Neil Murphy retweeted
And thanks to the brilliant @CancerGrand team at CRUK for their total support since Mutographs started, as well as wonderful scientific journey with @sangerinstitute and @UCSD colleagues (esp @drsarahmoody), partners in the 11 countries, and all the great team @IARCWHO.
Congrats #CancerGrandChallenges team Mutographs on their paper in @Nature today!
Showing the power of their mutational epidemiology approach, they uncovered mutational signatures underlying global variance in #KidneyCancer incidence rates.
Read: nature.com/articles/s41586-0… (1/5)
Neil Murphy retweeted
1/4 Excited to share our latest preprint where we used observational and Mendelian randomization methods to explore the role of metabolites as intermediates between adiposity and endometrial cancer using data from UK Biobank (@uk_biobank). medrxiv.org/content/10.1101/…
Neil Murphy retweeted
📢 Think body shape not (just) #BMI
#obesity subtypes & #ColorectalCancer just out in @ScienceAdvances
👏 @LPeruchet @AnjaSedlmeier
@RCarrerasTorres et al.
@IARCWHO #NCMTeam
🙏 @Institut_cancer
science.org/doi/10.1126/scia…
Neil Murphy retweeted
The accompanying Editorial: Identifying Genetic Loci Associated with an Increased Risk for Early Onset Colorectal Cancer
annalsofoncology.org/article…
#OpenAccess in Annals of Oncology, investigators report on genome-wide association & Mendelian randomization analyses to identify causes EOCRC. 2 novel risk loci are proposed & evidence is found on the impact of modifiable lifestyle & metabolic targets
annalsofoncology.org/article… 2/2
Neil Murphy retweeted
Important new study from @IARCWHO which "provides new insights into people’s genetic susceptibility to early-onset bowel cancer, as well as strengthening our knowledge of the modifiable risk factors involved, notably body weight and alcohol intake."
wcrf.org/latest/news-and-upd…
Neil Murphy retweeted
#OpenAccess in Annals of Oncology, investigators report on genome-wide association & Mendelian randomization analyses to identify causes EOCRC. 2 novel risk loci are proposed & evidence is found on the impact of modifiable lifestyle & metabolic targets
annalsofoncology.org/article… 2/2
Neil Murphy retweeted
The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally and the European cancer mortality predictions for the year 2024 published in the March 2024 issue of Annals of Oncology showed unfavorable trends annalsofoncology.org/article…
1/2
Neil Murphy retweeted
1/9
🆕📰
Association between pre-diagnostic circulating #lipid #metabolites and #ColorectalCancer #risk
New publication from @ImperialBRC @ImperialSandC Research Fellow @harewoodr & @IARCWHO et al colleagues
Study funded by @wcrfint @EU_Commission
doi.org/10.1016/j.ebiom.2024…
Neil Murphy retweeted
IARC scientists &partners reveal🆕findings about genetic & lifestyle risk factors of early-onset #ColorectalCancer
Results may improve primary prevention, help prioritize screening
📰:@Annals_Oncology
@WCRF_UK @wcrfint @Institut_cancer @CR_UK @CRUKresearch
iarc.who.int/news-events/gen…
A new study co-led by Fred Hutch's @PetersRiki provides insights into what's driving #colorectalcancer in people who are often too young to qualify for preventive screening. Alcohol consumption and obesity are two important, but modifiable, risk factors. bit.ly/4c1HD72
Neil Murphy retweeted
A new study co-led by Fred Hutch's @PetersRiki provides insights into what's driving #colorectalcancer in people who are often too young to qualify for preventive screening. Alcohol consumption and obesity are two important, but modifiable, risk factors. bit.ly/4c1HD72
Neil Murphy retweeted
Genome-wide association study and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer
💥The incidence of early-onset CRC is increasing worldwide.
