@MatthewCulyba

Infectious diseases physician-scientist

 Pittsburgh, PA
Joined August 2020
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Check out our @TheCulybaLab publication on how MRSA evades antibiotics during persistent bacteremia: Convergent Evolution of Antibiotic Tolerance in Patients with Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia | Infection and Immunity journals.asm.org/doi/10.1128…

Convergent Evolution of Antibiotic Tolerance in Patients with Persistent Methicillin-Resistant...

Severe infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are often complicated by persistent bacteremia (PB) despite active antibiotic therapy. Antibiotic resistance rarely...

journals.asm.org
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We found many mutations that wrecked citrate synthase (citZ) of the tricarboxylic acid cycle and led to antibiotic tolerance. Also, several mutations in the stringent response regulator, rel. Lots of within-host evolution going on in these persistent bacteremia cases! Stop #MRSA!
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Thank you to @ryankshields for the samples and @DariaVanTyne for her bioinformatics expertise. Great to be @IDPittStop, @Pitt_CEBaM. #MRSA #AntibioticResistance
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