Mick Lee (@Meekelee) header
Mick Lee (@Meekelee) profile picture

Mick Lee

@Meekelee

Post Doctoral Fellow @ NUS CVRI Cardiovascular // Scientific illustrator & Photographer https://teapaw.org/t.co/uoJcWUM3xp // https://teapaw.org/t.co/HdHmnLWwJz //Stem Cells

 Singapore
cjmlee.github.io
Joined April 2011
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Photo by Mick Lee (@Meekelee)Photo by Mick Lee (@Meekelee)Photo by Mick Lee (@Meekelee)Photo by Mick Lee (@Meekelee)Photo by Mick Lee (@Meekelee)Photo by Mick Lee (@Meekelee)Photo by Mick Lee (@Meekelee)Photo by Mick Lee (@Meekelee)Photo by Mick Lee (@Meekelee)Photo by Mick Lee (@Meekelee)
Excited to share our new review in @CellCellPress. We propose fibrosis is a reversible state encoded in chromatin circuits shaped by immune-stromal crosstalk, and that rewiring this logic may offer durable therapeutic paths. @GladstoneInst authors.elsevier.com/sd/arti…
Image from Michael Alexanian (@m_alexanian)
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Excited to share our RegVelo paper in Cell cell.com/cell/fulltext/S0092… We unify RNA velocity + GRNs into one model → better OOD prediction of perturbations (e.g. gene KOs), with examples incl. neural crest KO predictions 🔬 Big thanks to W Wang, Z Hu & T Sauka-Spengler 🙏
Image from Fabian Theis (@fabian_theis)
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Mick Lee retweeted
Rahul Satija (@satijalab) profile picture
Rahul Satija@satijalabFeb 17
Excited to share VIPerturb-seq! New tech from my lab which aims to improve the cost, data quality, and efficiency of single-cell CRISPR screens so that they are accessible to any lab - even at genome-wide scale Preprint and 🧵 (1/): biorxiv.org/content/10.64898…
Genome-wide single-cell perturbation screens with VIPerturb-seq

Genome-wide single-cell perturbation screens with VIPerturb-seq

CRISPR-based screening combined with single-cell sequencing (i.e. Perturb-seq) enables systematic mapping of genetic perturbations to molecular phenotypes. While Perturb-seq is well-suited to profile...

biorxiv.org
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eQTLGen is for years the largest eQTL resource out there. They now released the second phase of this initiative from 43,301 samples, revealing cis-eQTLs for 94% and trans-eQTLs for 56% of human genes. Amazing resource for following-up on GWAS signals👇
Image from Marios Georgakis (@MariosGeorgakis)
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HumanBase: an interactive AI platform for human biology nature.com/articles/s41592-0…
Image from Nature Methods (@naturemethods)
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In @ScienceMagazine we used single cell multiomics, human PET imaging, and in vivo lineage tracing to identify FAP as a marker of modulated vascular cells in coronary artery disease. We used anti FAP BiTE therapy to reduce plaque burden in vivo. science.org/doi/10.1126/scie…
Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy

Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy

Vascular smooth muscle cell (VSMC) diversification drives atherosclerotic coronary artery disease (CAD), but the mechanisms governing these cell state transitions remain unclear. We applied multiomic...

science.org
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New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.
Image from Thomas Norman (@thenormanlab)
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We discover RUNX1 as a nodal regulator of human cardiac recovery and uncover a druggable epigenetic mechanism in macrophages that orchestrates functional, structural, and molecular features of organ recovery @LavineLab @m_alexanian @Amgen @ImmunoFibHF biorxiv.org/content/10.1101/…
Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

Despite advances in disease treatment, our understanding of how damaged organs recover and the mechanisms governing this process remain poorly defined. Here, we mapped the transcriptional and...