A comprehensive investigation into the aetiology of this👇
annalsofoncology.org/article…
Neil Murphy retweeted
🔔🚨
Early onset colorectal cancer (EOCRC)
2 recent studies @Annals_Oncology and @JCOOP_ASCO
✅1️⃣Genome-wide association study and Mendelian randomization analyses
➡️6,176 EOCRC cases and 65,829 controls
➡️two novel risk loci for EOCRC at 1p34.1 and 4p15.33
➡️a deleterious coding variant at MUTYH
➡️new EOCRC susceptibility genes: TGFβ, SMAD, BMP, and PI3K signaling, insulin signaling and immune/infection-related pathways
➡️higher levels of body size and metabolic factors (body fat percentage, waist circumference, waist to hip ratio, basal metabolic rate, and fasting insulin), higher alcohol drinking and lower education attainment > increased EOCRC risk
👉annalsofoncology.org/article…
✅2️⃣Demographic differences and outcomes
➡️73,378 patients with EOCRC
➡️incidence and mortality rates higher in rural areas
➡️non-Hispanic Black ethnicity and uninsured patients > worse survival
➡️Married status> better survival
👉ascopubs.org/doi/10.1200/OP.…
@myESMO @ESMO_Open @ASCO @ASCOPost @JCO_ASCO @JCOPO_ASCO @NCIResearchCtr @theNCI @NCCN @EORTC @GlobalCRC @ColonCancerCoal @ColonCancerFdn @CCAlliance @DFarberYoungCRC @EdinUni_IGC @NCIEpiTraining @UKCGG @DrDubardGault @DenizCanGuven1 @dr_yakupergun @DrYukselUrun @yekeduz_emre @KaracinCengiz @osutcuoglu @Lynchsyndromirl @CGAIGC @OncoKB @insightmeeting @EHTG_Tweets @McVeighTerri @swatigp @meghar111 @LValleResearch @kevinjmonahan @MattYurgelun @daniela_oaks @KimmieNgMD @marklewismd @OncoAlert @oncodaily @OncBrothers @OncoViews
#Cancer #Oncology #youngonset #genetics #hereditary #familial #Colon #colorectalcancer #MedX #MedTwitter
Neil Murphy retweeted
important new insights re #eoCRC
#HCP - Take the time during #ColorectalCancerAwarenessMonth to learn more about #eoCRC
#HereditaryGICancer
Wow, what an endeavor in EOCRC!
Hot off the press! TL;DR?
🧬 GWAS meta-analysis of > 70,000 CRC cases
🧬 2 new gene loci (1p34.1 and 4p15.33)
Also, EOCRC associated with
🍟 Metabolis (fat% and others)
🍇 Alcohol
🎒 Schooling
@CGAIGC @FightCRC
annalsofoncology.org/article…
Neil Murphy retweeted
A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator medrxiv.org/cgi/content/shor… #medRxiv
Neil Murphy retweeted
Incredible scenes from Tipperary today
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Neil Murphy retweeted
Brilliant seminar by Richard Peto @HarvardChanSPH about the influence of residual confounding in observational epidemiological studies. Compelling actual and hypothetical examples immediately suggest sensitivity analyses explicitly for this should be /cont youtube.com/watch?v=B0ZpenVs…
Neil Murphy retweeted
Ultra-processed foods (UPFs) are apparently the new poison, and a recent @bmj_latest report by @rebeccacoombes suggests conflicts of interests in the “expert” views presented @smc_london that weren’t enthusiastic enough in promoting this notion. bmj.com/content/383/bmj.p251… /cont
Neil Murphy retweeted
1/10: New commentary published in Obesity this week discussing the challenges and serious biases of nonlinear Mendelian randomization (MR) methodologies: onlinelibrary.wiley.com/doi/…
Neil Murphy retweeted
Come and join our Team. My time at IARC is soon coming to an end but was fortunate to be supervised by Neil!
Neil Murphy retweeted
Today, the flagship paper of the @uk_biobank Pharma Proteomics Project was published in @Nature.
nature.com/articles/s41586-0…
The results are fully browsable at ukb-ppp.gwas.eu.
The underlying protein measures will become available to UKB researchers in the next few weeks.