Biophysicist, interested in how interactions of individuals give rise to collective phenomena
Dresden, Sachsen
Joined February 2021
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Roman Renger retweeted
Your molecules are doing something exciting, let's find out what!
We’re visiting labs and conferences across Europe and Boston over the next few weeks. Come meet us 👇
Roman Renger retweeted
🔎 Understanding the molecular mechanism of action of therapeutics, not just the overall impact of their action, is crucial during the drug discovery and development process.
Groves et al. developed a doubly labelled RNA hairpin that acts as a reporter for RNA extension by RdRp when analysed using smFRET.
They used this, alongside FCS, to investigate the mechanism of action of two viral SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors: a nucleotide competitive inhibitor (remdesivir) and a non-nucleotide inhibitor (sumarin).
Overview of this application note (produced in collaboration with the Robb Lab at the University of Warwick):
• smFRET can distinguish non-extended from extended RNA species and the effect of RNA-dependent RNA polymerase inhibitors on this process
• FCS provides further context in the form of identifying RdRp stalling on RNA
• These techniques provide complementary data alongside gel-based assays, distinguishing the mechanisms of action for a nucleotide competitive inhibitor and a non-nucleotide inhibitor
👀 Interested in seeing the data? Access the application note here > excitinginstruments.com/reso…
#smfret #fcs #RNA #proteinrnainteractions
Roman Renger retweeted
🤔 Still wondering how single-molecule FRET works in practice and how it can complement your current techniques?
Our practical handbook explains when - and why - smFRET is the method of choice to use alongside your existing methods by adding a layer of dynamic data that can quantify biomolecular conformations and complex formation.
Download if you want to:
✓ introduce a simple, solution-based method into your existing workflows that rapidly resolves conformational changes at the single molecule level
✓ complement existing static workflows with dynamic data
✓ unlock deeper functional insights and novel biological questions
📖 > excitinginstruments.com/smfr…
#smfret #biophysics #biochemistry #singlemolecul
Really Exciting stuff!🥳
We are launching the next generation of our Exciting single molecule platform at #BPS2026 next week 🇺🇲🇺🇲
Want to see your favorite biomolecules 🧬 in action? This has never been easier, just try it out!
🚀 What do you get when you combine @Craggs_Lab, the @BiophysicalSoc 2026 conference and a very Exciting announcement?
The launch of our brand new instrument... the EI-FLEX Pro!
✅ Automated alignment and focus
✅ Real-time analysis and publication-ready plots
✅ Scale when you're ready - a modular design allows an easy upgrade to 96 or 384-well plates when throughput matters
✅ No darkroom, no optical table, no specialist training
✅ Compact benchtop footprint
This system will transform capabilities in the life sciences and research and discovery pipelines in biopharma, from accelerating drug candidate screening to understanding previously hidden conformations and cryptic binding sites.
Ideal for:
🧬 Validating PROTAC-induced ternary complexes
🔄 Understanding conformational dynamics
🧪 Characterising antibody-target engagement
🧫 Analysing protein aggregation, from the first oligomers
With the quantitative precision of a specialist lab, plus the ease required for modern pharmaceutical R&D.
Meet us at booth 401 at #BPS to see the EI-FLEX Pro in action, including the built-in acquisition and analysis software that makes collecting and interpreting dynamic single-molecule measurements quick and intuitive - whether you're new to the technique or a biophysics expert.
Not heading to BPS this year? No worries - we are happy to offer virtual or in-person demos!
Head to our website to let us know you're interested or comment below.
#singlemolecule #smfret #fcs #biophysics #productlaunch
Roman Renger retweeted
Read our latest blog post about groundbreaking research from the lab of Prof. @Schlierf_Lab ! They use the C-Trap to study how the mechanical stability of bacterial synaptic complexes influences antibiotic resistance.
