@MoldoveanuLab

Cell Death and Cancer Biology at UAMS Winthrop P. Rockefeller Cancer Institute

 Little Rock, AR
medicine.uams.edu/biochemistry/faculty/primary/moldoveanu/
Joined September 2019
  • Tweets153
  • Following285
  • Followers349
17Media
Excited to share my paper, now online in Cell! 🎉 Using integrated proteomics, we uncovered proteostasis remodeling during T cell exhaustion. Huge thanks to the @ideaproteomics and our collaborators! @BrianKoss @uamscancer @uamshealth @UAMS_MD_PhD cell.com/cell/fulltext/S0092…
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Structural basis of BAK sequestration by MCL-1 in apoptosis dlvr.it/TKFJFw
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Apoptosis inhibition: MCL-1 vs BAK Our new study published in Molecular Cell featuring classic BCL-2 family proteins inhibition of apoptosis by oncogene MCL-1 who blocks mitochondrial outer membrane permeabilization by the pore-forming protein BAK: authors.elsevier.com/a/1ktSg…
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The paper has a bit of something for everyone who enjoys structure, function, & cancer targeting. For instance, we presented a cryo-EM structure of the 40 kDa MCL-1:BAK complex revealing features we think apply to the relevant BCL-2 family interactome.
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We also profiled some of the drugs that inhibit MCL-1, but failed thus far in clinical trials due to (cardio)toxicity, and we think there is room for improving them. We thank many wonderful colleagues who collaborated to make this possible. Happy Easter for those who celebrate!
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We are hiring! Please see these two opportunities to become part of our National Resource Team. Principal Staff Scientist uasys.wd5.myworkdayjobs.com/… Associate Staff Scientist uasys.wd5.myworkdayjobs.com/…
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Are all folded BCL-2 family proteins pore-forming? It surely seems that if one tries hard enough they could be made pore-formers, but now clearly 4 of them stand out: BAK, BAX, BOK & tBID. I reflect on this problem in #BioEssays onlinelibrary.wiley.com/doi/…
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BTW, our new lab @UAMS_Biochem @uamscancer is now seeking scientists interested in addressing open questions in cell death research and cancer biology with structural (cryo-EM🤍) and chemical biology tools! DM me if curious. We make science fun!
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MoldoveanuLab retweeted
HalicLab@LabHalic23 Nov 2022
Our latest work on chromatin and ribosomes was published today. Great collaboration with @kriwacki lab. Congratulations to everyone involved. authors.elsevier.com/sd/arti…
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📰Our analysis of apoptosis regulation in vascular endothelial and smooth muscle cells is now published! We find that cells comprising the vasculature are primed to die, rendering them hypersensitive to anti-cancer agents to drive cardiovascular tox! 🧵1/n science.org/doi/10.1126/scia…

Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to...

Apoptotic sensitivity of vascular cells is associated with clinical cancer therapy–induced toxicities.

science.org
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MoldoveanuLab retweeted
Junmin Peng@JunminPengLab14 Oct 2022
RNA splicing defects contribute to Alzheimer’s disease - St. Jude. Grateful for the contribution of all group members and collaborators, Drs. Yu, Beach, Bennett, Wu, Chen, ⁦Zakharenko, ⁦@mikedyerlab⁩, ⁦@RSmeyne⁩, ⁦@MoldoveanuLab⁩ stjude.org/media-resources/n…

Model demonstrates how RNA splicing defects contribute to Alzheimer’s disease

St. Jude scientists studied the role of RNA splicing defects in Alzheimer’s disease, revealing degeneration and toxicity caused by neuron hyperexcitability.

stjude.org
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We're excited to share our report on apoptotic vulnerabilities in AL amyloidosis. We analyzed over 50 primary specimens from AL patients at @BU_Amyloidosis and find that clonal plasma cells are frequently dependent on BCL-2 or MCL-1 for survival. (1/n) nature.com/articles/s41467-0…
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Replying to @MoldoveanuLab @iScience_CP @GeetikaGitika2
We are honored to have contributed to this exciting discovery of the novel BAK activator SJ572946. We believe direct modulation of #apoptosis can help treat or prevent a wide range of diseases, including cancers, and this discovery helps bring us closer to that goal.
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Replying to @MoldoveanuLab @CristinaGuibao @RichardLeeLab @zintisinde
Congratulations @MoldoveanuLab and collaborators on this important advance. We regret that Geetika wasn't able to celebrate with you but know that this paper can serve as part of her scientific legacy.
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MoldoveanuLab retweeted
Richard@Richard_E_Lee23 Sep 2022
Replying to @MoldoveanuLab @iScience_CP @GeetikaGitika2
Geetika was such a bright spark. The dedication is a great way to remember her.
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We dedicate @iScience_CP paper on #apoptosis initiation with BAK activators to Dr. Geetika Singh @GeetikaGitika2, who recently lost her life to cancer. We are humbled by this tragedy and grateful for life and important contributions at many levels. doi:10.1016/j.isci.2022.105064
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more replies
The most useful use, however, has been to probe the mechanism of BAK activation and we show that our lead compound cooperates with BID to activate a BAK mutant severely impaired in apoptosis initiation
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Special thanks to our outstanding lab members and collaborators at St. Jude and Harvard including @CristinaGuibao, @RichardLeeLab, Kris Sarosiek and his crew @CellDeathLab including @zintisinde, and all twitter-less others. RIP Geetika
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