@SBenzekry

Mechanistic learning for clinical oncology. Head of the Inria-Inserm team COMPO (COMPutational pharmacology and clinical Oncology)

 Marseille, France
www-sop.inria.fr/members/Sebastien.Benzekry/index.html
Joined June 2011
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  • Followers454
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📣 New paper out! "Predicting Survival in Patients with Advanced NSCLC Treated with Atezolizumab Using Pre- and on-Treatment Prognostic Biomarkers" kinetics-Machine Learning outperformed SOTA for: 👩‍🔬 Prediction of individual survival 💊 Prediction of phase 3 trial success
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Want to know what we do at Inria - Inserm COMPO ? Have a look at this blog post where I explain success stories of hashtag#mechanistic hashtag#learning to improve clinical oncology. mathematical-oncology.org/bl…
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#ICYMI: A Senescence-Mimicking (Senomimetic) VEGFR TKI Side Effect Primes Tumor Immune Responses via IFN/STING Signaling. bit.ly/4djIG1u @eboslab @Sbenzekry @ACS_Research @GeneticsRoswell @RoswellPark
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Exciting new postdoc position at @Inria – @Inserm COMPO in sunny Marseille combining single-cell genomics and pharmacodynamics to optimize treatment combinations against pediatric cancer (rhabdomyosarcoma). jobs.inria.fr/public/classic…
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A highly inter-disciplinary project led by the highly talented biologist Dr Laura Broutier @crcl and in collaboration with the fantastic pharmacologist Dr Eddy Pasquier @translateitcrcm @crcm_marseille #SingleCell #heterogeneity #PKPD #computationalOncology #pediatricCancer
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Sébastien Benzekry retweeted
Sandy Anderson@ara_anderson4 Jul 2024
Looking forward to the minisymposium organised by Eunjung Kim on Mathematical model guided cancer treatment. 1st up is friend @SBenzekry presenting, Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer #SMB2025 #KSMB
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Extremely happy to share our latest paper with @EbosLab @RoswellPark in @PLOSCompBiol : Machine-learning and mechanistic modeling of metastatic breast cancer after neoadjuvant treatment. #mechanisticLearning journals.plos.org/ploscompbi…

Machine-learning and mechanistic modeling of metastatic breast cancer after neoadjuvant treatment

Author summary Using simulations from a mechanistic mathematical model compared with preclinical data from surgical metastasis models, we found that anti-tumor effects of neoadjuvant receptor...

journals.plos.org
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🖥️gitlab.inria.fr/benzekry/met…

BENZEKRY Sebastien / metamats.burden.treatment · GitLab

Gitlab at Inria

gitlab.inria.fr
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@Inria @translateitcrcm @Inserm @crcm_marseille
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Glad to have contributed to the analysis of the massive research effort and data generated by @EbosLab just published in @MCT_AACR. The results show how #VEGFR #TKI-induced #senescence-mimicking effects modulate #tumor-#immune interactions and response to immunotherapy.
John Ebos@EbosLab1 May 2024
Happy to share our new paper: A senescence-mimicking (senomimetic) VEGFR TKI side-effect primes tumor immune responses via IFN/STING signaling. Amazing effort by an excellent group! @MCT_AACR @ACS_Research @GeneticsRoswell @RoswellPark aacrjournals.org/mct/article…
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Sébastien Benzekry retweeted
John Ebos@EbosLab1 May 2024
Happy to share our new paper: A senescence-mimicking (senomimetic) VEGFR TKI side-effect primes tumor immune responses via IFN/STING signaling. Amazing effort by an excellent group! @MCT_AACR @ACS_Research @GeneticsRoswell @RoswellPark aacrjournals.org/mct/article…
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Sébastien Benzekry retweeted
Andre@venturini_andre1 May 2024
Replying to @dumebarbolosi
@dumebarbolosi @barlesi @SBenzekry @jo_ciccolini @IsulaCorsica @UnivCorse @univamu @aphm_actu @crcm_marseille #thepioneerproject
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New preprint out! Computational modeling approaches for circulating cell-free DNA in oncology first-authored by the @CancerImmunoAMU funded talented PhD student @Linh_Fe2A co-supervised by myself and Pr Salas #computational #oncology #cfDNA hal.science/CRCM/hal-0448168…
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When it comes to #preclinical models of #metastasis, @EbosLab is the best-in-class. And now we have together just publicly released the largest #dataset of metastatic development. 251 mice implanted either untreated or pre-surgically treated. zenodo.org/records/10607753

Pre- and post-surgical monitoring of experimental primary tumor growth and metastasis under...

Summary This comprehensive dataset contains pre-surgical primary tumor volume measurements and pre- and post-surgical records of metastatic burden in 251 mice implanted with human breast cancer cells...

zenodo.org
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Publication soon to be published with the #mathonco modeling of this uniquely rich data, where we show that not only math modeling can describe but it can also test biological hypotheses and bring valuable biological insight
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🗓 Join us on Saturday, the 10th, at 9 am for Session 5 on "Tools for Predictive Oncology"! Engage with our international speakers @SBenzekry, Denis Lacombe, Annalen Bleckmann, & Maddalena Centani through captivating talks. Register ➡ swll.to/b9XL9j #Oncology @EORTC
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Our latest work is out! 📚🧠 It explores the response of brain metastases to radiation and reveals a game-changer for response assessment doi.org/10.1093/noajnl/vdad1… @molab_uclm @EditorNeuro @MetastasisRS @AranaE_MD
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