¡Pasen y lean un nuevo artículo de revisión del lab! Platicamos sobre el uso de LLMs en el diseño de proteínas. :)) 🌟🎊💙
Nueva publicación del Dr. Sergio Romero Romero:
“Descifrando el lenguaje de las proteínas: modelos de lenguaje a gran escala para el diseño y optimización de nuevas macromoléculas” en TIES, Revista de Tecnología e Innovación en Educación Superior: doi.org/10.22201/dgtic.26832…
OMG 🙀
Raygun 1, our model for redesigning proteins the way evolution does, is out today in @Nature. For an arbitrary protein, it can:
- miniaturize (eGFP, shorter than any natural FP)
- magnify (EGF, into a tighter EGFR binder)
- modify (dozens of edits at once-- indels and subs)
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Sergio Romero^2 retweeted
💜 Conoce el Espacio Violeta de la Biblioteca "Armando Gómez Puyou" del IFC.
Un lugar para leer, reflexionar y encontrarte en un ambiente seguro e incluyente. 📚
#IFCUNAM #EspacioVioleta #UNAM
Sergio Romero^2 retweeted
🧪📚 El Dr. @Romeritos (Lab 225 Norte) comparte su más reciente publicación: “Designing de novo TIM barrels” en Biochemical Society Transactions. Léela aquí 👉 portlandpress.com/biochemsoc…
#neuroscience #research #science
Sergio Romero^2 retweeted
Everything you need for AI in Proteins, updated for 2025!
1/🧵
We've expanded our comprehensive AI protein design guide to include all the cutting edge tools on the rise this year. Some highlights:
Sergio Romero^2 retweeted
Excited to announce the release of our open-source protein family language model, ProFam-1, designed to generate functional protein variants and predict fitness using in-context example sequences. 1/n
Sergio Romero^2 retweeted
#Darwin tenía razón. Lamarck… quizá no estaba tan equivocado.
La epigenética muestra que el ambiente puede influir en la herencia sin cambiar el ADN.
@Valdes_Lab_ y @Dr_Alfredo_
bit.ly/4ptHnDM
Sergio Romero^2 retweeted
Check out our latest review, awesome work from Javier Orozco😊, Congratulations 🎊🎉
TH9 cells and interleukin-9 in parasitic infections: Updates, opportun... sciencedirect.com/science/ar…
Proud of my student Diego - now a 2025 Google PhD Fellow! Together we are studying how Protein Large Language Models can design new enzymes.
Congratulations, Diego, well deserved! 💙💜🎉🔬🦠
El IFC felicita a Diego Pérez Villanueva estudiante del Laboratorio 225-Norte, coordinado por el Dr. Sergio Romero Romero, quien fue seleccionado como 2025 Google PhD Fellow, reconocimiento internacional a proyectos de investigación excepcionales.
research.google/progra.../ph…
Pásenle a leer una columna que escribimos junto con @Dr_Alfredo_ sobre Diseño de Proteínas y las oportunidades que tenemos en este campo actualmente. ⭐🧬🔬
Además, la ilustración es por el talentoso de @galen_espinosa
🧪 🧶 Como en un códice tejido con letras químicas, cada diseño proteico guarda una intención, una historia, una posibilidad a futuro.
✏️ @Romeritos y @Dr_Alfredo_
bit.ly/3EUziqg
Sergio Romero^2 retweeted
El próximo martes 6 de mayo, el Instituto rendirá homenaje a nuestra investigadora emérita, la Dra. Herminia Pasantes.
Sergio Romero^2 retweeted
Today we celebrated the International Day of Immunology and the opening of the Genetic Editing and cryopreservation Unit @IFC_UNAM , a project that has been in development for several years and is now finally coming to fruition. Many thanks to everyone who made this happen❤️
🤯🤯
Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics?
@HWaymentSteele and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1!
🧵
Thrilled to share that my former student, Alex Braun, has been awarded the Rainer Rudolph Prize 2024 for his master's thesis on designing artificial enzymes with language models! Immensely proud of him. A toast all the way from Mexico! 🎉👏🌟
Preprint: biorxiv.org/content/10.1101/…
How does collagen fold? Very carefully! (And with some help from electrostatics.) Our latest collaborative study uncovers mechanisms where interchain electrostatic interactions act as molecular clamps to promote proper folding. Check it out! 🎉🌟🧬🧫
nature.com/articles/s41467-0…
Sergio Romero^2 retweeted
Scientists have long known that histones spool DNA and help regulate genes. They may be doing a lot more.
asbmb.org/asbmb-today/scienc…
Sergio Romero^2 retweeted
Thrilled to share our latest publication in Nature: nature.com/articles/s41586-0…. This work reflects a fantastic collaboration—special thanks to David Baker and @TimothyPJenkins. Hoping it sparks attention to this neglected health issue and drives solutions in the years ahead!