Learn about this study: lumicks.com/bacterial-integr…
Fantastic opportunity to learn about new techniques that help you to understand chromatin organization and genome integrity on the single molecule level 🧬
Roman Renger retweeted
Kinetic control of mammalian transcription elongation biorxiv.org/content/10.1101/… #biorxiv_molbio
Roman Renger retweeted
🔔Join our webinar on the Structural Maintenance of Chromosomes (SMC) complexes and their critical roles in genome integrity. Learn how cohesin, condensin, and Smc5/6 facilitate chromosome compaction, segregation, and DNA repair with Prof. @AragonLab: bit.ly/3CT4SDP
ALT Register for the webinar "New insights in chromosome organization: Single Molecule Analysis of Eukaryotic SMC Complexes" by Prof. Luis Aragon (Imperial College London, MRC) on Wednesday 26 March 4:OO PM (UTC+1)
Great opportunity to connect with the single molecule community!
Don't miss the chance to register!
📣 2 days left to submit your abstract to join the single-molecule community in Dresden next month.
Connect with pioneers in the field and explore the possibilities of looking at biology molecule by molecule.
Registration is free but seats are limited - secure yours now!
bit.ly/42NVeww
Roman Renger retweeted
Thanks to Ben van Houten for endorsing our LUMICKS C-Trap! ❤️ We're committed to supporting our customers' success! Ben's lab has published several pivotal DNA repair papers since using the C-Trap. Excited for more labs to join us! Check his recent C-Trap publication: bit.ly/40hTRU3
Roman Renger retweeted
We had loads of fun working on this project!
Really excited to share our latest preprint in collaboration with @Sandeep_IMSc's lab. Mycobacterium tuberculosis Nucleoid Associated protein Lsr2 and DNA undergo sequence-dependent co-condensation. Check it out here:
biorxiv.org/content/10.1101/…
Roman Renger retweeted
Ever wondered how scientists braid DNA at the molecular level? Watch our tutorial to see the C-Trap in action and discover the fascinating process of DNA braiding!
Dive into the details and enhance your research skills. Don't forget to like, comment, and share if you like this video!
Movie credit: Ian Hickson lab
#DNABraiding #SingleMolecule #LUMICKS #CTrap
Learn about C-Trap: bit.ly/400r7jD
You like chromatin 🧬, but your current methods kind of don't really give you any useful insights, AND you haven't registered for our webinar with Prof Shixin Liu, yet?
Here is your last chance to discover a new tool!
👉 REGISTER HERE:
web.lumicks.com/20241015-lum…
You finally want to SEE 🔬 what your favorite protein actually does on a DNA molecule 🧬, but all the experiments you run day in, day out only give you vague, somewhat static and indirect hints? 🐌
Try something new!
Register here for our next webinar:
web.lumicks.com/20241015-lum…
Thanks a lot for hosting us, we had a fantastic day at @CssbHamburg!
🔍 Today we had the pleasure of having @LUMICKS_nl at EMBL Hamburg in @CssbHamburg
@JurriensDaphne introduced us to dynamic single-molecule microscopy using DNA - protein interactions along with other applications in phase separation, protein folding and dynamics! 🔬🧬
Roman Renger retweeted
There is little time left to apply for the @ERC-funded PhD and postdoc positions in my new lab in beautiful Regensburg! Check out and RT please :) @jrRNAscientists
euraxess.ec.europa.eu/jobs/2…
Roman Renger retweeted
Academics will write "interestingly" and then impart the driest piece of information you have ever heard in your life
Roman Renger retweeted
A smooth registration followed by the pre-conference workshop by @LUMICKS_nl presented by Daphne Jurriens 📸
🔸 'Single molecule biology: unravelling the mechanisms underlying chromatin organization and transcription' 🔸
#EMBLTranscript
Roman Renger retweeted
Turkey sent a 51 yr old guy with no specialized lenses, eye cover or ear protection and got the silver medal
Roman Renger retweeted
So happy to see this story out!
Dynamic single-molecule and cryo-EM data reveal how the FANCD2-FANCI complex detects damaged DNA sites.
Huge thanks to @palconh, @lapassmore, and @KorakRay for this wonderful collaboration during my postdoc at @RuedaLab @MRC_LMS
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