Comparative Genomics #glioma; #aneuploidy #evolution 🧑💻 🧬 | ❤️ 😋 🥘🧑🍳 📷 | @YaleMed | Views = own | ❤️ 🔄 ≠ endorsement.
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Samir Amin retweeted
Children with brain tumors are monitored mostly by MRI. Tumor DNA in blood and CSF (ctDNA) could add a molecular readout but is hard to detect.
New preprint with Phoenix Children's, led by Shea Gallus and @SharvariMankame 🧵
biorxiv.org/content/10.64898…
ALT A brain diagram with ring charts of diagnosis and age group by tumor location for the 28 patients: 4 supratentorial tumors, 23 infratentorial tumors (mostly medulloblastoma and diffuse midline glioma) and 1 spinal tumor.
Samir Amin retweeted
Toward the next generation of CAR T cell therapies for cancer cell.com/cancer-cell/fulltex…
Samir Amin retweeted
🚨 [SCIENCE BREAKTHROUGH]
DREADDs have officially reached human trials.
Chemogenetic neuromodulation aka using viral vectors to install designer receptors in the brain, then activating them with an oral pill, just showed proof-of-concept for refractory epilepsy.
Seizures dropped 92% in 3 patients.
But the real potential is the PLATFORM - I break it down at the end🧵
Samir Amin retweeted
Dreadds work in humans nejm.org/doi/full/10.1056/NE…
The Colour of the Sea by C V Raman 🎂
nature.com/articles/108367a0
Letter @Nature
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Samir Amin retweeted
The theory of evolution lays the foundation of our understanding of why and how cancers change over time and adapt to therapy.
But cancer evolution is a bit special: it is incredibly fast, with multiple routes to adaptation explored at the same time under therapy, and goes beyond genetic alterations, leveraging on heritable (and therefore Darwinian) epigenetic alterations to accelerate evolution.
Important note: whereas genetic alterations are difficult to revert, chromatin changes are, in principle, “editable”. Hence maybe epigenetic drivers of cancer evolution can be "reverted"?
Here’s our take, after more than 10 years working in this field, on the genomic and epigenomic evolution of colorectal cancer. Link below 👇
Via @rikiyatakehi "We think neural network weights will soon be natively optimized by LLMs that deliberately reason about the weights." 🤯
We asked GPT-6 Astra to edit Qwen3.5-0.8B weights to improve math.
It directly changed only 0.016% of weights, fixing 0.8B's reasoning loops & improving math up to 6x and even instruction following 3x, without gradients or training.
We call this Weight-Space Programming: frontier LLMs can now natively read/write neural network weights! 🧵
Blog: rikiyat.github.io/blog/weigh…
Readers added context they thought people might want to know
LLM was given weights explicitly as text in prompt and used code/forward passes (per authors' logs) to ablate Qwen looping direction, a known thinking-mode issue per model card. Primarily fixed repetition in that mode, not general 'natively' improving weights/math.
rikiyat.github.io/blog/weight-sp…
github.com/RikiyaT/lm_und…
huggingface.co/Qwen/Qwen3.5-0…
huggingface.co/RikiyaT/Qwen3.…
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Samir Amin retweeted
Election Tuesday is just two days away. For those eligible to vote in the U.S., please make time to go to the polls to vote (or mail in your ballot if you haven't already). Voting is a great privilege of living in a democracy and how we all make our collective voices heard. 🗳️
🖖
Breaking News: Patrick Stewart, who found acclaim as a Shakespearean actor before making a career pivot that would bring him his greatest fame, has died at 86. He achieved pop-culture stardom with major roles in “Star Trek: The Next Generation” and “X-Men.” nyti.ms/4zc4Ka8
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💎 especially for younglings @RayDalio
A big choice in life is accomplishment versus savoring life.
Savoring life is taking a moment to smell the roses, enjoying a beautiful day, and making sure you have time with the people you love. Then there's the other side, which is accomplishment and impact.
You have to discover for yourself where you are and how you deal with those choices. The key, and the most effective path, is where they align—when you can make your work and your passion one and the same.
#RayDalio #LifePrinciples
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Samir Amin retweeted
Postdoctoral scientist ready to lead your own lab? Applications for our #HannaGray Fellows Program — aka “your launchpad to a faculty career" — open 11/3! Robust funding, a thriving scientific community, & so much more. Register now: bit.ly/4yFH10Z
Samir Amin retweeted
How does the mitotic spindle adapt to genomes that differ in size by more than 10,000-fold? Our new paper in @NatureCellBio reveals a simple scaling law and the physics behind it: chromosome crowding! 🧵
nature.com/articles/s41556-0…
Samir Amin retweeted
I captured this video in my lab to show the power of medicines called T-cell engagers.
Left: T cells move in and out of a cancer tumoroid, largely ignoring it.
Right: Add a T-cell engager, and the T cells attack. Once they recognize their targets, they tear through the tumor.
Samir Amin retweeted
New analysis reveals that development is not a mere readout of a genetic program, but rather a dynamic process in which communities of cells build themselves, and the very landscape they navigate, by mutual negotiation and interaction, into an organism.
quantamagazine.org/how-does-…
Samir Amin retweeted
I had fun chatting with Exa for their inclusion on the 3b1b talent page. It got me thinking about how a lot of the goals for better search end up aligning with goals of better credit assignment/attribution.
We sat down with @3blue1brown to discuss our research vision of "Attention over all the world's information."
Plus why knowledge should not live in model weights, the compression trick behind cheaper retrieval, and why we hire through work trials.
1:20 – What is “attention over everything”?
4:46 – A knowledge graph of the whole web
11:32 – How do you evaluate search for AI agents?
15:13 – Why not put everything in the weights?
22:55 – Why Exa hires through work trials
25:15 – The compression trick behind cheaper retrieval
27:40 – Dealing with misinformation
Samir Amin retweeted
SAVE THE DATE! 10/20/26 Genetics Seminar Speaker Dr. Jonathan Pritchard, PhD, Stanford University, presents: "Trait Causal Models: Harnessing GWAS and perturbations to understand human biology."
Link below...
medicine.yale.edu/event/gens…
ALT Headshot of Genetics Seminar Speaker Dr. Jonathan Pritchard, PhD.