.9999 fine śūnyatā
Joined July 2008
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What we hear are the echos of thunder, what we see are the lingering flashes of lightning, what we feel coursing through our veins are the winding rivers, and what we speak is the falling rain, infinitely broken and transformed from fractal through fractal for eternities on end.
Darth Manjuśrī retweeted
Each of the 400k particles is a unique, untrained, randomly mutated ~10k param neural net btw 🤗
🔊🦠 Neural-Kimchi-4B 🔊🦠
Darth Manjuśrī retweeted
Guy Debord argued that modern life was increasingly being replaced by representations of itself. In 1994, he died by suicide. David Foster Wallace proposed sincerity as an escape from recursive irony. In 2008, he died by suicide. Mark Fisher wrote about the ghosts of futures that never arrived. In 2017, he died by suicide.
Now it is our turn to solve postmodernism.
Darth Manjuśrī retweeted
Oh, you're worried about a Jewish guy's apocalyptic cult? You're scandalized that they consort with prostitutes? You think their message of compassion for everyone threatens normal bonds of family, community, and nation? Should we throw you a party? Should we invite Pontius Pilate?
Darth Manjuśrī retweeted
Everyone knows the mitochondria is the "powerhouse of the cell." But have you seen how beautifully its movement was captured by Dr. Patrick C. Hickey in this 5th place #SmallWorldInMotion winning video? 🏆 Now you have!
bit.ly/3TgEWKn
Darth Manjuśrī retweeted
Severely autistic, non-verbal 4yo child is given high-dose folate (leucovorin)
- Gains speech in the first week and learns to walk
- Can speak 100 words after 1 year, maintains eye contact and physically active
- When he misses a dose, he relapses
This treatment is insane
Testimonial from a follower
Up to 76% of children with autism may actually have an autoimmune disorder which blocks uptake of folate into the brain, leading to a cerebral deficiency
Autistic children were 19 times more likely to test positive for folate receptor alpha antibodies, which bind with and block folate receptors at the blood-brain-barrier
These children had normal blood results, but very low levels in cerebrospinal fluid
Treatment with a specialized folate supplement, calcium folinate/folinic acid (aka Leucovorin), led to improvement in ~65% of autistic children studied
Standard testing is useless because blood levels of folate show up as normal, but the brain is deficient
Ordinary folate supplements (folic acid, methylfolate) are ineffective because their transport system is blocked
Calcium folinate, on the other hand, works by penetrating the brain via alternative transporters (reduced folate carriers) to effectively restore folate levels
However it must be taken in extremely high doses to achieve this effect. Leading physicians are using approx. 2mg/kg body weight.
Refs:
PMID: 38392599
PMID: 38248763
PMID: 34834493
PMID: 32892962
Darth Manjuśrī retweeted
>looking for a new moral framework
>ask the rationalist if their framework is moral reasoning or pascal’s wager
>he doesn’t understand
>pull out illustrated diagram explaining what is moral reasoning and what is pascal’s wager
>he laughs and says “it’s a good moral framework sir”
>adopt the framework
>it’s pascal’s wager
Darth Manjuśrī retweeted
The printing press led pretty directly to tens of millions of deaths within a generation of its diffusion across Europe. Germany's population dropped 50% by the end of the 30 Years War.
Darth Manjuśrī retweeted
At the next Bay Area House Party:
Oh yeah our startup chemically wireheads bugs. We're producing billions of positive subjective experience-moments and selling them as offsetting credits to regular animal factory farms so they can sell net-positive chicken.
Darth Manjuśrī retweeted
🇸🇦 A Village Built on a Rock in Saudi Arabia.
High in the Asir region, this old stone village sits on a smooth rock more than 700 meters above sea level. It once had around 15 stone houses, an old mosque and a water well, surrounded by agricultural terraces. The village was eventually abandoned in the 1970s.