@RainerNikolay

The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding in Nat. Comms. Read here: https://xitter.cf/t.co/Lm4ibHiuon

Joined July 2022
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  • Following187
  • Followers84
2Media
Rainer Nikolay retweeted
WilsonLab@WilsonLab214 Dec 2025
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination | Nature Methods nature.com/articles/s41592-0…

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental...

Nature Methods - An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted...

nature.com
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Excited to share our new work on the proline-rich antimicrobial peptide Api137, which disrupts large ribosomal subunit assembly and induces RNA misfolding. Big thanks to the Spahn & Hoffmann groups for this amazing collaboration! rdcu.be/d5RsS
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Scientists from @Beck_Laboratory, @MPIbp, @EMBL, including @iskhusainov use #cryoET #teamtomo to compare the response of human gut and laboratory E. coli strains to the antibiotic tetracycline nature.com/articles/s41467-0…
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Read our latest #research on antimicrobial peptides that inhibit the activity of the bacterial ribosome in multiple ways, published in @NatureComms Thx to all co-authors & the members of the Grubmüller, Hoffmann and Spahn groups. rdcu.be/dHxGL nature.com/articles/s41467-0…
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Bacterial growth rate modulation is typically associated with genetic or environmental changes. In this preprint, we show that growth rate in Caulobacter varies between daughter cells in the same environment. Led by (brand-new) Dr. @skye_glenn. #ppGpp biorxiv.org/content/10.1101/…

Coupling of cell growth modulation to asymmetric division and cell cycle regulation in Caulobacter...

In proliferating bacteria, growth rate is often assumed to be similar between daughter cells. However, most of our knowledge of cell growth derives from studies on symmetrically dividing bacteria. In...

biorxiv.org
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Bacterial nucleoid is a riddle wrapped in a mystery inside an enigma @JBacteriology Mini Review by Andrei Kuzminov journals.asm.org/doi/10.1128…

Bacterial nucleoid is a riddle wrapped in a mystery inside an enigma | Journal of Bacteriology

journals.asm.org
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I am very glad to share our paper on 30S turnover!Thank you Helge and Daniel (@WilsonLab2 ) for letting me be part of that fantastic story! I would also use the occasion to thank the collaborators and reviewers for helping us shape this work! nature.com/articles/s41586-0…
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Rainer Nikolay retweeted
Ben Engel@bengeliscious1 Feb 2024
"Integrating cellular electron microscopy with multimodal data to explore biology across space and time"🔬👩‍💻🌌⏳ cell.com/cell/fulltext/S0092… Our new review is online @CellCellPress. Big thanks to our amazing co-authors @computingCaitie @svenklumpe @RommieAmaro @KukulskiWanda @EM_STP
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Rainer Nikolay retweeted
Yasuhiro Arimura@ArmrYshr22 Jan 2024
Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!
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Here is the original article on the “molecular de-extinction” of the antimicrobial peptides doi.org/10.1016/j.chom.2023.…
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Rainer Nikolay retweeted
Deuerling Lab@DeuerlingLab22 Jun 2023
Check out our new study in @sciencemagazine. We show that NAC controls N-terminal methionine excision by MetAP1 in eukaryotes. Our results suggest a broader mechanism for how access of protein biogenesis factors to the translating ribosome is controlled. bit.ly/42SU6nN
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check out our Spotlight Article @TrendsGenetics 🔥 hot 🔥 off the press! teamed up with @OlivierDuss (@EMBLHeidelberg) & @RainerNikolay (@MPI_MolGen) to cover the recent mRNA decoding ribosome smFRET🤝cryoEM story from @TheBlanchardLab open access 👇 authors.elsevier.com/a/1hJjv…
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Rainer Nikolay retweeted
Tarek@tarekh24725 May 2023
Still not where we've been @PhysikFUBerlin but on a good way to get our Krios running after the relocation to #suprafab @FU_Berlin Thanks for your patience to our users, keep fingers 🤞
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Rainer Nikolay retweeted
ISOP@protistologists22 May 2023
Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway | Matus Valach et al. academic.oup.com/nar/advance…
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This is a really cool tool! A generator almost as amazing as nature itself.
Sidney Lisanza@sid_thesci_kid11 May 2023
ARE YOU SICK OF AI?! BECAUSE WE DID IT AGAIN IN AN EVEN MORE OBSCURE SPACE THAN TEXT OR IMAGES. BUCKLE UP BECAUSE THIS WONT MAKE ANY SENSE UNLESS YOU LIKE PROTEINS 💃💃🧬🧵
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Dropping the anchor, how to TRAP a ribosome at the ER membrane! Check out our new study describing a structure of TRAP complex interacting with the ribosome and Sec translocon published today in @NatureSMB nature.com/articles/s41594-0…
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Rainer Nikolay retweeted
ASM
@ASMicrobiology10 May 2023
It's time for #MicrobeoftheMonth! Who am I? 1) I’m a zoonotic pathogen. 2) I am nonmotile. 3) I have caused 3 DNA-verified pandemics during recorded history. Think you know? Leave a guess below!
A blood agar plate with white colonies growing on it.

ALT A blood agar plate with white colonies growing on it.

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Rainer Nikolay retweeted
WilsonLab@WilsonLab28 May 2023
Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-Negative Pathogens - PubMed pubmed.ncbi.nlm.nih.gov/3714…

Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-N...

After the first total synthesis combined with structure revision, we performed thorough in vitro and in vivo profiling of the underexplored tetrapeptide GE81112A. From the determination of the...

pubmed.ncbi.nlm.nih.gov
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Rainer Nikolay retweeted
The Ban Lab@The_Ban_Lab8 May 2023
Wonderful collaboration with @FilipovskaLab reveals secrets of non-canonical translation termination in mitochondria. Structural insights and ribosome profiling explain how mtRF1 recognizes noncanonical stop codons in human mitochondria. @ScienceMagazine science.org/doi/10.1126/scie…
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Rainer Nikolay retweeted
Seydoux Lab@Seydouxlab8 May 2023
Confused about biomolecular condensates? Check out our latest review: genesdev.cshlp.org/content/e… Many thanks to G&D and the anonymous reviewers for an awesome review process!
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