Monadic DNA retweeted
First siting of @StoffelMPC in the wild on the 4th week anniversary of our launch
"Where are the use cases for MPC?" They said
Well, here's one that isn't bullshit.
Great work @vishakh @MonadicDNA
Replying to @zaimiri
this is why we need @Amino_Chain + @MonadicDNA
i like to call it "DeSci" or Decentralized Science
Monadic DNA retweeted
Standard short read genome sequencing is pretty much a commodity now. The value is actually in the interpretation/reports.
Monadic DNA retweeted
First talk I'll ever give about Dark Bio... no pressure... none whatsoever... 🙈
Monadic DNA retweeted
Following on from Kitchen table genomes/liquid biopsy. There are two forces at work, a centralization one and a decentralization one. Large companies are trying to trap everything in central data centers with proprietary data streams, giving them a moat and control, others are pushing to run AI and other things locally empowering individual users. Same is happening to bio/medical data including sequencing.
Microsoft just solved the context window problem.
Right now, every AI suffers from a fatal flaw: the "context window problem."
When an AI reasons through a complex problem, it generates a massive chain-of-thought. But there is a catch. It has to keep every single token of that thought in its active memory.
The technical term is the "KV Cache."
The longer the AI thinks, the heavier it gets. It slows down. It gets expensive. Eventually, it runs out of space.
We thought the only fix was renting bigger, more expensive cloud GPUs to hold all that context.
Microsoft just proved us wrong. They published a paper called "MEMENTO."
Instead of giving the AI a bigger memory, they taught it how to forget.
Here is how it works:
Instead of generating one endless stream of consciousness, a Memento-trained model breaks its reasoning into small blocks.
After it finishes a block, it writes a dense, highly compressed summary of its own logic—a "memento."
Then, it does something unprecedented.
It physically deletes the entire previous reasoning block from its memory cache.
It only carries the memento forward. The model reasons, extracts the core logic, and instantly drops the dead weight.
The results rewrite the economics of running AI.
• Context length compressed by 6x.
• Active memory usage (KV cache) reduced by 2.5x.
• Zero loss in math, science, or coding accuracy.
And here is the real implication.
Big tech has been charging you by the token for massive context windows you don't actually need.
With this architecture, small businesses and solo operators can run complex, multi-step autonomous agents entirely locally.
You don't need an enterprise cloud setup. A standard machine running an open-source model can now reason indefinitely without overflowing its memory. No API fees. Complete privacy.
We spent the last two years trying to give AI an infinite memory.
It turns out, the secret to smarter AI isn't remembering everything.
It's knowing exactly what to forget.
The Vercel breach put the problem in plain sight.
Too many systems still keep sensitive logic and data stored in one place.
nilDB exists to break that pattern.
- Sensitive data is split before it is stored
- It is distributed across multiple nilDB nodes
- No single node holds the complete secret
- No single breach reveals the whole dataset
That’s why Nillion matters: it gives builders a privacy layer for sensitive data.
Monadic DNA retweeted
one of the reasons i became a medical geneticist: the genome is the only medical test where we measure once, but our interpretation evolves indefinitely.
as our models and variant knowledge mature, the same data yields new truths, and eventually, actionabilities.
the genome (and its derivative products) are the ultimate substrates for AI in medicine.
Patrick Collison@patrickcApr 17🇺🇸
United StatesConnected via United States App StoreAccount-level information, not a live location or per-post device.
I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools.
With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments.
Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know.
I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars.
(One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.)
There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!
Monadic DNA retweeted
@nillion is building what they call a blind computer.
plain english: your data never leaves your device unencrypted. When it gets processed by AI the computation happens on the encrypted version. The nodes running the computation cannot see what they are working with.
Not "we promise not to look." structurally impossible to look. the mathematics prevent it.
They launched nilGPT, an AI chatbot where your conversation history is stored encrypted across decentralised nodes. The operator cannot read your chats. By the end of Q2 2025 it had processed 1.3 million inference calls.
xitter.cf/nillionnetwork/status/…
@MonadicDNA is doing the same for genetic data. sequencing and analysing dna under full encryption. no one in the network sees your genetic information, including the people running the service.
Monadic DNA retweeted
If you're a trader and have taken a genetic test before, this is for you.
Participate in @MonadicDNA's campaign to find out if your risk appetite is genetic.
More details 👇
Your trading risk appetite might be genetic.
Degens and non-degens take risk very differently.
@MonadicDNA is running a community study using Nillion to process private genetic data to find out answers to all of these questions and more!
Monadic DNA retweeted
Are your degen traits all driven by your DNA?
This is the study launched by @MonadicDNA on @nillion.
Upload your DNA data and benefit from private AI analysis on @nillion to determine how much of a degenerate you are by nature 👀
Your trading risk appetite might be genetic.
Degens and non-degens take risk very differently.
@MonadicDNA is running a community study using Nillion to process private genetic data to find out answers to all of these questions and more!
Monadic DNA retweeted
Turns out I'm a little more degen than I realized
Thanks to @MonadicDNA and @nillion for helping me realize the truth that lies within my genes
Your trading risk appetite might be genetic.
Degens and non-degens take risk very differently.
@MonadicDNA is running a community study using Nillion to process private genetic data to find out answers to all of these questions and more!
Monadic DNA retweeted
Your trading risk appetite might be genetic.
Degens and non-degens take risk very differently.
@MonadicDNA is running a community study using Nillion to process private genetic data to find out answers to all of these questions and more!
Monadic DNA retweeted
Replying to @nillion
Can't imagine genomics running on anything that isn't inherently private
Monadic DNA retweeted
Private genomics, running on privacy-preserving AI.
Gnillion ⚔️
Monadic DNA Explorer now uses @nillion's nilAI mainnet instance.
⚡️LLM analyses run much faster now.
🤖 gpt-oss-20b provides more intelligent commentary on genetic traits
Monadic DNA retweeted
Interested in genomics? This tool is for you.
It lets you explore genetic studies, and you can filter the ones that are relevant to you by uploading the results of popular genomic tests like 23andMe, Ancestry, etc.
@nillion AI can then break it down for you.
Privately🔒.
Monadic DNA Explorer now uses @nillion's nilAI mainnet instance.
⚡️LLM analyses run much faster now.
🤖 gpt-oss-20b provides more intelligent commentary on genetic traits
Monadic DNA retweeted
analyzing genetic traits with AI on @nillion
beyond exciting to see the new real use cases emerging on privacy infra that go beyond purely financial primitives.
Monadic DNA Explorer now uses @nillion's nilAI mainnet instance.
⚡️LLM analyses run much faster now.
🤖 gpt-oss-20b provides more intelligent commentary on genetic traits
Monadic DNA retweeted
just returned from @Nillioneco 's ecosystem call to witness @MonadicDNA's demoing their local genome inference project that can run entirely inside your browser or utilize nilAi if needed. Mind still blown, this redefines private genetic analysis, blind compute ftw.
Our next ecosystem demo is with @MonadicDNA and it’s EPIC.
Join us for an exclusive look at what the team’s been working on, and the incredible progress they’ve made.
Don't miss it 👇
xitter.cf/i/broadcasts/1mnxeNnYE…
Monadic DNA retweeted
we are live with @MonadicDNA
xitter.cf/i/broadcasts/1mnxeNnYE…


























