@SamElOsta1

Sam is an epigeneticist dedicated to understanding health and disease. Clinical importance over statistical significance. Baker Heart and Diabetes Institute.

 Melbourne, Vic
baker.edu.au/research/laboratories/human-epigenetics
Joined April 2020
  • Tweets2.3K
  • Following1.9K
  • Followers787
103Media
Grateful for all the recent interest by clinicians and scientists in our Diabetes (ADA) paper: DNA methylation biomarkers in cord blood predict future metabolic risk with 79% greater accuracy than traditional factors. A window into lifelong health. Read: doi.org/10.2337/db25-0105
🤖 Made with AI
3
283
Prof Sam El-Osta retweeted
Katja Kobow@KatjaKobowJun 9
🚨New preprint out: A novel diagnostic intracranial EEG biomarker in MOGHE medrxiv.org/content/10.64898…. Great multi-center interdisciplinary study with clinical impact. #epilepsy @IlaeWeb

A novel diagnostic intracranial EEG biomarker in MOGHE

Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) is a recently recognized cause of drug-resistant focal epilepsy. It is often MRI-negative or shows...

medrxiv.org
1
1
1
3
572
Prof Sam El-Osta retweeted
nature
@NatureOct 22
Obituary: Robert Williamson (1938-2026) geneticist who mapped genes for muscular dystrophy and cystic fibrosis go.nature.com/4yCva3T

Robert Williamson obituary: geneticist who mapped genes for muscular dystrophy and cystic fibrosis

Nature - Researcher and policy adviser who championed tests and treatments for genetic diseases.

nature.com
5
45
2
177
27,478
Prof Sam El-Osta retweeted
nature
@NatureOct 12
How much do PhD students earn? The first comprehensive overview of PhD income shows vast imbalances across much of Europe Read the full story: nature.com/articles/d41586-0…
47
375
74
1,343
239,061
A long time coming - our DKD epigenetics study is now Online Ahead of Print in Diabetes. Blood DNA methylation score linked to renal epigenomic change. Great collaboration with Peter Rossing & Denmark, and fitting to share from the BT1D CRC meeting. lnkd.in/gzZXyRZn
1
4
130
Great to reconnect with friends, Lorenzo Piemonti in Philadelphia with Keith Al-Hasani at #BreakthroughT1D. The challenge ahead is increasingly clear: restore β-cell function, protect it from immune destruction, and translate both into durable insulin independence.
2
6
298
Looking forward to the Vertex session at #BT1D on the evolving landscape of #T1D care. The field is moving beyond better insulin replacement toward disease modification, β-cell preservation, cell replacement and immune protection. Question - how far can we change its biology?
70
Day 2 at #BT1D in Philadelphia with friends Tom Loudovaris, Keith Al-Hasani & Tom Kay. Great conversations on the future of #T1D research, β-cell biology, regeneration, immune protection and translation. The goal is bigger than better management: change the biology of T1D.
1
6
207
Breakthrough T1D Congress, Philadelphia. October 9-11. Shaping the future of T1D.
1
3
129
From N-of-1 therapy to health-system implementation nature.com/articles/s41573-0… rdcu.be/czXCkzMfDeda This Correspondence article highlights the need for transparent frameworks to prioritize the patients and targets for which n-of-1 therapies are developed
1
7
2
19
2,444
Prof Sam El-Osta retweeted
Prof. Nikolai Slavov
@slavov_nSep 30
bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.
19
175
12
890
39,796
Prof Sam El-Osta retweeted
nature
@NatureSep 28
Hearts from young donors age rapidly in the bodies of older recipients, and older hearts are rejuvenated inside young people go.nature.com/4rzzsHf

Old hearts age backwards: transplanted organs adjust to host’s biological age

Nature - Tracking the biological age of grafted organs suggests that donor pools could be expanded to boost organ availability.

nature.com
50
680
131
2,126
317,577
Prof Sam El-Osta retweeted
Ming "Tommy" Tang@tangming2005Sep 21
The DNMT1 CXXC domain senses CpG islands for DNA methylation inhibition nature.com/articles/s41467-0…
3
1
27
2,954
Prof Sam El-Osta retweeted
The Lancet
@TheLancetSep 18
What makes a meta-analysis believable? In our latest issue, a new Viewpoint outlines how to identify meta-analyses that merit clinical confidence. Explore the full issue: spkl.io/60197rxth
Cover of The Lancet September 19, 2026 issue. Quote reads: Meta-analyses are not definitive truths, but rather structured efforts to interpret incomplete, evolving, and sometimes inconsistent evidence.

ALT Cover of The Lancet September 19, 2026 issue. Quote reads: Meta-analyses are not definitive truths, but rather structured efforts to interpret incomplete, evolving, and sometimes inconsistent evidence.

7
166
5
410
39,491
Prof Sam El-Osta retweeted
BioTender
@Junioryu136689Sep 17
Cell just dropped a full Focus Issue on AI in Biology. Virtual cells. World models. 500M+ cell repositories. 100M-scale perturbation atlases. Aging benchmarks. 4D mitochondria. Multimodal cancer prediction. Here are the 13 pieces worth reading 🧵
🤖 Made with AI
17
75
2
354
17,635
Prof Sam El-Osta retweeted
Di Jiang@dijiang319Sep 17
Today @ScienceMagazine A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas | Science science.org/doi/10.1126/scie…
1
27
159
16,328
Prof Sam El-Osta retweeted
ASN Publications
@asnpublicationsSep 17
The latest ASN Kidney Health Guidance on the Cardiovascular-Kidney-Metabolic Syndrome, in #ASNJASN, addresses diagnosis and treatment of the CKM syndrome most relevant to the nephrology team and covers issues of special consideration for patients with kidney disease. JASN.org/KHGcKm
2
59
2
144
6,960
New online! Gene regulatory mechanisms downstream of DNA methylation dlvr.it/TVWm8B
55
1
203
12,923
SixPack-AbScan is a free web server that pre-screens epitope-mapped antibodies for cross-reactivity across species by exact-matching epitopes against proteomes or six-frame–translated genomes. biorxiv.org/content/10.64898…

SixPack-AbScan: a web server to discover cross-reactivity of antibodies across species

Availability of commercial antibodies for immunochemistry is typically limited to major model species. Researchers working on non-model organisms therefore often need either to generate novel...

biorxiv.org
5
13
1,618
Prof Sam El-Osta retweeted
Molecular Cell@MolecularCellSep 15
Online Now: 5-Azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia dlvr.it/TVV8jR
11
34
5,229
Prof Sam El-Osta retweeted
Science Magazine
@ScienceMagazineAug 26
"As I sat at my desk wrestling with the grant proposal I was coordinating, I could feel my eyes glaze over. I’d spent all afternoon figuring out how to keep dozens of consortium partners happy, and I was now deep in the thankless task of cutting budgets and moving numbers from one column to another. But just then an unlikely lab member offered a reprieve: my dog, Zazil." #InternationalDogDay scim.ag/4eP9pHg
An illustration of three people and a dog, with text: What my dog taught me about leading a lab

ALT An illustration of three people and a dog, with text: What my dog taught me about leading a lab

5
21
3
99
47,452
Load more