Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab) header
Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab) profile picture

Working on brain tumours like #DMG #DIPG in children and young people, @CR_UK Career Establishment Award recipient 🏳️‍🌈🇮🇳🇭🇰🇲🇾🇸🇬🇺🇲🇬🇧

Oxford, England
Joined September 2017
Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)Photo by Manav Pathania | @manavpathania.bsky.social (@Pathania_Lab)
First Pathania Lab paper in @CD_AACR: bit.ly/3K5xA3J. We developed 16 mouse models of various subtypes of pediatric high-grade glioma— mirroring their different H3 mutant contexts, anatomical compartmentalizations and co-segregating partner alterations. Thread below 1/17
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Manav Pathania | @manavpathania.bsky.social retweeted
Kemi, congratulations on leading a major British party as a Black Woman. It takes real talent to rise to where you are and deceit is what it takes to rise as a Black leader in a western Conservative Party. It is a pity the climb did not leave room for a history book and since you chose to argue in the language of history, let us do the history. Let’s dissect your verbal diarrhea point by point. Everyone participated." Slavery existed on every continent. So did war, and nobody calls a village feud the World War. The transatlantic trade ran for 366 years (1501 to 1866) and put about 12.5 million Africans on ships, of whom about 1.8 million died before they saw the Americas, according to the Trans-Atlantic Slave Trade Database. It ran through joint-stock companies, chartered monopolies, Lloyd's underwriters and acts of Parliament. It was hereditary, because the law made the child of an enslaved mother property from birth. It was racial, because a whole continent was defined as chattel. No other system in history combined those features at that scale. Dissolving all of it into "people from every continent" is far worse than intellectual dishonesty. Britain was a market leader, not a participant. British ships carried about 3.2 million Africans, second only to Portugal and Brazil. The Treaty of Utrecht (1713) gave Britain the asiento, a thirty-year monopoly to supply 4,800 enslaved Africans a year to Spanish America. The Royal African Company, chartered in 1672 and headed by the Duke of York, later James II, branded its captives "DY". During Edward Colston's years in its leadership it shipped about 84,000 people, and roughly 19,000 died on the way. You say British taxpayers should not answer for what happened before they were born. They did. In 1833 Britain borrowed £20 million to compensate slaveholders, and taxpayers serviced that loan until 2015, including the descendants of the enslaved. So the principle you invoke was not applied when the cheque went to slaveholders. It only appears when the cheque changes direction. "Navel-gazing" is a curious charge from someone whose party spends more energy on the past (Empire nostalgia, culture war crusades) than most of those you accuse. Defend Britain if you must. But do not use your Nigerian name as the permission slip for arguments Nigerians know better than anyone.
Slavery was an evil in which people from every continent and region participated. We should be honest about the whole history, not select the parts that are politically convenient today, especially given Britain's leading role in ending the transatlantic slave trade. If Caribbean countries are asking Britain for a formal apology for Britain’s role in the transatlantic slave trade, will they also be asking the same of the descendants of African kingdoms, rulers and merchants who captured, sold and profited from the trade? On demands for reparations, whether through cash or debt relief, we have been down this track before. Twenty-five years ago, Jubilee 2000, Drop the Debt and Make Poverty History argued that cancelling the debts of poorer countries would give them a fresh start. More than $100 billion of debt was eventually written off, but many of those countries have since built up even bigger debts. Labour are already spending too much on Britain's welfare state, now is not the time for Andy Burnham to be providing global welfare. There is no reason British taxpayers today should be held financially responsible for things that happened generations before any of us were born. And I have even less patience for political elites in commonwealth countries who don’t know how to make their own citizens prosperous now looking for another opportunity to blame Britain. As Prime Minister, Andy Burnham should be Britain’s greatest defender. Instead, he is writing articles saying we need to confront our history (as if we haven't done enough of that) and considering another formal historical apology. Tony Blair already expressed Britain’s deep sorrow and regret for our role in the slave trade nearly twenty years ago. There is no need to do so again. This is all another navel-gazing distraction. The Commonwealth should be looking forward, not endlessly backwards. That means economic partnerships to make us all richer and deeper military and security cooperation against common threats. If every Commonwealth summit becomes an exercise in presenting Britain with demands for cash then we need to start asking if it is worth the effort.
