We started with a Pledge to tackle the most challenging drug targets in modern medicine: we are pursuing some of the most sought-after targets in drug discovery
Canton-MA
Joined July 2020
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Pledge Therapeutics retweeted
@JohnCendpts my deepest thoughts & prayers!
Merkel cell #polyomavirus & others including #BKvirus are under appreciated. Given the mention of kidney failure (& possible future transplantation) #BKV is a real threat. Raising awareness is critical. We have developed the first oral, directed, antiviral targeting this family of viruses @PledgeTx @orthogontherapeutics.
Big pharma's top selling medicines are set to lose patent protection, fueling an M&A frenzy.
The first half of this year saw 13 private biotech buyout deals, surpassing the M&A pace set in the last six years.
Will this trend continue?
Sources: BioPharmaDive, AcuityKnowledge
This month, we bid farewell to Dominic Lo and Tran Le. Thank you for your contributions to Pledge, and best of luck in medical & graduate school!
As we say goodbye, we're also thrilled to welcome Dr. Nagraj Mani as our new Senior Director of Virology! #Pledge #TeamGrowth
🎉This week we celebrate the birthday of Rosalind Franklin (25 July 1920): Trailblazing chemist & crystallographic, her X-ray work was vital in unravelling the DNA structure!🧬 #WomenInScience #WomanInCrystallography #leadership
Tremendous news from Orthogon Therapeutics @PledgeTX Antiviral Arm🤩$6M secured for pioneering #BKvirus drug! Our team's dedication and ingenuity bring us closer to delivering the first-ever treatment for #BKvirus! A groundbreaking journey is ahead of us!
businesswire.com/news/home/2…
Once again, our backers have demonstrated their belief in our technology platform and in our mission to develop innovative treatment options for transplant patients businesswire.com/news/home/2…
Farewell, @KULeuven Master Students!🎉After an incredible year of hard work and promising results, we celebrate our student's achievements with a BBQ!🍔😋 Best wishes from all of us at @PledgeTx !
#Brightfuture #DreamBig
Interesting read!#BKV and JC virus create latent infections of kidney cells; immune changes can trigger reactivation and disease. Understanding their behavior is crucial for #smallmolecule interventions.
@PledgeTx #Polyomavirus #SmallMolecule #research
ncbi.nlm.nih.gov/books/NBK65…
Nice article to read on polyoma virus in urine cytology-@mtsiddi Thank you for sharing your beautiful “comet” “ncbi.nlm.nih.gov/books/NBK65…
Monday in our #European HQ--Louanne and Cristina are on fire greasing up their #crystallization plates and prepping for a great round of crystal optimization, looking forward to seeing some nice protein crystals soon!
#Lablife #Science #research #investigation #crystallography
Cryo-EM has achieved atomic resolution and it unlocks new insights and enhances its role in structure-based #drugdesign. At @PledgeTX we employ CryoEM alongside X-ray crystallography, and these advancements are exciting! #Science #DrugDesign
nature.com/articles/s42004-0…
What a great week at #BIO2023 Boston! Our Belgian scientists forged an alliance with a llama unleashing a new therapeutics area at @PledgeTx: Hold onto your lab coats as we introduce nanobodies into our therapeutic modalities! #InnovativeTherapeutics #BioTechDiscoveries #research
Meet us at the Biotechnology Innovation Organization's #BIO2023 conference in Boston! We are excited to connect with fellow pioneers and industry leaders and collaborate to drive innovation in the field of biotechnology.
#BIO2023 #Boston #BiotechInnovation
#standupforscience
Reliable protein models are crucial for #small-molecule #drugdiscovery! @PledgeTx is developing innovative #AI-driven programs to leverage the full potential of prediction data and identify #smallmolecule binders for disease-modifying targets #innovation
wsj.com/articles/meta-ai-unl…
It is #SITC2022 week in Boston! We are growing our #ImmuneOncology #Drugdiscovery pipeline and are
excited to discuss the most recent advances in #immunology #immunotherapy
@PledgeTx #drugdiscovery #biotech #SITC22
@PledgeTx team had an exciting and productive time at #BioEurope2022! Dr @alimunawar, CEO and @Steff_De_Graef wrapped up a successful week in Leipzig discussing #PledgeTX growing pipeline of #Immuneoncology and #Antivirals assets enabled by our #Drugdiscovery platform
Proteins are the origin of most diseases. Scientists at @PledgeTx produce these disease-causing proteins in a high yield and purity and go above and beyond in the number of constructs to identify the one that gives the best-behaved protein! #Drugdiscovery #research #Biotech
Congrats to Stephen Weeks, Director of #StructuralBiology and #Biophysics at @PledgeTx for his new publication at @CommsBio about "Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip" with @KU_Leuven
Crystal structures for leucyl-tRNA synthetase in N. gonorrhoeae reveal multi-domain conformational changes that correlate with a local peptide-plane flip in the active site to compartmentalize catalytic steps.
@PledgeTx @KU_Leuven @Zagreb_Uni
nature.com/articles/s42003-0…
Good review summarizing the #ImmuneOncology #smallmolecule landscape. Our team @PledgeTx is developing the next generation of #ImmuneOncology small molecule drugs to complement existing therapeutic modalities. #Drugdiscovery #Biotech #Research #CancerResearch #Innovation
The expanding role for small
molecules in immuno-oncology go.nature.com/3KkW9JT
A new review covering small molecules targeting cancer metabolism, cytokine/chemokine and innate immune pathways and T cell checkpoints that could be complementary to PD1/PDL1 inhibitors
Insightful article by @PledgeTx CEO, Dr. @alimunawar: "Early-stage biopharma: An opportunity for strategic investment" via @InvestmentWeek
#biotech #biotechjobs #venturecapital #drugdiscovery #earlystagestartups #newbusinessmodels #innovationstrategy investmentweek.co.uk/4054553…
