Mert Tokcan (@MertTokcan) profile picture

Mert Tokcan

@MertTokcan

Resident in Cardiology and Clinician Scientist @Saar_Uni

 Homburg, Deutschland
Joined August 2023
  • Tweets6
  • Following107
  • Followers19
Mert Tokcan retweeted
JAHA (@JAHA_AHA) profile picture
JAHA@JAHA_AHA30 Jul 2025
Renal denervation reduces indoxyl sulfate and LVH in CKD rats. A potential therapeutic target in uremic cardiomyopathy? #AHAJournals ahajrnls.org/4ovwgL5
Image from JAHA (@JAHA_AHA)
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💥Assessing phototoxic drug properties of hydrochlorothiazide using human skin biopsies. pubmed.ncbi.nlm.nih.gov/4032… 👉 and reduce animal testings, #3R, @MertTokcan, @FelixMahfoud, @lea_wagmann, @Saar_Uni
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Macrophages and cardiomyocyte sodium channels in mice. link.springer.com/article/10…
Macrophages enhance the effects of flecainide on cardiomyocytes. For electrophysiological analysis, patch-clamp of CMs in coculture conditions with macrophages were compared with a single suspension of CMs. (a) Co-culture experiments show a more positive RMP and a decrease in APA with an increase in Vmax and APD50. Application of flecainide does not significantly change the absolute values in CM alone. However, we can see the expected change as a trend towards a lower Vmax after the application of flecainide. In contrast, under co-culture conditions with macrophages significant changes can be observed upon flecainide treatment. Numbers of individual experiments are indicated in the figure.

ALT Macrophages enhance the effects of flecainide on cardiomyocytes. For electrophysiological analysis, patch-clamp of CMs in coculture conditions with macrophages were compared with a single suspension of CMs. (a) Co-culture experiments show a more positive RMP and a decrease in APA with an increase in Vmax and APD50. Application of flecainide does not significantly change the absolute values in CM alone. However, we can see the expected change as a trend towards a lower Vmax after the application of flecainide. In contrast, under co-culture conditions with macrophages significant changes can be observed upon flecainide treatment. Numbers of individual experiments are indicated in the figure.

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Mert Tokcan retweeted
Circulation (@CircAHA) profile picture
Circulation@CircAHA2 Oct 2024
Meta-analysis: renal denervation (RDN) significantly lowers 24-hour and office BP by 4.4 mmHg and 6.6 mmHg, respectively, compared to sham procedures. Safety outcomes similar between RDN and sham. @DLBhattMD ahajournals.org/doi/abs/10.1…
Image from Circulation (@CircAHA)
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Human coronary arteries contain a dense network of sympathetic nerve fibers, with notable differences in their distribution and density. Gaining a deeper understanding of these patterns improves our knowledge of #cardiovascularpathophysiology and may contribute to the development of catheter-based techniques for modulating cardiac autonomic function. @MertTokcan, @FelixMahfoud #eapci shorturl.at/tL1g7 Editorial by @MichaelJoner3 and A. Beele eurointervention.pcronline.c…
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Amazing scientific retreat at our joint #AG41 and AG4 #SpringSchool ! Thanks to the organizing committee and to all scientific contributors for their inspiring talks and posters. @DGK_org @YoungDgk @GoettschLab @PhilipWenzel_76 @HilgendorfIngo @DDuerschmied @SteffensLab
Image from AG4 - Vaskuläre Biologie (@AG4_DGK)
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