sphingolipids, rare diseases, breaking lipid pathways
Switzerland
Joined June 2020
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Museer A. Lone retweeted
🔬 𝙉𝙚𝙬 𝙋𝙖𝙥𝙚𝙧 𝙋𝙪𝙗𝙡𝙞𝙨𝙝𝙚𝙙 𝙞𝙣 𝘾𝙚𝙡𝙡𝙨 𝙅𝙤𝙪𝙧𝙣𝙖𝙡
🎯 Intersection of Sphingolipid and Sterol Metabolism at the Level of Orm Proteins in Yeast
👥 Corresponding Author:
🧑Museer A. Lone (@MuseerSphinx)
🔗 Read the Full Article:
brnw.ch/21x2a5b
Yeast Orm1/2 proteins regulate sterol levels. A new twist to membrane homeostasis and lipid regulation #cholesterol#sphingolipids
🔬 𝙉𝙚𝙬 𝙋𝙖𝙥𝙚𝙧 𝙋𝙪𝙗𝙡𝙞𝙨𝙝𝙚𝙙 𝙞𝙣 𝘾𝙚𝙡𝙡𝙨 𝙅𝙤𝙪𝙧𝙣𝙖𝙡
🎯 Intersection of Sphingolipid and Sterol Metabolism at the Level of Orm Proteins in Yeast
👥 Corresponding Author:
🧑Museer A. Lone (@MuseerSphinx)
🔗 Read the Full Article:
brnw.ch/21x2a5b
Pre-print alert! we try to understand how mutations in Serine-plamitoyltransferase (SPT) subunits shape sphingolipid metabolism in #sensoryneuropathy #ALS n #sensorymotor neuropathy.
Sphingolipid remodelling in SPT-related neuropathies biorxiv.org/content/10.64898…
Museer A. Lone retweeted
Excited to share my invited JLR Lectureship article — a big-picture, and somewhat provocative, take on why evolution chose sphingolipids…and the costs that choice carries. doi.org/10.1016/j.jlr.2026.1…
Fully funded PhD (3y)
I’m recruiting a PhD student in lipid metabolism & ALS at University Hospital Zurich/ University of Zurich.
Lipidomics • MS • neurons
🇨🇭/🇪🇺 only · immediate start
DM for details. @SL_Biology @Lipids_IdISBa @lipidmaps
Impact factors rarely capture groundbreaking work. In a study led by X-less Michele Visentin and myself, we identify acylome switching as early marker of chronic kidney disease with HFD.
Check it out! #KidneyResearch #Metabolism #Lipidomics
nature.com/articles/s41598-0…
Museer A. Lone retweeted
Glycosphingolipids in neurodegeneration? 🧠 Lipids may hold the key to understanding Alzheimer's, Parkinson's, and beyond. Discover how glycosphingolipids influence neurodegeneration and explore their potential as therapeutic targets in this latest review.
sciencedirect.com/science/ar…
Museer A. Lone retweeted
In einer Studie im @NatureMedicine zeigen Forschende von @ETH, @UZH_ch, @UniSpitalBasel und KSBL einen neuen, vielversprechenden Ansatz: Digoxin löst Klümpchen von zirkulierenden Krebszellen im Blut auf und reduziert so die Gefahr von Metastasenbildung.
usz.ch/krebszell-cluster-auf…
Museer A. Lone retweeted
The therapy’s developer is now planning a new Phase 3b trial that it hopes will pave the way toward approval. It’s expected to enroll about 200 people with ALS. Learn more: bit.ly/40wfIIY
#AmyotrophicLateralSclerosis #ALSDisease #ALSTreatment #ALSResearch #ClinicalTrial
Museer A. Lone retweeted
What is happening? HandMol is happening!
Coming soon, multiuser, immersive, interactive simulations.
Museer A. Lone retweeted
Molecular dynamics simulations in mixed reality!
With @labriataphd and @lucien_krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies.
Stay tuned, lots of cool stuff coming soon!
@threejs #WebXR #Quest3
Museer A. Lone retweeted
Age related impairments in muscle function arise due to a reduction in CERS1, thereby underlining the importance of the sphingolipid biosynthesis pathway in age-related muscle homeostasis elifesciences.org/reviewed-p…
Prof. Lavade, absolutely a pioneer in the field!
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Museer A. Lone retweeted
Happy to share that our #lipidtime work on the conformational dynamics of lipid transport proteins by @sriraksha616 @AndreaDiLuca7 @dani_alv4 and @ATJohnPeter is now out in @PLOSBiology! Big thanks to collaborators @Gio_Dangel0 @GehinCharlotte @MuseerSphinx for the support!
How do #LipidTransferProteins (LTPs) coordinate exchange of #lipids between different cellular organelles? @LabVanni &co study unrelated #LTPs, identifying conserved mechanisms of lipid transfer that correlate with conformational properties #PLOSBiology plos.io/3XbcQzq
Thank you @shaha_kash and @KhalifaUni UAE for the invitation. We had a great conference.
Dr @MuseerSphinx delivering a Keynote on “Decoding the sphingolipid enigma: bridging neurodegeneration, metabolism, and therapeutic frontiers” at the 3rd UAE Anatomy & Cellular Biology Conference #acbc held at @KhalifaUni
Museer A. Lone retweeted
Authors of this study show that recurrent de novo SPTLC2 variant causes childhood-onset amyotrophic lateral sclerosis (ALS) by excess sphingolipid synthesis
jnnp.bmj.com/content/early/2…
@MuseerSphinx
New genes and mutations that cause childood form of ALS. Our collaborative efforts bearing fruit. Thank you @JNNP_BMJ and all the collaborators. #ALS #sphingolipids #rarediseases
Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis
jnnp.bmj.com/content/early/2…
@MuseerSphinx
Museer A. Lone retweeted
Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis
jnnp.bmj.com/content/early/2…
@MuseerSphinx
Museer A. Lone retweeted
Lidia Gall, who died last October, is an inventor of electrospray ionization mass spectrometry.
#InternationalWomensDay
en.wikipedia.org/wiki/Lidia_…
Museer A. Lone retweeted
Auch ein Projekt des USZ wird gefördert: Im Projekt "Multidimensional models for in vitro screening of endocrine disrupting agents" von Constanze Hantel kommen In-vitro-Modelle der Nebenniere und der Bauchspeicheldrüse anstelle von Tieren zum Einsatz.
🎉 We're thrilled to announce the #funding of five #research projects putting #3Rs methods into effective practice! Stay tuned for groundbreaking advancements in research! Read the press release here: swiss3rcc.org/media/pages/ne… #3Rs #replace #reduce #refine #Innovation