@MoldovanLab

Genome stability, DNA repair, replication stress, functional genomics, basic cancer biology

 Hershey, PA
sites.psu.edu/moldovan/2016/07/26/hello-world/
Joined December 2020
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Sharing our latest review on single stranded DNA gaps and their impact on cancer chemotherapy outcomes portlandpress.com/biochemj/a…

Understanding single stranded DNA gaps: from formation to fate

Abstract. Single-stranded DNA gaps (ssDNA gaps) have emerged as a potential indicator of therapeutic response in cancer. Accumulation of ssDNA gaps is associated with increased sensitivity of cancer...

portlandpress.com
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Sharing our new paper on the nuclease EXO1. We employed CRISPR genome-wide screening and identified an EXO1 pathway for R-loop suppression doi.org/10.1093/nar/gkag226

Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage

Abstract. DNA repair is critical for cellular homeostasis under both normal conditions as well as in response to genotoxic agents such as chemotherapeutics

academic.oup.com
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Sharing our work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. nature.com/articles/s41467-0…

The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells

Nature Communications - DNA repair genes are generally considered tumor suppressors, as they maintain genomic stability. Here, the authors show that the exonuclease EXO1 is overexpressed in a...

nature.com
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Thrilled to announce that Alexandra Nusawardhana, graduate student in the lab, was awarded an F31 National Research Service Award fellowship by @theNCI to investigate the role of EXO1 in genomic stability. Congratulations Lexi!
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So happy and proud to hood Drs. Lindsey Pale, Jude Khatib and Josh Straka at the 2025 Penn State College of Medicine Commencement ceremony. Congratulations and all the best in your careers!
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