@NovoaLab

Tweets from lab members of the Epitranscriptomics & RNA Dynamics lab @CRGenomica

 Barcelona, Spain
crg.eu/en/programmes-groups/novoa-lab
Joined December 2019
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(8/8) This project was co-led by Mie Monti and Hasan Yilmaz in a fruitful collaboration between the @NovoaLab, @ImmaginaBiotech and the #AnaSoares Lab.💃
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(7/8) Overall, tRIBO-seq provides a simple way to profile the active tRNAome, capturing abundance, modifications and fragmentation from actively translating ribosomes.
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(6/8) Under basal conditions, the ribosome-associated tRNA pool largely matches the total cellular tRNA pool. But under stress, the picture changes... have a look at the paper to see how.
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(5/8) Using @nanopore sequencing allows us to capture multiple layers of tRNA biology in a single experiment: • tRNA abundance • modification signatures • fragmentation patterns All directly from ribosome-associated tRNAs.
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(4/8) tRIBO-seq builds on RiboLace technology from to pull down active ribosomes. Using ~15× less starting material, we recover comparable ribo-tRNA amount to polysome purification - with a much faster protocol. And yes, recovered tRNAs correlate well with the polysome-derived.
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(3/8) To address this, we developed tRIBO-seq alongside IMMAGINA Biotech. The idea is simple: • capture actively translating ribosomes • isolate their associated native tRNAs • sequence them using nanopore This provides a direct view of the ribo-tRNAs.
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(2/8) tRNAs deliver amino acids to ribosomes according to mRNA codons. But most studies measure total cellular tRNAs, not the tRNAs actually engaged with translating ribosomes. This makes it hard to understand the role of the active tRNA pool in translation 🧐
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New preprint released 🪇 Which tRNAs are used by ribosomes during translation? We introduce tRIBO-seq, a nanopore method to sequence ribosome-associated tRNAs and track how the active tRNA pool changes across stress conditions. biorxiv.org/content/10.64898… A thread 🧵
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Please join us in congratulating Gregor @GDiensthuber on successfully defending his PhD 🎓 A proud moment for the whole lab 🧬 Thanks for being such a great colleague and lab mate! We’re excited to see where your science takes you next! 🚀
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Last week our Lab participated in the @CRGenomica PhD Symposium! Huge congrats to Cristina Petrella and Leda Katopodi for their successful talks, and @GDiensthuber for reaching the final stage of his PhD! Big thanks to the CRG and the PhD community for a science-packed event👏
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It was our pleasure to host James Bryson (BRIC, Copenhagen) at @CRGenomica through the EU-LIFE Postdoctoral Exchange Program! Thanks to James for presenting his work on advanced CRISPR tools for epitranscriptomic research, and to @EULIFE_news for this opportunity!🧬✈️#EULIFE #CRG
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🧬 New review on nanopore base-calling models is out! Congrats to Sonia Cruciani (former Novoa Lab PhD, now postdoc at the Deplancke Lab, EPFL) and @EvaMariaNovoa 📖 Read it here:nature.com/articles/s41580-0… 👏👏👏
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Replying to @NovoaLab @mie_monti
Always great to connect and share science with colleagues from the Genome Biology Program at @CRGenomica ! 🧫🔬🏝️
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🧬Novoa Lab had a great time at the Genome Biology Program Retreat'25! Big thanks to the organisers for such an inspiring and fun event 👏 Congrats to @mie_monti for being part of the organising team and to @oguzhanbegik for giving a fantastic talk!
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Novoa Lab joined the PRBB Open Day 2025🔬🧬🌊 @the_prbb to share our passion for RNA research with the public. Thanks to everyone who came to explore science with us and thanks organisers for making this event possible! #PRBBOpenDay #OpenScience
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A little lunch selfie to mark our return online after summer break! 🌱 Exciting projects ahead—stay tuned for updates from the Novoa Lab🤙🏻
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Fresh preprint from the @NovoaLab!😀📌 Do you want to barcode up to 96 #RNA samples in your #nanopore flowcells? How well do RNA #modification-aware models perform? What if there is #noBasecallingModel for your modification-of-interest? Find it out here!😊biorxiv.org/content/10.1101/…

Systematic benchmarking of basecalling models for RNA modification detection with highly-multiple...

Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technolo...

biorxiv.org
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Last month, the @NovoaLab attended the Premis Nacionals de Recerca ceremony to celebrate @EvaMariaNovoa receiving the National Young Researcher Award!🎉👏 Huge congratulations again, Eva - an incredible and well-deserved recognition! 🧬🏆 – at Barcelona, Cataluña
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Another epic Novoa Lab retreat in the books! A big thank you to everyone who made it such a success — from the science-packed discussions and hands-on workshops to the brainstorming, games, sunny pool sessions, and delicious BBQs. And special thanks to the organizers!
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VERY excited to share SeqTagger with the world! If you want to learn more about our super-fast and accurate demultiplexing tool for direct RNA-sequencing (DRS), check out the thread below. bit.ly/3ClVYxG (1/15) 🧵
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