@NogalesLab

The Nogales Lab at UC Berkeley. #CryoEM #Transcription #Microtubules #ChromatinModification #Telomerase Twitter account managed by lab members.

 Berkeley, CA
cryoem.berkeley.edu/
Joined January 2019
  • Tweets642
  • Following106
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Thrilled to share our latest work, led by @aryandtaheri and @jpeukes! Using #cryoEM and #cryoET, we reveal how KIF21B’s distal tail engages multiple tubulin dimers along a protofilament, enabling persistent microtubule attachment and crosslinking. biorxiv.org/content/10.64898…
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Thrilled to share our collab with @GraceHibshman and the Shipman lab! Type IX retron-Kva2 structure reveals phage detection via an HTH fold, not a primary sequence. We computationally designed triggers that program bacteria cell death, pointing toward designer antimicrobials.
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biorxiv.org/content/10.64898…

Higher-order assembly of a type IX retron enables exploitation for designer antimicrobials

Bacterial defense systems provide a rich reservoir for biotechnological innovation. Retrons are tripartite abortive infection systems that detect phage invasion using reverse-transcribed DNA (msDNA),...

biorxiv.org
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🧵 New paper alert! Today on bioRxiv, we show how a microtubule (MT) associated protein, MTCL1, links 2 regulatory layers: mechanical MT stabilization and writing of then tubulin code. A multi-lab effort driven by @Juanmabertoldi1 and Julie Dang spanning atoms to organisms. 1/n
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Full text here: biorxiv.org/content/10.64898… @Juanmabertoldi1, Julie Dang, Mert Golcuk, Eva Lanska, @lopesdanilo11, Veronique Henriot, Jingyi Luo, @RuiZhangWUSTL, @JeffTiLab, @CarstenJanke, Zdenek Lansky, @PittGurLab, @filodelbene, @NogalesLab 10/n

Coupling of tubulin acetylation to microtubule stabilization through molecular mimicry

Microtubules support diverse cellular functions through regulation by microtubule-associated proteins and tubulin post-translational modification, yet how these two layers are mechanistically...

biorxiv.org
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#microtubules #cryoEM #tubulincode #cellbiology #neuroscience #zebrafish #structuralbiology #biorxiv 11/n
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Molecular imaging pioneer Eva Nogales awarded the 2026 Vanderbilt Prize in Biomedical Science news.vumc.org/2026/06/30/mol… I am truly honored to receive this prize and incredibly grateful to have worked with so many talented lab members over the years.🙏👩‍🎓🧑‍💼

Molecular imaging pioneer Eva Nogales awarded the 2026 Vanderbilt Prize in Biomedical Science

The Vanderbilt Prize in Biomedical Science recognizes scientists who have a stellar record of research accomplishments.

news.vumc.org
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Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! biorxiv.org/content/10.64898…
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Congrats to Ana Galic and Kevin Li, who just graduated with honors in MCB, and to the brand new Dr. Trinity Cookis @trincookis 👨‍🎓👩‍🎓👩‍🎓🤩. Very best wishes for your next endeavors 💝.
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@berkeleyMCB
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Congrats to my @berkeleyMCB colleague @AndyMartinLab who just received the Dorothy Crowfoot Hodgkin Award of the @ProteinSociety. Andy's studies have made the proteasome one of the best understood molecular machines in biology. Well deserved!! 🥳🥳
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Another fabulous PEW meeting, this year at Palm Springs. So lovely to share time with both exlab members @vignesh_k757 and @kellogg_liz and @UCBerkeley colleagues. LatinAmericanFellows, please send me photos by email! Science was simply wonderful!! 🧬🥇
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