biorxiv.org
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@CircRes Interorgan Crosstalk in #HF & #Cardiometabolic Diseases Compendium CV, #Kidney, #Liver, & Metabolic Interactions in #HF: Breaking Down Silos ahajrnls.org/3ZtHfJQ by @rsyf2 @josephahill @FaiezZANNAD @ShahzebKhanMD @JenHoCardiology @leahkosyakovsky et al
Image from Circulation Research (@CircRes)
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Special thanks to Issei Komuro and the amazing organizing committee for a fantastic meeting #ISHR2025 Nara. The bar has been set very high for future ISHR meetings. Congratulations to postdoctoral fellow Marion Delaunay for giving an invited lecture and winning a poster award!
Image from McKinsey Lab (@McKinseyLab)
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Roger Foo (@rsyf2) profile picture
Roger Foo@rsyf224 Apr 2025
A lab becomes super exciting when it gets made up of super bright young people (not referring to me), so somewhat shamelessly doing a shout out here for their incredible effort. Started by crowdsourcing, an iPS cell bank here now in Asia. "We are open for business" @NUSMedicine
Image from Roger Foo (@rsyf2)
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Our first foray into using AI to tackle human cardiac fibrosis. ahajournals.org/doi/full/10.…. Amazing collaboration with @gwaybio and waysciencelab.com. Spearheaded by @JoshTravers89 and @jenna_tomkinson. Tip of the iceberg. Stay tuned!
Image from McKinsey Lab (@McKinseyLab)
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We use CITE-seq, Xenium, human PET imaging, and in vivo lineage tracing to identify FAP as a marker of modulated SMCs in human coronary artery disease and show that treatment with an anti FAP bi-specific T cell engager reduces plaque burden in vivo biorxiv.org/content/10.1101/…
Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy

Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy

Vascular smooth muscle cell (VSMC) and immune cell diversification play a central role in driving atherosclerotic coronary artery disease (CAD)[1][1]–[3][2]. However, the molecular mechanisms...

biorxiv.org
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Excited to share our latest article. 7 years ago my then 9 year old son was diagnosed with K210del DCM. With the help of my colleagues @Joseph_C_Wu, @sadayappanlab and Enzo Porrello we identified an FDA approved drug that corrects the mutation. JCI - An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models jci.org/articles/view/174081
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Thank you @ajpheartcirc for publishing our recent work on BRD4 in cardiac macrophages. Huge effect on MHC-II levels. doi.org/10.1152/ajpheart.004…. Great team effort and collaboration with many, including @VagnozziRJ and @m_alexanian.
Image from McKinsey Lab (@McKinseyLab)
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Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵
Image from Jonathan Pritchard (@jkpritch)
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Introducing scE2G: a new model to link enhancers to target genes using single-cell data. Excited that scE2G will enable building enhancer maps in hundreds of cell types in the human body! Wonderful collaboration with @robin_andersson @613weilin @mayayayas and others 👇
Wei-Lin Qiu (@613weilin) profile pictureWei-Lin Qiu@613weilin25 Nov 2024
Excited to share our latest preprint on scE2G – a new model to link enhancers to target genes using single-cell data – with state-of-the-art performance across multiple perturbation benchmarks. biorxiv.org/cgi/content/shor… Read more below! 1/12
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We use Multiome and HiC to build a comprehensive single cell variant to enhancer to gene map for coronary artery disease. Join effort with @PaulChungrohLee and IttaiEres in Nate Stitziel Lab and in collaboration with @Amgen @WUSTLmed medrxiv.org/content/10.1101/…
Single cell variant to enhancer to gene map for coronary artery disease

Single cell variant to enhancer to gene map for coronary artery disease

Although genome wide association studies (GWAS) in large populations have identified hundreds of variants associated with common diseases such as coronary artery disease (CAD), most disease-associa...

medrxiv.org
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Check out the work on targeting IL-1 in heart failure from the legend @junedh_amrute as well as a sister paper by @m_alexanian from previous post!
Junedh M. Amrute (@junedh_amrute) profile pictureJunedh M. Amrute@junedh_amrute23 Oct 2024
In ⁦@Nature⁩ we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with ⁦@LavineLab⁩ ⁦@washumedicine⁩, ⁦⁦@Amgen⁩ , and ⁦@ImmunoFibHF⁩ nature.com/articles/s41586-0…
Targeting immune–fibroblast cell communication in heart failure

Targeting immune–fibroblast cell communication in heart failure

Nature - A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling...

nature.com
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🎉Excited to finally share that our new work (previously @biorxivpreprint) is now online at @Nature! A fantastic team effort with amazing collaborators. You can read the paper by using the following link: rdcu.be/dXQs7 A thread 🧵/1 nature.com/articles/s41586-0…
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