PlassLab

Last week @Ana_GutiFran attended #RiboRed2026 to present the final results of Stau2 as a regulator of human neurogenesis, a work led by @dedeusan and Akshay Jaya Ganesh. It was a pleasure to be part of @ribored_es conference and meet very talented scientists working on RNA!

Sandra @dedeusan talked about the role of STAU2 in early neurogenesis at the #NeuroSCB2024. Ana @Ana_GutiFran presented the latest results on scRNAseq analysis in AD-derived neurons.

The bioinformaticians of our group had several posters at #ISCO2024: Franz @aerodx5; Akshay and Marcel Schilling enjoyed presenting their work

@miriplass presented the updated analysis of scRNAseq in AD-derived neurons and @dedeusan the most recent results of STAU2 in iPSC-derived neurons

and the lab picture with Akshay, @miriplass @huichen17385141 Marcel and @aerodx5 !

Today we gave two awesome talks at the XI meeting de bioinformatica i genòmica by @aerodx5 and Marcel Schilling.

Happy Lab members after the poster session at the XI jornades de Bioinformàtica i Genòmica. #meeting #bcn #bioinfomeeting

Today Marcel have presented the results of the scRNAseq analysis in hiPSC differentiated to cortical neurons from sporadic Alzheimer's disease patients #regenbell @idibell_cat

We are sharing our latest work at the first Regenbell symposium #regenbell @idibell_cat. Sandra @dedeusan, Akshay, Franz @aerodx5, and Rafa @rtur1412 participated with poster presentations.

Today the first master student of our lab @p_cmrc @idibell_cat Rafa Tur, defended his thesis at @CampusBellvitge! Congratulations for such a great job!

Meet Rafa, our master's student! Collaborating with Sandra, he's studying Staufen2, an RNA-binding protein mainly found in the brain. He is working on neural progenitor cells derived from iPSCs as a model. Their goal? Unraveling Staufen2's role in regulating neurogenesis.

All in all, our comparative analysis shows that Methanol fixation is the best preservation method to perform #scRNAseq in #neural cells, as it does not affect the quality or composition of the samples while introducing low expression biases

Additionally, our results show that DMSO, which is commonly use to cryopreserve samples for #scRNAseq, strongly affects the cell composition of the samples which have reduced amount of neurons!

as well as introduce global changes in the expression of apoptosis and stress markers

Our results show that sample preservation can affect library complexity and the number of genes and UMIs obtained per cell

In this work, led by @Ana_GutiFran & @aerodx5, we studied how common fixation and preservation methods affect the transcriptomic profiles of neural and glial cells