Nitin Karandikar

Dinner with dear mentors, coffee with dear mentees, live posters, live talks, lots of (a)live chats... must be @TheUSCAP - looking forward to the @UIPathology dinner tonight.

GREAT to be LIVE in LA, doing pre-meeting meetings, awaiting the start of USCAP2022. USCAP2020 was one of the last live conferences before the pandemic tornado hit us. Awaiting the arrival of the @UIPathology team and Pathology colleagues from world over. See y’all soon! 😁

A weekend flow case after a long time.... Here is a quick-and-dirty slide (sorry for the expeditious cluttered labeling). History on the slide. What do you think about the red population? #GoWithTheFlow @UIPathology

Seeking inspiration (or at least wakefulness 😁) to start attacking a brand new grant proposal....

OK - doing this after a long break. Look at the image and see what you think about the red population. Diagnosis? Don't get to see these often anymore [unlike in the mid-90's when we might see 2-3 cases/week at some centers]. So throwing this one into #PathTwitter. #GoWithTheFlow

It’s so cold, even our “0” is negative 😁🥶🥶🥶... stay warm y’all!

Agree. There is variability. Need to use combination of markers and do intracellular kappa/lambda staining to be definitive. In our study of ~100 BM specimens with polytypic/"normal" plasma cells, CD117 was uniformly negative. See: onlinelibrary.wiley.com/doi/… and attached figure.

ONE-TWO PUNCH: I think the image says it all! Second dose done. Feeling highly privileged, proud and grateful 🙏🙏👏👏 So many people collaborated to make this possible. Simple message/plea: Please take the vaccine whenever offered. It's the only way to bring this under control.

The key feature is the predictable MATURATION SPECTRUM reminiscent of normal thymocytes [see arrows in the image]. I find the CD3/CD1a and the CD4/CD8 dotplots most useful. These four markers will differentiate thymocytes from neoplastic T lymphoblasts in (almost) all cases.

#GoWithTheFlow @UIPathology Back to the CD10+ theme [although we don't pay too much attention to this marker in this scenario]. Here is another classic Friday evening urgent call. Young man, anterior mediastinal mass... 1. Are you seeing the tumor cells? 2. Likely diagnosis?

Nice pics Andrew. Agree - some great places/activities just within a 30-90 minute radius. From city to corn fields to wildlife/rivers/nature... I learned some new tidbits in this Meet-and-Greet hosted by our residents as well: youtube.com/watch?v=DYDBf4z6…

Back to #GoWithTheFlow #hemepath @UIPathology Flow findings from bone marrow specimen. 45 yr-old patient. Focus on the red population. Most likely diagnosis?

These are butterfly eggs in a more “natural” location.

The plausible but wrong answer took an early lead and edged out the correct answer. These are eggs on a window curtain (!), likely butterfly?... nature using whatever is available to continue the fight for survival.....

Stealing this “gross photograph” from a friend of mine in India. It’s the dreaded Friday evening urgent call: Examine this carefully and diagnose what it is.... 😁 #PathologyEyeForTheNonPathologyGuy? Answer on Monday. Happy Labor Day weekend.

#GoWithTheFlow #hemepath #Freeflowin' New YouTube video entry continues this week's hematogone theme. If you know your hematogones intimately, you will not miss (or misdiagnose) even the tiniest population of a B lymphoblastic leukemia. youtu.be/QVm-LjdQnl0

Thanks for the responses. YES: the red population represents hematogones [non-neoplastic maturing B-lineage precursors] in "B-cell school" learning to become naive B cells going into the immune system to face antigenic challenges of the future. Image highlights notable features.

#GoWithTheFlow @UIPathology Here’s a question that straddles Pathology (#hemepath) and Immunology. In the attached image, focus on the red population and answer the associated poll.

After the introductory #GoWithTheFlow videos, starting a new sub-series called #FreeFlowin’ 😎 For the kickoff of this “Video Atlas” we have visiting expert Dr Buddy Fuda from @HemepathUTSW give us a deeper-than-deep look at CD5+ B-cell lymphomas: youtu.be/zcaMP39TKQ4