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we're looking for a postdoc, please get in touch if interested my.corehr.com/pls/uoxrecruit…
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Manav Pathania | @manavpathania.bsky.social retweeted
Excited to share that Spatial Hi-C-RNA is now out in @CellCellPress! It brings the 3D genome into spatial multi-omics by co-mapping chromatin architecture and gene expression in the same tissue section. Congrats to the whole team! cell.com/cell/fulltext/S0092…
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Manav Pathania | @manavpathania.bsky.social retweeted
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science. Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/ nature.com/articles/s41586-0…
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Manav Pathania | @manavpathania.bsky.social retweeted
Out today in @Nature: Daniel Lim, MD, PhD (@danlimlab) and colleagues @UCSF have discovered that genes are controlled not only by DNA sequence and chemical epigenetic marks, but also by where they are located inside the nucleus. 🔗nature.com/articles/s41586-0… danlimlab.ucsf.edu
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Lab summer social a few weeks ago in Oxford, during which we did some punting and played some darts
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Manav Pathania | @manavpathania.bsky.social retweeted
Sometimes I get an anonymous comment on my blog of someone sharing sad truth and it really sucks. One of my hopes for AI in science, and perhaps it's a naïve one, is that cases of sophistry such as described here are exposed more readily and broadly. liorpachter.wordpress.com/20…
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Manav Pathania | @manavpathania.bsky.social retweeted
Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. nature.com/articles/s41586-0… #immunology #cellbiology @immunox @ucsf
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Manav Pathania | @manavpathania.bsky.social retweeted
WOW!! Identification of a neural circuit that enables safe, long-term torpor in mice biorxiv.org/content/10.64898…
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We're looking for a Senior Computational Postdoc to help us analyse our single-cell, spatial and epigenomics data from mouse models and to cross-reference these analyses with data from human tumours. Please get in touch if you're interested! shorturl.at/yXwpC
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We're seeking to fill two roles: a PDRA and an RA. These positions will investigate resistance mechanisms in brain tumour models using in vivo models, spatial omics, CRISPR. Please apply if previous experience aligns! Here is the RA job advertisement: shorturl.at/NVl1V
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We're seeking to fill two roles: a postdoc and a research assistant. Both will focus on resistance mechanisms in brain tumour models using various approaches (in vivo, spatial omics, CRISPR). Please apply if this aligns with your previous experience! shorturl.at/hZ6mG
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Manav Pathania | @manavpathania.bsky.social retweeted
As promised, here's the deep dive on our recent article! Did you know the brain's "sewer drains" (dural sinuses) aren't passive pipes—they're dynamic, ruffling structures that actively guard immunity & regulate pressure? As both a co-author and President & Founder of @neurosimplicity, I am excited to spotlight this groundbreaking discovery from the McGavern lab @NIH_NINDS in @Nature. Our Imaging Suite helped map the amazing cranial & neurovascular connections in unprecedented 3D detail! 🧠🔬 Link: rdcu.be/e4A8i #Neuroimmunology #BrainImmunity
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Manav Pathania | @manavpathania.bsky.social retweeted
Nature research paper: A disease model resource reveals core principles of tissue-specific cancer evolution go.nature.com/4cIrt5i
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Manav Pathania | @manavpathania.bsky.social retweeted
Step 1: Insert bacteria ("Wolbachia") into mosquitoes. Step 2: Release mosquitoes. Step 3: Watch Dengue rates plummet. Phenomenal results from Singapore. Link: tinyurl.com/59c9t67u, by Lim et al.
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Manav Pathania | @manavpathania.bsky.social retweeted
I am excited to share our latest preprint, in which we demonstrate that systemic hypoxia suppresses solid tumor growth. This has been a tremendous collaborative effort in the labs of @IshaHJain and @Genophoria at @GladstoneInst, @ArcInstitute, and @UCSF. biorxiv.org/content/10.64898…
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