatic mutations and provides insights into influences...

nature.com
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Applications for #TRTH2026 are now open! Are you an early-career researcher in translational hematology? The EHA-ASH TRTH program provides a unique opportunity to enhance your research skills with guidance from leading international experts. 🔹 Applications open today, March 15! 🔹 Deadline: June 26, 2025, at 11:59 PM ET Don’t miss this chance to advance your career in hematology research. Apply now! Learn more: eha.fyi/ashehaTRTH Apply now: eha.fyi/registerTRTH #HematologyResearch #CareerDevelopment #TRTH #TRTH2026
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Ruud Delwel@DelwelRuud2 Oct 2024
07 October 2024 at 16.00 CET Erasmus Hematology Virtual Lecture. We have: Kellie Machlus, Boston Children’s , with "Unraveling roles for megakaryocytes beyond platelet production through novel model systems" Spread the news! us06web.zoom.us/j/8272215941… @theclotthickens
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Today, we have Alexander Bick presenting! Don't miss it. 23 September at 16.00 CET Title: "Clonal hematopoiesis: causes, consequences and management" Link: us06web.zoom.us/j/8272215941…
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Excited to share our latest study in @JCO_ASCO on improving risk stratification for older patients (≥60 yrs) with Acute Myeloid Leukemia (AML)! We developed a novel prognostic model: AML60+. #Leukemia #AML link: ascopubs.org/doi/full/10.120… 🧵1/9

Risk Stratification in Older Intensively Treated Patients With AML

PURPOSEAML is a genetically heterogeneous disease, particularly in older patients. In patients older than 60 years, survival rates are variable after the most important curative approach, intensive...

ascopubs.org
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Our single-cell, pan-cancer analysis of open chromatin in human cancers, done in collaboration with TCGA and the Chang and Corces labs (among others including Illumina), is out in Science today. Congrats to Laksshman Sundaram and all authors! science.org/doi/10.1126/scie…

Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers

To identify cancer-associated gene regulatory changes, we generated single-cell chromatin accessibility landscapes across eight tumor types as part of The Cancer Genome Atlas. Tumor chromatin...

science.org
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New review by @sjfhermans, @niek_maas, @JurjenVersluis and others, detailing how real-world data can be of added value if collected and used appropriately!
Niek van der Maas@niek_maas30 Aug 2024
New paper out in @JAMAOnc! 🚨 Real-world data (RWD) external control arms are gaining traction in prospective studies, but we need to balance their advantages with meeting evidentiary standards Our review highlights significant differences between RWD and trial data🧵(1/7)
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Peter Ly@PeterLyLab23 Aug 2024
🚨 Excited to share our latest paper in @CellCellPress identifying how under-replicated chromosomes in micronuclei become shattered by the Fanconi anemia pathway during mitosis. This work was led by @UTSWGradSchool student @JustinEngel17. 🧵 (1/13): cell.com/cell/fulltext/S0092…

The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance

A genetic screen uncovers the Fanconi anemia pathway as a driver of chromothripsis by shattering under-replicated micronuclear chromosomes during mitosis. This process involves chromosome-scale...

cell.com
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Join us! The Machado Lab at @Cambridge_Uni is looking for an enthusiastic RA to be a core member of the team and lead the lab's data generation efforts, seeking to understand how tumour and immune cells co-evolve and contribute to cancer progression. jobs.cam.ac.uk/job/47922/
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Petri Pölönen@PolonenPetri15 Aug 2024
Interested in non-coding alterations, large-scale genomics, leukemia? Collaboration between @CMullighan and Teachey labs. Genomic analysis of >1300 WGS/WTS/WES samples from T-lineage acute lymphoblastic leukemia, out now in @Nature nature.com/articles/s41586-0… Highlights (7):

The genomic basis of childhood T-lineage acute lymphoblastic leukaemia

Nature - Comprehensive genomic and transcriptomics analyses of more than 1,300 cases of childhood T-lineage acute lymphoblastic leukaemia identify 15 distinct subtypes that are associated with...

nature.com
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Peter Campbell leaves the Sanger Institute at the end of the year to become Quotient's CSO. A mentor and one of my favourite scientists. His foundational, profound and creative contributions to cancer genomics and somatic evolution have truly shaped those fields. [1/7]
Quotient Therapeutics@QuotientTx7 Aug 2024
Academic co-founder, Peter Campbell, Ph.D., is joining the Quotient team as CSO. We look forward to advancing the first ever #SomaticGenomics platform under his leadership. Read more: bit.ly/3YBCkqS
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Ruud Delwel@DelwelRuud5 Aug 2024
Proud of the review by Roger Mulet-Lazaro on "Oncogenic Enhancers in Leukemia" in Blood Cancer Discovery in August issue. Great stuff for teaching! aacrjournals.org/bloodcancer… @RogerMulet @BCD_AACR
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