Single-cell Profiling and Engineering Center, Beckman Institute
Pasadena, CA
Joined September 2018
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Congrats to Xiaoqiao Chen for her first first-author publication today in Nature Computational Science. Xiaoqiao's method assembles small lists of highly informative genes using an iterative SVM method. She uses a clever 'active' strategy to only prioritize cells and genes that
maximally informative. Her method is very resource efficient, allowing her to compute >1M cells on a fairly typical AWS instance. nature.com/articles/s43588-0…
Really excited about this work from @Allan_HPool, showing how missing genes due to intronic reads and poor 3' annotation can be recovered with optimized reference transcriptomes.
First Pool Lab pre-print: bit.ly/3yoewcy. We resolve a major pain with 3’ single-cell RNA-sequencing (10x Genomics etc.) – missing gene expression data from thousands of genes. This stems from suboptimal reference transcriptomes and can easily be recovered. T below: 1/12
We are hiring!! Looking to hire a research technician to execute a focused project on exploring human cell surface proteins on the human immune system using single-cell RNA-seq. phf.tbe.taleo.net/phf03/ats/…
Congrats @Pselaphinae and @AdrianBrueckner!! Nice to see this beautiful story finally in print!
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Whoohoo!! Congrats @Wonderstrucksci
It's so fun to let loose and get creative with @mitchguttman @sofiquinodoz. We developed a great idea and I'm pleased to see my art on the cover of @CellCellPress today. Plus there's more fantastic work from Guttman Lab @Caltech inside.
Congrats to @dibidave @AltermattMi and @cosmotat for their new paper on determining AAV cell type specificity using single-cell RNA seq!
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Really cool spatial-sequencing method from UCSF. Have been talking with Eric about this for quite some time... Cool to see it finally in print! XYZeq: Spatially resolved single-cell RNA sequencing science.org/doi/10.1126/scia…
Congrats to all of the authors for a beautiful new paper! We were happy to support the single-cell profiling experiments in this very intriguing EPES synthetic embryo system.
My heartfelt thanks for this work to my institution @Caltech @PDN_Cambridge @Cambridge_Uni My wonderful lab @MZG_Lab and especially @BernaSozen_ , my first Caltech PhD student Victoria Jorgensen, my PhD student in Cambridge @BailWeatherbee, and wonderful @sisichen & @zhumeng123
Super cool work from @BEuplotes and @WallaceUcsf !
Nice article by @mjflepage in @newscientist about the work or @BEuplotes on how the walking gait of single cell Euplotes may be controlled by a microtubule based computer. I feel this piece poses the big question and sums up the key points in a super clear way! @I2CELL
Congrats David and Tatyana! @dibidave @cosmotat
The preprint for my main PhD project is out! biorxiv.org/content/10.1101/…. We characterize the cell types in the brain (cortex) that get targeted by different AAV gene therapy vehicles (in mice ;) )
SPEC Caltech retweeted
We are proud to recognize professors Dianne Newman and Jonas Peters for their election to @americanacad.
This election is a recognition of "extraordinary people who help solve the world’s most urgent challenges ... and contribute to the common good..." 👏
ALT Dianne Newman, pictured in her laboratory
ALT Jonas Peters, pictured in a green landscape with mountains in the distance
SPEC Caltech retweeted
Really enjoyed the talk of Sisi Chen at #RNGS21!
The team combines popAlign and multiseq to unravel distinct drug responses in immune cells, leading to exiting yet sometimes unexpected discoveries🤯
😯I will watch out with artificial sweeteners...
Well-deserved!
Congratulations to Rob Phillips, who was recently awarded Caltech's top prize for excellence in teaching. One nominator cited Phillips's "remarkable ability to make scientific discovery feel special." ow.ly/S8aB50DOqys
SPEC Caltech retweeted
Engineers place molecule-scale devices in precise orientation @Caltech @sciencemagazine phys.org/news/2021-02-molecu…
SPEC Caltech retweeted
Single cell research will be a major focus during #RNGS21, presented to you by some of the leading figures in this field. Check out the full program: bit.ly/3pudEuS
⏰registration deadline: 26 Feb #transcriptomics #genomics #proteomics #multiomics #singlecell #sequencing
SPEC Caltech retweeted
So thrillled that our work received the SLAS2021 Innovation award!!! Truly a team effort @SPEC_Caltech with
@TamiKhazaei, @cmcginnisUCSF, @ZevGartner, Eric Chow at @CAT_UCSF, Matt Thomson, Jeff Park, and Tiffany Tsou (now grad student at NYU)
We are pleased to announce Siyu Chen, Ph.D. (@Caltech) as the #SLAS2021 Innovation Award winner, sponsored by @BCILifeSciences. Chen won for her presentation, Defining the Breadth and Specificity of Drug Response in Heterogeneous Immune Cell Populations. 1/2
Congrats to @cosmotat @dibidave, Jeff Park and Matt Thomson for their paper on single-cell profiling of capillary blood!
nature.com/articles/s41598-0…
