Neuroimmunologist Principal Investigator, McAlpine Lab Researcher & Expert in Neuropsychiatric Long COVID Yale University School of Medicine
Connecticut
Joined June 2009
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Lindsay McAlpine MD retweeted
Calling folks in the Northeast! We’re recruiting individuals with Long COVID and brain fog or cognitive difficulties for a Yale research study involving an MRI with gadolinium contrast. See the flyer for details, and please share! #longcovid
Bringing awareness to ME/Chronic Fatigue Syndrome! I was so happy to talk to @NBCConnecticut this month about this condition, Long COVID, and the research we are doing #mecfs @NeurologyYale @YaleMed
nbcconnecticut.com/video/new…
Calling folks in the Northeast! We’re recruiting individuals with Long COVID and brain fog or cognitive difficulties for a Yale research study involving an MRI with gadolinium contrast. See the flyer for details, and please share! #longcovid
Lindsay McAlpine MD retweeted
Thanks to @BrainInflCollab for discussing my papers on #POTS, #MECFS and #LongCOVID as neuroimmune disorders and a possible CNS localization of POTS/dysautonomia to the dorsolateral medulla! 🧠
Read more about these emerging topics here:
tandfonline.com/doi/full/10.…
mdpi.com/2227-9059/13/1/166
Key brainstem regions help control heart rate, blood pressure, breathing, and the body’s inflammatory “brake” through the vagus nerve.
In this article, we examine neuroimaging and post-mortem findings in COVID-19, a recent neuroimmune hypothesis for POTS, the medulla’s role as an inflammatory thermostat, and how connective tissue laxity or mast cell activation may amplify vulnerability in a subset of patients.
Read more here: buff.ly/Lx71wkY
Lindsay McAlpine MD retweeted
#COVID19:
🟢 Prevent yourself from getting sick
🟢 Stay protected, especially if you are at higher risk of severe illness
🟢 Prevent spreading it to others if you do get sick
ALT Tips to prevent COVID-19: wash hands frequently, wear masks in crowds, improve ventilation, and get vaccinated.
ALT Guidelines to prevent spreading COVID-19 when sick include staying home, wearing a mask, covering coughs, frequent handwashing, and improving ventilation.
ALT Advice for those at higher risk of severe COVID-19: get vaccinated, wash hands frequently, wear masks in crowds, and improve ventilation indoors.
Lindsay McAlpine MD retweeted
So incredibly excited BioVie announced the positive results from our Phase 2 ADDRESS-LC trial of bezisterim in Long COVID and proud to have contributed! Thank you to our wonderful participants @BioVie_Pharma #LongCOVID
investors.bioviepharma.com/n…
Lindsay McAlpine MD retweeted
My patients often report improvement with GLP-1 RAs. Today one patient with #dysautonomia/#MCAS told me she is back to running after starting GLP-1 RA. 🏃♀️
📢 Our paper on post-COVID vaccination dysautonomia improving after GLP-1 RA was just published!
tandfonline.com/doi/full/10.…
Lindsay McAlpine MD retweeted
It has been such a pleasure to be a part of this! Looking forward to further data and next steps with the Phase 3 trial.
Today, we announced positive results from our Phase 2 signal finding ADDRESS-LC trial evalulating bezisterim for the treatment of neurological symptoms associated with Long COVID. Read: investors.bioviepharma.com/n…
$BIVI
So incredibly excited BioVie announced the positive results from our Phase 2 ADDRESS-LC trial of bezisterim in Long COVID and proud to have contributed! Thank you to our wonderful participants @BioVie_Pharma #LongCOVID
investors.bioviepharma.com/n…
Lindsay McAlpine MD retweeted
Today, we announced positive results from our Phase 2 signal finding ADDRESS-LC trial evalulating bezisterim for the treatment of neurological symptoms associated with Long COVID. Read: investors.bioviepharma.com/n…
$BIVI
Long COVID patients still lack access to specialized rehab. We urgently need disease-modifying therapies and individualized cognitive rehabilitation should become a standard part of care—just as it is for TBI and MS. #LongCOVID time.com/article/2026/07/06/…
Lindsay McAlpine MD retweeted
'STORM' is a short documentary about Scott Hugo. A story of Long COVID's impact on his life and family - a reminder of what is at stake in research on Long COVID.
His resilience humbles me.
Please watch and share 🙏🏼
youtu.be/rLtXh28Eejw
Pleased to share our latest COVID Mind Study @ Yale publication: "Vascular inflammation in neuropsychiatric long COVID" Elevated markers of endothelial adhesion in LC correlates with lower verbal fluency and learning.
doi.org/10.1016/j.bbih.2026.…
Lindsay McAlpine MD retweeted
🫀🧠 My new paper in a cardiology journal: appreciate that my cardiology colleagues like my ideas and don't reject my papers because my ideas are "too new" - a comment I got from an editor of another journal on a different paper that was rejected. 🤪
heartrhythmopen.com/article/…
Lindsay McAlpine MD retweeted
🧠🔬 Clinical Trial in Focus
The phase 2 ADDRESS-LC study (NCT06847191) is evaluating @BioVie_Pharma's bezisterim for neurological symptoms linked to Long COVID.
Includes expert insight from @McAlpineLabYale, of @YaleMed.
🔗 Read more: hubs.li/Q04f27wF0
HIRING! We are hiring postgraduate research associates starting June 2026. Please send talented folks interested in neuropsych Long COVID & PAIS our way!
postdocs.yale.edu/posts/2026…
Join our study site for the ADDRESS-LC Clinical Trial investigating Bezisterim in Long COVID!
Email: [email protected]
addresslongcovid.com/
Long COVID & Bezisterim Clinical Trial is now open at Yale!
Email: [email protected]
Website: addresslongcovid.com/
Lindsay McAlpine MD retweeted
Excited to share my friend and fellow Brown alum’s Neuro + Vertigo Physical Therapy account!
Education | Support | Treatment
instagram.com/balancingactre…