Philippe DOMENECH (@PhilippeDOMENE2) profile picture

computational neuroscientist and psychiatrist, Full Prof @GhuParis @univ_paris_cite, specialized in #neuromodulation and OCD

Paris
Joined April 2019
🚨 Postdoc Position Available in Electrophysiology & Machine Learning! 🚨 Join our team at the Institute for Neuromodulation (Hôpital St-Anne) in Paris, France. Work on cutting-edge research involving voltammetric recordings in human patients. [1/5] 🧵 #Postdoc #Neuroscience
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🔬 About the Project: Develop and implement innovative electrochemical recording techniques using ML algorithms to decipher the link between neurotransmitter fluctuations and human cognition. [2/5]
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This week, the "computational brain" team (F. Meyniel, @jmourabarbosa, @UNICOG1 ) has moved into its new premises, on the top floor of the Neuromodulation Institute (@FabienVinckier, @GhuParis, @univ_paris_cite), next to Saint-Anne hospital in the center of Paris.
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I heard a rumor there would be champagne at some point. 🥂🥂
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"Optimal level of human intracranial theta activity for behavioral switching in the subthalamo-medio-prefrontal circuit" is out today in @NatureComms ! a cool collaboration with @bastinj_neuro and Mircea Polosan teams. @GhuParis @univ_paris_cite @UNICOG1 tinyurl.com/y282rj3u
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Here, we wanted to better understand the neural mechanisms allowing to reactively switch between rules. So, we recorded LFP from 2 groups of patients performing a rule-switching paradigm: deep brain recordings of the STN in OCD patients and S-EEG from dmPFC of epileptic patients.
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Conférence sur les ECT à l'institut de neuromodulation (17 juin)
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I haven't been very active on this platform in recent months. I have a problem with the current lack of moderation and the promotion of dubious content. I also find it more difficult to have a timeline that allows you to focus on scientific and medical news.
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Despite all this, most of my colleagues continue to use the platform actively. So I'm going to try again ... until an alternative emerges.
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The effect of rNMDA antagonist Ketamine on Human Decision Making: Increased uncertainty and jumping to conclusion ! Computational models, EEG, pharmacological manip, a cool collaboration w @valentinwyart @FabienVinckier @PrGaillard
Inhibiting NMDA receptors derails neural circuit models of decision-making, but does it also mess with actual decisions in the human brain? Our pharmacological study of decision-making under ketamine is out today in @NatureComms. 🎉 Summary thread below: nature.com/articles/s41467-0…
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Decoding Acoustico-Verbal #Hallucinations from multivariate BOLD patterns in Broca’s area. Check our paper in @BiologicalPsyc1 tinyurl.com/a5xpv4vy with @PierreYger, @MHASC1, @FovetThomas et al ! @ParisBrainInst @univ_lille @CHU_Lille @CognitionLille Thread below (1/13):
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(2/13) Innovative therapeutic strategies for drug resistant acoustico-verbal hallucinations (AVH), such as closed loop #neuromodulation or fMRI #neurofeedback, require brain computer interfaces that reliably detect AVH in any patient.
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I've been awarded a young researcher grant from the French National Research Agency @AgenceRecherche to study behavioral adaptation against uncertain and volatile environment. human iEEG recordings, MEG and fun computational models in perspective ! Postdoc positions upcoming !
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Happy to share our last paper with Chen Hu and Mathias Pessiglione "Order matters: How covert value updating during sequential option sampling shapes economic preference" published yesterday in @PLOSCompBiol tinyurl.com/y2nsrfls
Notre revue (en Francais) sur la stimulation du nerf vague dans le traitement de la dépression vient de sortir dans la presse médicale avec Corentin Rabu, Sami Beaumont, Valériane Michel, Suhan Senova, Luc Mallet and Stephane Palfi. sciencedirect.com/science/ar…
Our last review discussing the pros and cons of known DBS targets to treat resistant OCD is finally out ! with my esteemed colleagues Suhan Senova, Luc Mallet and Stephane Palfi. #neuromodulation #DeepBrainStimulation @HuMondor @APHP frontiersin.org/articles/10.…
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If you're interested in #OCD and Deep Brain Stimulation, we just published a case report describing how we treated a severe and treatment-resistant OCD secondary to a NBIA using STN-DBS in Biological Psychiatry. doi.org/10.1016/j.biopsych.2…
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