Today we are launching RootPath BinderVerse, a cloud lab for AI-designed binders. Sequence in, binding data out in as few as 3 days, gene synthesis time included! Antibodies and Fab fragments made with CHO cells (TAT from 6 days) and CAR-Ts made with primary T cells (TAT from 10 days) can also be created from your binder sequences and tested. Trustable data at lightning speed -- Learn more at binderverse.rootpath.com

Meet the winners! Based on expert review and social media impact, the five winners of the 1st cycle of Megabase Spark to receive 100 kb of rBlocks™ synthetic DNA are: 🏆 @mcrae_ewan (Houston Methodist) 🏆 Scott Pownall (Open Science Network Society) 🏆 @theicechol (Institute for Medical Engineering and Science, MIT) 🏆 @HansGerstmans (VIB - KU Leuven) 🏆 Hanne Vande Capelle (VIB - KU Leuven) We are inspired by the creativity and ambition of all applicants. Thank you all for submitting your awesome ideas! A huge thank you also goes to our reviewers @ProfTomEllis, @ATinyGreenCell, @timlu and @lecong for lending their expertise and time to evaluate submissions with such rigor. Stay tuned -- cycle 2 of Megabase Spark will open soon!

We are excited to share another #MegabaseSpark submission, titled 'Bio-Based Petrochemicals' from @sean_wirt: "We plan to survey enzymes for activity on non-native substrates, enabling the construction of novel metabolic pathways for bio-based commodity chemicals traditionally derived from petroleum. This research supports the transition to a robust bioeconomy." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

We are excited to share another #MegabaseSpark submission, from @ChrisBatianis: "We wire cell growth to enzyme function: if the enzyme fires, the cell thrives. Thousands of variants turn growth into activity data that train LLM models to design better proteins. Synthesised AI-guided hits push sustainable manufacturing forward." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

We are excited to share another #MegabaseSpark submission, from @nehastar03: "We bioengineer microbial biosynthetic gene clusters (BGCs) to unlock cryptic pathways and discover novel antimicrobial compounds. Using heterologous expression and rational design, we aim to produce potent and structurally diverse bioactive metabolites." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

We are excited to share another #MegabaseSpark submission, from @AmodRBhat: "Tick-borne flaviviruses are stealthy, neglected threats endemic to me but ignored globally. Tired of watching research stall behind biosafety barriers, I intend to engineer "MiniFlaviReps" that are replication competent VLPs but don't require hazmat suits to conduct research.😁" Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

With the deadline approaching, we are excited to share another #MegabaseSpark submission, from @HansGerstmans: "Synthetic refactoring and optimization of a biosynthetic gene cluster encoding a potent anti-breast cancer natural product, to improve potency and production in a breast microbiome-resident bacterium." Like and repost if you like this idea! #SynBio #SyntheticBiology #DNA @KU_Leuven @VIB_microbes

Happy Friday! We got a new #MegabaseSpark submission from @lly_sam1: This research uses synthetic biology to determine if all 20 canonical amino acids are essential for life. By designing and testing proteins with fewer amino acids in bacteria, we aim to uncover fundamental life principles and advance protein design and synthetic biology. #SynBio #SyntheticBiology #DNA Like and repost if you like this idea!

We welcome the first ever #MegabaseSpark submission, from @mcrae_ewan: "We’re building a synthetic library of RNA sequence variants to map how mutations reshape RNA folding and function. By encoding thousands of designed variants in synthetic DNA, we aim to uncover design rules for RNA-based therapeutics and nanostructures." Like and repost if you like this idea! #SynBio #RootPath

Our founder Dr. Xi Chen will be at SynBioBeta 2025 and speaking on the panel “Deconstructing Cellular Diversity: Single‑Cell Sequencing for Drug Discovery & Synthetic Biology,” Thursday, May 8 at 2:30 p.m. Join us to discuss how next-generation gene synthesis technologies and single‑cell genomics can work together to power the next wave of discovery. See you in San Jose!

Did you know? Since launching our gene synthesis service in late 2023, we have shipped over 35,000 constructs to customers in the US, China, Singapore, and the European Union — averaging nearly 700 constructs per week. Thanks to our novel synthesis technology, we routinely deliver orders that are considered too complex to synthesize by conventional gene synthesis providers. You don't have to choose between complexity-tolerance vs low cost. Why not having both 😉 #SynBio #SyntheticBiology #DNA

Did you know? You can save $32K on gene synthesis for a metagenomic mining project that would otherwise cost $63K. In other words, >50% SAVING! Order today: bit.ly/4i4DCk4 #DNA #SynBio

We are proud to launch RootPath Custom Gene Library in the US, slashing gene synthesis cost by more than half, to as low as $0.04/bp. Let RootPath double your screening throughput with the same budget! Learn more from our official announcement: businesswire.com/news/home/2…

We’ll be at #SITC22 this week presenting 3 posters on the discovery of #tumor reactive TCRs in various applications of our proprietary platforms: Pathfinder, Interpreter and DisPATCH. More details are available here: bit.ly/3Uvyhav

We are proud to announce that RootPath’s scientific and technology leaders will present on approaches to #TCell therapy at #SITC22 this November. Learn more here: bit.ly/3rwTKD3 #SITC2022

Our Co-Founder & CEO Xi Chen shared his thoughts with @GenomeWeb: "Key values in biotech in the next 10 years will be created by going back and forth between sequences and functional readouts. What we're going to do is remove the speed bumps in between." bit.ly/38sQG4O