@NccAcc

Twitter is dead, find me at https://xitter.cf/t.co/gIJVhVbCKn Now: Postdoc @CRGenomica. Previously: @EMBO Postdoc Fellow, PhD @EMBL. Semi-Professional Pizza Enthusiast.

 Barcelona, Spain
ni-ar.github.io/
Joined February 2014
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  • Followers468
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.@GoogleDeepMind are you planning to release #AlphaGenome predictions for each 1Mb bin of the human genome at some point? It would be great to have them in @ensembl or @ucsc genome brower. (Similarly to AlphaFold predictions for all proteins on UniProt) Thanks!
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Earlier this year, I learned I have a pathogenic variant in BRCA2, which gives me a very high lifetime risk of breast cancer (55-69%), as well as an increased risk of ovarian cancer (12-29%) and pancreatic cancer (5-10%). 🧵1/ …
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Max Jaderberg
@maxjaderberg11 Nov 2024
Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmind/a… 1/2

GitHub - google-deepmind/alphafold3: AlphaFold 3 inference pipeline.

AlphaFold 3 inference pipeline. Contribute to google-deepmind/alphafold3 development by creating an account on GitHub.

github.com
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Niccolò Arecco retweeted
PayerLab@PayerLab3 Oct 2024
Xciting news + Jobs alert! 🚨 After wonderful years at @CRGenomica, we are relocating beginning 2025 to @ChuSteJustine at @UMontreal. If you want to be part of @payerlab 2.0, come and join us! We are hiring at all levels – see job ads in the thread 🧵below. 👇 1/5
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This is exciting!
Pushmeet Kohli
@pushmeet13 May 2024
We love the excitement & results from the community on AlphaFold 3 and are doubling the AF Server daily job limit to 20. Happy to also share that we're working on releasing the AF3 model (incl weights) for academic use, which doesn’t depend on our research infra, within 6 months.
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THIS! 👇
This Post is from an account that no longer exists. Learn more
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Where's the code+params? Please!
Google DeepMind
@GoogleDeepMind8 May 2024
Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬 Here’s how we built it with @IsomorphicLabs and what it means for biology. 🧵 dpmd.ai/3URDiNo
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"2/3 of of alternative TF isoforms exhibit differences in one or more molecular activities" biorxiv.org/content/10.1101/…

Widespread variation in molecular interactions and regulatory properties among transcription factor...

Most human Transcription factors (TFs) genes encode multiple protein isoforms differing in DNA binding domains, effector domains, or other protein regions. The global extent to which this results in...

biorxiv.org
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Luciano Di Croce@ludicroce7 Mar 2024
Very happy to see our work on the unexpected role of splicing in regulating Polycomb assembly, occupancy, dimerization and histone mark deposition. Great team work with @mirimiam, @NccAcc, @Ivuaenneo, among others! sciencedirect.com/science/ar…
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For the busy people with no time, Ivano made this great meme to capture the essence of our findings 😎
Ivano Mocavini@Ivuaenneo7 Mar 2024
PRC2 with splicing characteristics Our story is finally out on @MolecularCell TL;DR:
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If memes aren't really your thing (🙄) you can admire our @MolecularCell cover proposal made by the super talented Iris Joval (irisjoval.com) inspired by the Bauhaus movement of the 1920s
Here we witness a vivid representation of those two concepts at play in the nucleus. PRC2 component SUZ12 is present in two alternative splicing isoforms depending on SUZ12 fourth exon (represented by squares) On the one hand, the ancestral isoform mainly acts in a monomeric complex (red semicircle) – that methylates nucleosomes on vast portions of the genome. On the other hand, the novel isoform is able to focus PRC2 activity on gene promoters, by favoring PRC2 dimerization. Exon 4 is constitutively included in non-placentals vertebrates ( kangaroo) only becomes alternative in placental mammals (deer) where the two isoforms are coexpressed and contribute to modify chromatin.

ALT Here we witness a vivid representation of those two concepts at play in the nucleus. PRC2 component SUZ12 is present in two alternative splicing isoforms depending on SUZ12 fourth exon (represented by squares) On the one hand, the ancestral isoform mainly acts in a monomeric complex (red semicircle) – that methylates nucleosomes on vast portions of the genome. On the other hand, the novel isoform is able to focus PRC2 activity on gene promoters, by favoring PRC2 dimerization. Exon 4 is constitutively included in non-placentals vertebrates ( kangaroo) only becomes alternative in placental mammals (deer) where the two isoforms are coexpressed and contribute to modify chromatin.

