@MurthyLab

We are a neuroscience laboratory interested in neural mechanisms of social communication.

 Princeton, NJ
murthylab.princeton.edu
Joined April 2015
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How are neurons activated by sensory stimuli? For the past century, the only method for addressing this question has been neurophysiology.
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We are excited to announce that registration is open for the 2024 Neural Mechanisms of Acoustic Communication Gordon Research Conference. The preliminary program is now live: grc.org/neural-mechanisms-of… We invite everyone to apply! See you @ Sunday River, Maine, May 19-24, 2024.
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Murthy Lab retweeted
FlyWire@FlyWireNews12 Nov 2023
This might make you think twice next time you reach for the fly swatter. The whole brain wiring diagram of the fly! All 140,000 neurons and their 50M synapses are available to explore in Codex, the Connectome Data Explorer: codex.flywire.ai/ #sfn23
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We've updated our preprint on finding one-to-one mappings of DNN neurons and real visual neurons of fruit fly. --> 2x silenced data with new LC31 neuron type --> more LC neural recordings --> FlyWire connectome --> knockout training simulations Enjoy! tinyurl.com/5n7t6tpv
Benjamin Cowley@BenjoCowley21 Jul 2022
Excited to share a new manuscript! Deep nets are great at predicting visual neurons. Yet, they are unable to tell us which artificial neuron directly corresponds to a biological neuron… until now! biorxiv.org/content/10.1101/… (yes, that is indeed a fictive female fly, good guess!)
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Flies are highly visual animals. That’s obvious to anyone who has ever tried to swat one. So it should be no surprise that eyes are so prominent on the fly head.
By Sanjay Acharya - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=63862733

ALT By Sanjay Acharya - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=63862733

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By giving all #flyneuro labs access to the data when we began proofreading, science has proceeded alongside completion of the connectome. More papers highlighting the FlyWire resource coming soon … stay tuned!
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One quick teaser - @DudiFly and Kaiyu Wang identified nearly all sexually-dimorphic neurons brainwide - now possible to trace information flow for social communication and female-specific behaviors. Here is a subset of fru/dsx neurons (render from @alin1194):
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FlyWire connectome reveals how sensory signals are integrated to drive behavior, and how recurrence and feedback shape these sensorimotor pathways. So much science to come - lucky to have co-led the project with @SebastianSeung
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A major achievement for our community! So grateful to the worldwide FlyWire team who worked tirelessly to reach this milestone. And the beautiful EM data from Zheng et al. pubmed.ncbi.nlm.nih.gov/3003…

A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster - PubMed

Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only electron...

pubmed.ncbi.nlm.nih.gov
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Excited to announce the completion of the first adult brain connectome - FlyWire is the neuronal wiring diagram of a Drosophila melanogaster brain with >130K neurons and >32M synapses. Explore at codex.flywire.ai. Check out the preprints:
Sven Dorkenwald@sdorkenw30 Jun 2023
We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: codex.flywire.ai/ Reconstruction paper: biorxiv.org/content/10.1101/… Annotation paper: biorxiv.org/content/10.1101/… 1/6
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#flyneuro colleagues please share with your students. Michael Crickmore and @elliehoopla sent me their amazing students (thank you!) - @KyleThieringer is now off to do a PhD in neuroscience at @UW 🤩
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The Murthy Lab @PrincetonNeuro is looking for a research tech! Undergrads please apply! Join our diverse team to work on exciting projects uncovering the neural dynamics and circuit architecture underlying flexible social behaviors - apply here: research-princeton.icims.com…
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