PostDoc @Cedars Sinai LA USA, PhD-ILBS, HBRS Germany, Neurohepatology, LiverBiology, Molecular Medicine, Neurology, Transgenics, Tissueclearing, Proteomics
California, USA
Joined February 2013
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Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
UBE2N deficiency contributes to MASH development via p62-regulated mitophagy and PANoptosis dlvr.it/TVKKMF
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
The MOSAIC reconfigurable microscope by @Eric_Betzig et al is finally out!
MOSAIC integrates multiple advanced imaging techniques including light-sheet, label-free, super-resolution, and multi-photon, all equipped with adaptive optics:
biorxiv.org/content/10.1101/…
Nice work, Congratulations to the Whole team 👏👏👏
Introducing our single-cell DVP framework combining strategic cell selection with protein gradient mapping algorithms. Analyzing hepatocyte proteomes across 18 human livers, revealing cross-species differences, and mapping disruptions in liver fibrosis.
biorxiv.org/content/10.1101/…
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Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
Introducing #AlphaQuant: Our tree-based proteomics quantification detects up to 50X more protein regulation, scores accuracy, and clusters peptides to infer regulated proteoforms.
github.com/MannLabs/alphaqua…
biorxiv.org/content/10.1101/…
A thread by @ConstantinAmmar explains below:
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
Let’s get fitter and healthier.
Let’s fight obesity and reduce edible oil consumption by 10%.
During today’s #MannKiBaat, we had @Neeraj_chopra1, @nikhat_zareen and Dr. Devi Shetty share their views on this issue that is increasingly impacting our youth.
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
Thrilled to share our latest work published in @NatureGenet today: Plasma proteome variation and its genetic determinants in children and adolescents. 🩸#PediatricProteomics #PlasmaProteomics #pQTL
nature.com/articles/s41588-0…
🧵A thread by @hustniu explains below ⬇️
The inspiring Futuristic Research from Sir Ali's Lab. Game changing Science out @NatureBiotech congratulations @erturklab
See our recent @NatureBiotech study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 nature.com/articles/s41587-0…
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Always the Great and futuristic science from your Lab Sir.
Congratulations to the fantastic Team✌💐
Imagine seeing a disease's impact on every cell in the body. Now, you can!
We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. MouseMapper showed obesity-induced changes in facial nerves & body-wide inflammation 👉🏼🧵biorxiv.org/content/10.1101/…
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Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
Imagine seeing a disease's impact on every cell in the body. Now, you can!
We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. MouseMapper showed obesity-induced changes in facial nerves & body-wide inflammation 👉🏼🧵biorxiv.org/content/10.1101/…
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
It's always good to remember that 60% of us who had COVID still might have viral protein accumulation in the skull and brain, which can have implications for #LongCOVID. The image and video below are from @erturklab's work. biorxiv.org/content/10.1101/…
The government/media likes to describe Long Covid using vague terms, like continuing symptoms, or it's ill defined. We need more research, etc. We actually know quite a bit. They are avoiding accountability for their hopium. 😣h/t @DurianLiftOff
ALT Two mice. One with influenza showing virus around the lungs. Another SARS-CoV-2 Alpha Variant where the mouse has virus everywhere including the lungs.
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
Online now!
Unveiling the cancer risk nexus of the steatotic liver.
A review by @SekiEki & Jieun Kim in @Trends_Endo_Met #ASCO24 hubs.li/Q02yvFcf0
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
Making India proud !!!Director @drshivsarin received the prestigious American Gastroenterological association Recognition award as Distinguished Clinician Award in Academic Practice @DDWMeeting 2024,@AmerGastroAssn First Indian to receive the honour.
Today I have Successfully defended my PhD thesis, Officially Dr. now.
I am thankful to My Supervisor, Prof Shiv K Sarin @drshivsarin, Co-Supervisiors @savykaur3 and other colleagues and Collaborators (Dr Csaba, Sweden) and Prof Ali for guidance and accurate protocols @erturklab
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
Congratulations to the 2023 medicine laureates!
Watch the very moment Katalin Karikó and Drew Weissman received their Nobel Prize diplomas and medals during the 2023 Nobel Prize award ceremony.
#NobelPrize
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
Hey folks! These are unauthorized snapshots of @kkariko and Drew Weissman receiving the @NobelPrize. And @perlmannlab congratulating them! Hopefully I was discreet.
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
It took 4+ years to build this 3D map of the developing human head, the most complex part of our body sciencedirect.com/science/ar…
Tissue clearing #Lightsheet #VirtualReality #3D models & More! Congrats to Raphael Blain, E. Shotar G. Couly @Yorick_Gitton et al. video summary 🔊
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2023 #NobelPrize in Chemistry to Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov “for the discovery and synthesis of quantum dots.”
Sadam H Bhat🇧🇪🇺🇲🇮🇳🇹🇷🇸🇦🇬🇧🇨🇴🇺🇦 🇸🇪 retweeted
The discoveries by Katalin Karikó and Drew Weissman – awarded the 2023 #NobelPrize in Physiology or Medicine – were critical for developing effective mRNA vaccines against COVID-19 during the pandemic that began in early 2020.
Through their groundbreaking findings, this year’s laureates have fundamentally changed our understanding of how mRNA interacts with our immune system. They have contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times.
ALT A blue background with COVID-19 virus and a yellow strand of modified mRNA. Also shown is the chemical structure of pseudouridine, an RNA base that was important in the prize-awarded discovery. The graphic represents the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karinkó and Drew Weissman who received the Nobel Prize in Physiology or Medicine for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.