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Niccolò Arecco retweeted
Molecular Cell@MolecularCell6 Mar 2024
Online Now: Alternative splicing decouples local from global PRC2 activity dlvr.it/T3jTqH
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Manuel Irimia@mirimiam6 Mar 2024
The peer-reviewed version of our study on how an eutherian-specific isoform of SUZ12 decouples local from global PRC2 activity is out in @MolecularCell! Great work by @NccAcc & @Ivuaenneo, a perfect collaboration with the polycomb masters @DiCroceLab! 👉authors.elsevier.com/c/1iiyW…
Manuel Irimia@mirimiam2 May 2023
🚨 New pre-print from the lab! Alternative splicing decouples local from global PRC2 activity Great work from @NccAcc and @Ivuaenneo, in close collaboration with the Polycomb masters of the @DiCroceLab at @CRGenomica! Tweetorial by @NccAcc. Additional #PanAS thoughts 👇 1/5
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SUZ12 gene splicing impacts PRC2 assembly and H3K27me3 landscape! Joint effort from @mirimiam & @DiCroceLab labs from @CRGenomica Pre-print summary ​​⬇️ 1/9 biorxiv.org/content/10.1101/…

Alternative splicing decouples local from global PRC2 activity

The Polycomb repressive complex 2 (PRC2) mediates epigenetic maintenance of gene silencing in eukaryotes via methylation of histone H3 at lysine 27 (H3K27). This complex interacts with sets of...

biorxiv.org
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A big thanks goes also to Enrique Blanco, Cecilia Ballaré, @SoBonnal, @mirimiam, and @ludicroce for their exceptional support. And @EMBO and @CRGenomica for funding my postdoctoral work.
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And here's the paper in its final form! 🥳 authors.elsevier.com/c/1iiyW…
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Today in partnership with @IsomorphicLabs, we're sharing progress on the next generation of #AlphaFold. 🧬 Our new model greatly expands coverage of structure prediction beyond proteins to other key biomolecular classes. How could it help scientists? 🧵 dpmd.ai/alphafold-progress
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NASA en español
@NASA_es12 Jul 2023
¡Felicidades, @nasawebb! 🥂 Celebremos un año de operaciones científicas echando un nuevo vistazo al nacimiento de estrellas similares al Sol en esta detallada imagen de Rho Ophiuchi, la región de formación estelar más cercana a la Tierra: go.nasa.gov/44ELqml
Dobles chorros rojos opuestos provenientes de estrellas jóvenes llenan la mitad superior más oscura de esta imagen, mientras que una estructura brillante de color amarillo pálido, similar a una cueva, está en el centro inferior, inclinada hacia las dos en punto, con una estrella brillante en su centro.

ALT Dobles chorros rojos opuestos provenientes de estrellas jóvenes llenan la mitad superior más oscura de esta imagen, mientras que una estructura brillante de color amarillo pálido, similar a una cueva, está en el centro inferior, inclinada hacia las dos en punto, con una estrella brillante en su centro.

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I have written a very short overview of the story the sandy blind mole rat - an endemic species of Ukraine luckily going to be extinct. It's a story about an animal as well as the people trying to protect it during the turmoil of XX and XXI centuries: github.com/zolotarovgl/sandy…
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The #EMBLChromatin conference was a blast! Extremely thankful to the organizers and poster judges for giving me a chance to present our work at @CRGenomica
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Thanks to @trincookis for the picture!
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If you're attending #EMBLChromatin come to poster 60 on Wednesday to learn more about how alternative splicing is diversifying polycomb activity and shaping the epigenetic landscape!
Niccolò Arecco@NccAcc2 May 2023
SUZ12 gene splicing impacts PRC2 assembly and H3K27me3 landscape! Joint effort from @mirimiam & @DiCroceLab labs from @CRGenomica Pre-print summary ​​⬇️ 1/9 biorxiv.org/content/10.1101/…

Alternative splicing decouples local from global PRC2 activity

The Polycomb repressive complex 2 (PRC2) mediates epigenetic maintenance of gene silencing in eukaryotes via methylation of histone H3 at lysine 27 (H3K27). This complex interacts with sets of...

biorxiv.org
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