Understanding the molecular and genetic mechanisms of a variety of developmental disorders and paediatric diseases to improve global child health outcomes.
Toronto, Canada
Joined February 2021
- Tweets95
- Following121
- Followers283
- Likes198
Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models. @cirunalab @SickKidsNews
rdcu.be/eIT2f
scienmag.com/oxidative-stres…
@SickKidsNews @CIHR_IRSC @NatureComms @sickkids @UofT @mogen
Great work being done by postdocs in @yunli lab in the @SKDevStemCell program at SickKids.
youtube.com/watch?v=fODijlKw…
Developmental, Stem Cell & Cancer Biology retweeted
Very pleased to post this new study from my group led by Kinjal Desai, targeting a rare cell fate OLIG2-mediated transition in the medullo hierarchy with CT-179. Preventing stem cell activation!#naturecomm
can01.safelinks.protection.o…
Developmental, Stem Cell & Cancer Biology retweeted
Great job @FabianDoktor and the @Zani_Lab! Another important paper highlighting the effects of #EVs on fetal hypoplastic lungs 🫁! @SKDevStemCell @Me4Ped @cdhintl @CDHUK_CHARITY
Delighted to share our latest research on #EV based therapies for fetal pulmonary hypoplasia secondary to oligohydramnios published now at the Journal of Controlled Release! kwnsfk27.r.eu-west-1.awstrac…
@sickkids @CIHR_IRSC @dfg_public @EupsaSurgeons @APSASurgeons @JCRnEDITORS
Developmental, Stem Cell & Cancer Biology retweeted
Why are so many inherited traits not explained by genome sequence variation? In my PhD work with @wbderry we describe a new mechanism of inheritance in animals that may account for this ‘missing heritability' 🧵nature.com/articles/s41556-0…
Ulcers increase the risk of gastric cancer, but the mechanisms underlying this association remain unclear. The Kim and Guo labs demonstrate that YAP signaling promotes both gastric regeneration and metaplasia, a precancerous lesion. cell.com/cell-reports/fullte…
lab.research.sickkids.ca/kim…
Developmental, Stem Cell & Cancer Biology retweeted
Weifan's paper has been featured on the cover of Nature Cancer @NatureCancer
Developmental, Stem Cell & Cancer Biology retweeted
A newly discovered protein-protein interaction has sparked the development of a novel treatment for #glioblastoma 🧠
Published in @NatureCancer, the #SKResearch team is now working to advance this therapy into clinical trials as soon as possible.
Read ➡️ bit.ly/469uANh
Developmental, Stem Cell & Cancer Biology retweeted
Today, we report in @NatureCancer a new approach to treat glioblastoma (GBM). First and foremost, this is the work of recently graduated Dr. Weifan Dong, who has championed this study for the past 7 years with ingenuity and perseverance. @SickKidsNews @SKDevStemCell @MoGen_Grad
Great work!! Congratulations!
Excited to share our paper "Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes" science.org/doi/10.1126/scia…, led by our extremely talented postdoctoral fellow Xian Wang.
Kim lab.research.sickkids.ca/kim… and Wilson wilsonlab.org labs at SickKids have defined the epigenetic regulation of mesenchymal niche signals in stomach and intestinal development.
nature.com/articles/s41467-0…
Developmental, Stem Cell & Cancer Biology retweeted
First 2023 issue is out! cell.com/neuron/current
Cover art by Siqi Ou illustrates Chen & coll. findings on mechanosensitive brain tumor cells that form the blood-tumor barrier to mask chemosensitivity
Paper: cell.com/neuron/fulltext/S08…
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Dr. Tae-Hee Kim's lab lab.research.sickkids.ca/kim… identifies key immune and microbial factors in the gut that influence newborn stem cell development, with implications for the treatment of necrotizing enterocolitis.
sickkids.ca/en/news/archive/…
Congratulations Dr. Vijay Ramaswamy @vijayvijay1979 for Canada Research Chair award (Tier II) to identify weaknesses in medulloblastoma and ependymoma, the first and third most common paediatric brain cancers.
lab.research.sickkids.ca/ram…
@SKDevStemCell @SickKidsCancer @sickkids
Great work from @XiHuang18 lab.
lab.research.sickkids.ca/hua…
@SRC_CRS @CIHR_IRSC @SickKidsCancer @braincancercan @NoBrainCancer
A SickKids team led by Dr. Xi Huang has uncovered the mechanics of the blood-tumour barrier, laying the foundation for more effectively treating medulloblastoma, the most common malignant paediatric brain tumour.
Read more ➡️ bit.ly/3fwHHmK #SKResearch
Congratulations!!
🥳YAYY!!🥳Incredibly happy to share our work on the Human origins of Group 4 Medulloblastoma published today in @Nature. Massive collaborative effort to nail down a cell type found only in developing human brains as the cell of origin of these tumors
nature.com/articles/s41586-0…
Congratulations to Dr. Tae-Hee Kim @SKDevStemCell lab.research.sickkids.ca/kim… for securing the @CIHR_IRSC operating grant titled: Mechanisms of intercellular communications in gut homeostasis and disease.
@SickKidsNews @sickkids @CIHR_ICR
Developmental, Stem Cell & Cancer Biology retweeted
Dr. Xian Wang is one of our Brain Tumour Research Fellowship recipient. We are so grateful for is amazing work and how he is helping advance brain tumour research. Learn more about his research project: bit.ly/3RXf94f
@XiHuang18 @SKDevStemCell @uoftmie
Microrobotic Swarms for Intracellular
Measurement with Enhanced Signal-to-Noise
Ratio - recent work of Dr. Xian Wang published in ACSNano from
@XiHuang18 lab @SKDevStemCell lab.research.sickkids.ca/hua… and Dr. Yu Sun's lab mie.utoronto.ca/faculty_staf……
@uoftmie
Microrobotic Swarms for Intracellular
Measurement with Enhanced Signal-to-Noise
Ratio - recent work of Dr. Xian Wang published in ACSNano from
@XiHuang18 lab @SKDevStemCell lab.research.sickkids.ca/hua… and Dr. Yu Sun's lab mie.utoronto.ca/faculty_staf……
@uoftmie
They have developed a magnetic robotic system to control fluorescent dye-coated nanoparticles to form a swarm for intracellular ionic measurement. Their system displays a signal-to-noise ratio ten times higher than traditional ionic dyes.
Using this approach, they have discovered mechanical force-activated calcium dynamics at nanoscale resolution within single brain tumour cells.
pubs.acs.org/action/showCitF…
@SKDevStemCell @SickKidsNews @CIHR_ICR @BrainTumourFdn @acsnano @SRC_CRS @theABTA @sickkids @SickKidsCancer
