@PhdPlatform

Phd platform for the Infection & Immunity PhD program in Utrecht. #IIPhDPlatform

 Utrecht
infectionandimmunity.nl/phd
Joined October 2019
  • Tweets111
  • Following60
  • Followers69
9Media
The IgA response to microbiota in IBD-patients may uncover disease-modifying microorganisms and reveal improved biomarkers of disease progression, concludes @marceldezoete at @UMCUtrecht in a study by Dutch and American investigators in @CellHostMicrobe bit.ly/2NHxbv9
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#OnThisDay, 10 Feb 1917, plant pathologist Johanna Westerdijk becomes the first female professor in the Netherlands when she is appointed at @UniUtrecht #WomenInSTEM #STEMfem #OTD #WaybackWednesday
photo of the faculty, including Johanna Westerdijk

ALT photo of the faculty, including Johanna Westerdijk

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I&I PhD platform retweeted
Julia Drylewicz@JuliaDrylewicz5 Feb 2021
Have a look at our latest #acceptedpaper on #lymphocytes #turnover after #SCT using #deuteriumlabeling and #mathematicalmodeling! @CTI_UMCUtrecht #publication #research #Tcells #Bcells #homeostasis doi.org/10.7554/eLife.59775 @eLife

Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.

elifesciences.org
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I&I PhD platform retweeted
Marcel de Zoete@MarceldeZoete6 Feb 2021
Beautiful work! ⁦@IlievLab⁩ ⁦@CellCellPress⁩ Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies: Cell cell.com/cell/fulltext/S0092…

Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies

Doron et al. present evidence that commensal fungi in the human gut shape antibody responses in the blood to protect the host from systemic lethal fungal infections. The innate immunity regulator...

cell.com
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Our manuscript on the dissemination of E. faecium vanA resistance in Dutch hospitals is now published in Genome Medicine! genomemedicine.biomedcentral… Interested in clonal vs plasmid/transposon dissemination? Check our work! Thanks to @AnitaSchurch for leading this project

Mode and dynamics of vanA-type vancomycin resistance dissemination in Dutch hospitals

Genome Medicine - Enterococcus faecium is a commensal of the gastrointestinal tract of animals and humans but also a causative agent of hospital-acquired infections. Resistance against...

link.springer.com
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UCyTOF.nl launch: Want to apply mass cytometry to your research project? Learn all about it in next week's kick-off seminar in collaboration with Fluidigm (Jan 21, 11:00 CET). @fluidigm @UMCU_CMM @UMCU_Intl @cancercenterumc #cytof
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I&I PhD platform retweeted
Axel Janssen@AxelJans7 Jan 2021
and @wvschaik and me had the opportunity to write a perspective on this. The takeaway message? Be cautious in the use of colistin, for resistance can arise relatively easily. journals.plos.org/plosgeneti…

Harder, better, faster, stronger: Colistin resistance mechanisms in Escherichia coli

journals.plos.org
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I&I PhD platform retweeted
Nina van Sorge@N_van_sorge11 Jan 2021
Cool and important paper out from Malmstrom labs (Lund University) where they elucidated the structural details of StrepA M1 interaction with human IgG. Important for rational M-based vaccine design journals.plos.org/ploscompbi…
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Great to see that mlplasmids sarredondo.shinyapps.io/mlpl… is a useful resource for the community. Will read in detail the manuscript @SamLipworth, congrats! :)
Sam Lipworth@SamLipworth6 Jan 2021
Replying to @SamLipworth
Finally we tried to look at the plasmidome using @Sergi_Arredondo MLPlasmids - we found signal of a diverse plasmidome even in isolates which are closely related at the core genome level. Replicons appeared to be largely genus restricted, though there was some overlap...
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I&I PhD platform retweeted
Axel Janssen@AxelJans4 Jan 2021
Really nice to have this paper out and highlighted by @ASMicrobiology! Want to know about the evolution and impact of colistin resistance in Klebsiella? Read on 👇!
ASM
@ASMicrobiology4 Jan 2021
K. pneumoniae strains can develop colistin resistance through many evolutionary trajectories once exposed to colistin. This includes single nucleotide polymorphisms, insertions and deletions, and the integration of insertion sequence elements. #AACJournal skyw.io/ChbiOn
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Proud to present research by our PhD student Roos Berbers, published @FrontImmunol (frontiersin.org/articles/10.…). Read about how Low IgA Associated With Oropharyngeal Microbiota Changes and Lung Disease in Primary Antibody Deficiency. #immunology #CVID @UMCUtrecht @PhdPlatform
Fig 2. Median relative abundance of top 10 most abundant genera determined by 16S rRNA sequencing of healthy controls (HC, n = 41), CVID +IgA (n = 48), CVID -IgA (n = 33), and XLA (n = 11).

ALT Fig 2. Median relative abundance of top 10 most abundant genera determined by 16S rRNA sequencing of healthy controls (HC, n = 41), CVID +IgA (n = 48), CVID -IgA (n = 33), and XLA (n = 11).

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Please join me in congratulating Suzan Rooijakkers, professor of microbiology @UMCUtrecht, who received today a € 2M Consolidator Grant from @ERC_Research to identify antibodies that use the immune system to fight E. coli infections bit.ly/3m5a88x @MarcBonten #ERCCoG
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Really happy that our article on #longitudinal sequencing of #TCR #repertoires from #scleroderma is now online. Congrats to all the co-authors. @CTI_UMCUtrecht @UMCURRCI @IenI_UMCUtrecht #bioinformatics #rheumatology @airr_community @iRecRepPapers authors.elsevier.com/sd/arti…
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Inhibiting the immune system can impede cancer treatment, how is still largely unclear. In a perspective for @NatRevImmunol @LindeMeyaard introduces a framework to classify different immune receptors which control the response: nature.com/articles/s41577-0… @UMCUtrecht @YaleMed
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New publication from @Vania_LoPresti mdpi.com/2076-393X/8/4/733

Gene Augmentation and Editing to Improve TCR Engineered T Cell Therapy against Solid Tumors

Recent developments in gene engineering technologies have drastically improved the therapeutic treatment options for cancer patients. The use of effective chimeric antigen receptor T (CAR-T) cells...

mdpi.com
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New publication! frontiersin.org/articles/10.…

Frontiers | Early Life Inoculation With Adult-Derived Microbiota Accelerates Maturation of Intest...

Studies in mammals, including chickens, have shown that the development of the immune system is affected by interactions with intestinal microbiota. Early li...

frontiersin.org
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I&I PhD platform retweeted
Nina van Sorge@N_van_sorge21 Nov 2020
Lock down did not just bring down COVID cases but also invasive bacterial infections such as pneumococcal and meningococcal disease around the globe. Beautiful collaboration of the IRIS consortium now in writing on MedRxiv: medrxiv.org/content/10.1101/…

The Invasive Respiratory Infection Surveillance (IRIS) Initiative reveals significant reductions in...

Background Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis are leading causes of invasive diseases including bacteraemic pneumonia and meningitis, and of secondary...

medrxiv.org
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We are looking for a post doc in immunotherapy! academictransfer.com/en/2957…

Post-Doc

Post-Doc on a project on the working mechanism of therapeutic IgA in oncology. Within the Immunotherapy group, you will unravel the modes of action of IgA in vitro and in vivo.

academictransfer.com
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I&I PhD platform retweeted
Marcel de Zoete@MarceldeZoete18 Nov 2020
Very cool story by the Kasper lab! Commensal #microbiota regulate interferon signaling to protect against pathogenic viral infections. ⁦⁦@CellCellPress⁩ cell.com/cell/fulltext/S0092…
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