@MossbauerLab
 Pittsburgh, PA
chem.cmu.edu/groups/guo/
Joined November 2017
  • Tweets223
  • Following256
  • Followers332
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Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…

Regio- and Stereoselective Halogenation by an Iron(II)- and 2‑Oxoglutarate-Dependent Halogenase in...

Abstract. Iron­(II)- and 2-oxoglutarate-dependent (Fe/2OG) enzymes have garnered strong research interest in past decades due to their ability to catalyze

pubs.acs.org
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Alex Guo retweeted
PSU Bioinorganic@psunerdcircus17 Feb 2024
The Penn State Bioinorganic Workshop will be offered from May 29 - June 4 - please see updates at sites.psu.edu/bioinorganic/2… with @jmarbol21 @BookerMan_PSU @CotruvoLab @StollPatrol @Prof_SJE @MossbauerLab @ShafaatLab @TamraBlue3 @jwilcoxen and many others
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A Porphyrin Iron(III) pi-Dication Species and its Relevance in Catalyst Design for the Umpolung of Nucleophiles (Johannes E. M. N. Klein and co-workers) @sileneengbers, @MossbauerLab, @lab_klein, @StratinghInst, @CMU_Chem #openaccess onlinelibrary.wiley.com/doi/…
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An S1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation (Yisong Guo and co-workers) @NCStateChem @Prof_SJE @BUChemisty @BUChemistry @MossbauerLab @CMU_Chem #AngewandteVIP #openaccess onlinelibrary.wiley.com/doi/…

An S=1 Iron(IV) Intermediate Revealed in a Non‐Heme Iron Enzyme‐Catalyzed Oxidative C−S Bond...

The first non-heme enzymatic S=1 Fe(IV) intermediate is discovered via transient kinetics and spectroscopic (Mössbauer, EPR, and XANES) characterizations. This novel species is a key intermediate to...

onlinelibrary.wiley.com
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Bernhard Research @ CMU
@bernlab14 Sep 2023
Replying to @Chemjobber
We use internet-connected Raspberry Pis with cameras to monitor almost everything in the lab. Added benefit of remote access: You can  be disappointed about your reaction's performance 24/7
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Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration (Chuo Chen and co-workers) @MossbauerLab @CMU_Chem @ncstatechem @UTSWGradSchool #openaccess onlinelibrary.wiley.com/doi/…

Repurposing Iron‐ and 2‐Oxoglutarate‐Dependent Oxygenases to Catalyze Olefin Hydration

It is shown that the 2-His-1-carboxylate coordination triad commonly deployed in Fe/2OG-dependent enzymes can be used as a general ligand system to support sequential hydrogen atom transfer and...

onlinelibrary.wiley.com
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We are getting ready to celebrate 40 years of Larry Que's career at @UMNChemistry. Larry has mentored 150 researchers in this time. What an amazing career and I can't wait to hear more about #iron #enzymes and #catalysis in this party. #LQfest
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Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron #Enzymes by Lide Cha, Jared C. Paris, Brady Zanella, Martha Spletzer, Angela Yao, Yisong Guo @MossbauerLab at @CMU_Chem, and Wei-chen Chang at @NCStateChem in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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Seeing the cis-Dihydroxylating Intermediate: A Mononuclear Nonheme Iron-Peroxo Complex in cis-Dihydroxylation Reactions Modeling Rieske Dioxygenases #Dihydroxylation #Mononuclear #Nonheme #IronPeroxo #Rieske #Mechansim pubs.acs.org/doi/10.1021/jac…

Seeing the cis-Dihydroxylating Intermediate: A Mononuclear Nonheme Iron-Peroxo Complex in cis-Dih...

Abstract. The nature of reactive intermediates and the mechanism of the cis-dihydroxylation of arenes and olefins by Rieske dioxygenases and synthetic nonh

pubs.acs.org
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Our website is officially live now! Check it out by clicking link below to find more about our symposium! cmugsspc.org
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Excited to share my lab’s first paper online today at Science. So proud of my team @JRui7001 @qun_zhao @ajhuls1 @noelnehc It was great fun to collaborate with Guo Group @MossbauerLab at CMU and Garcia-Borràs Group @MarcGBQ at IQCC-UdG on this project! science.org/doi/10.1126/scie…

Directed evolution of nonheme iron enzymes to access abiological radical-relay C(sp3)−H azidation

Engineered nonheme iron enzymes perform enantioselective radical azidation on aryl N-fluoroamide substrates.

science.org
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I'm excited to share with you our latest collaboration with the Liu group in @BUChemistry -- great work from Ronghai, my post-doc Andrew, and all authors! pubs.rsc.org/en/Content/Arti…

OvoAMtht from Methyloversatilis thermotolerans ovothiol biosynthesis is a bifunction enzyme: thiol...

Mononuclear non-heme iron enzymes are a large class of enzymes catalyzing a wide-range of reactions. In this work, we report that a non-heme iron enzyme in

pubs.rsc.org
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Join us for a virtual information session about our Ph.D. in Chemistry! Application fee waivers are offered to those who attend. Register for one of our three dates here: bit.ly/2Y1hbJu

Carnegie Mellon University Ph.D. in Chemistry Information Session

 

apply-dc-mcs.mcs.cmu.edu
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#ACSEditorsChoice #OA An Fe/2OG enzyme-catalyzed epoxidation, a biomimetic Lewis acid method of ring contraction, and Heck coupling approach leverages chemoenzymatic synthesis to prepare important molecules @MossbauerLab @NCStateChem @MKCMU @CmuScience ow.ly/kRbM50FdKlo
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A new Science study demonstrates that a core component of #SARSCoV2 replication and transcription relies on two iron-sulfur clusters. These clusters are targets for novel therapies against #COVID19, the authors say. fcld.ly/yuzaqu7
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Hi chemtweeps! As you know, we are moving our lab to @CMU_Chem this Fall. We are hiring two postdoctoral researchers to work on very exciting projects (involving Cu, obviously)! Please spread the word! If interested, please contact me via DM or email: [email protected]
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Today's #ChemSciPicks is from Zhi-Yong Yang, Dennis R. Dean, Brian M. Hoffman and Lance C. Seefeldt . They address the open question of the electronic structure of the active-site metal cofactor (FeV-cofactor) of resting-state V-dependent nitrogenase: pubs.rsc.org/doi/D0SC06561G
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Happy that this is out with my lab mate and first author @srisantitham!Some of the coolest mössbauer data I have seen. pnas.org/content/118/11/e201…

Postbiosynthetic modification of a precursor to the nitrogenase iron–molybdenum cofactor | PNAS

Nitrogenases utilize Fe–S clusters to reduce N2 to NH3. The large number of Fe sites in their catalytic cofactors has hampered spectroscopic invest...

pnas.org
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Alex Guo retweeted
PSU Bioinorganic@psunerdcircus23 Dec 2020
Due to the ongoing health situation caused by the corona virus, the 6th Penn State Bioinorganic Workshop will be offered virtually, tentatively June 2-8, 2021. sites.psu.edu/bioinorganic/
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CMU Chemistry is hiring! Link to application site here. apply.interfolio.com/79155
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