@SchertzerLab

Immunometabolism research: Diet, microbes, drugs and hormones

 McMaster University
Joined December 2012
  • Tweets2.2K
  • Following746
  • Followers1.5K
24Media
Jonathan Schertzer (SchertzerLab) retweeted
Jens Lund@jens_lundOct 21
Did the lactate metabolite family just get MUCH bigger? Lactate has been studied for more than a century. But only in recent years have we begun exploring the metabolites that can be “spun off” from lactate. 1/5
1
7
20
1,597
GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocorticoid signaling cell.com/cell-metabolism/ful…

GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocort...

Growth differentiation factor 15 (GDF15) suppresses liver inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis (MASH), which is independent of reduced food intake, body...

cell.com
4
206
Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity. cell.com/cell-metabolism/ful…

Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity

The mechanisms coordinating the homeostasis of glucose, lactate, fatty acids, and ketones remain unknown. Through quantitative modeling and experiments, Weilandt et al. reveal that these nutrients...

cell.com
1
5
456
Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP science.org/doi/10.1126/scia…

Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation...

Statins cause muscle side effects through an immunometabolism response that is separate from beneficial cholesterol lowering.

science.org
1
12
16
1,161
Xenophagocytosis blockade enhances interspecies chimerism sciencedirect.com/science/ar…
1
257
Advancing precision health discovery in a genetically diverse health system cell.com/cell/fulltext/S0092…

Advancing precision health discovery in a genetically diverse health system

The UCLA ATLAS biobank was utilized to integrate genetic data with electronic health records from individuals representing five continental and 36 fine-scale ancestries, identifying genotype-phenot...

cell.com
1
3
245
Distinctive DNA sequence features define epigenetic longevity of inflammatory memory science.org/doi/10.1126/scie…

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory

Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understo...

science.org
1
3
249
Jonathan Schertzer (SchertzerLab) retweeted
AJP-Endocrinology and Metabolism@AJPEndoMetabMar 24
Take a short break to review today's Mini-Review #ArticleinPress, Immunometabolism of IRF4 in Adipose, #Muscle, and Immune Cells Influences #Obesity and MASLD (Daniel Marko and Jonathan Schertzer @McMasterU): ow.ly/BCin50Yyghs
2
18
803
Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design cell.com/cell/fulltext/S0092…

Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design

A global genomic survey of infant gut bifidobacteria shows that B. infantis remains highly prevalent and diverse in infants from low- and middle-income countries but scarce in Western, industrialized...

cell.com
1
190
Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis cell.com/cell/fulltext/S0092…
3
197
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma cell.com/cell-host-microbe/f…

Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung...

Yu et al. demonstrate that Staphylococcus is selectively enriched in metastatic lung tumor lesions. Staphylococcus nepalensis and S. capitis secrete lactate to promote the metastatic potential of...

cell.com
2
232
Jonathan Schertzer (SchertzerLab) retweeted
Nature Metabolism
@NatMetabolismMar 4
TRIPping anti-tumour immunity through lactylation dlvr.it/TRHR2b

TRIPping anti-tumour immunity through lactylation

Nature Metabolism - KRAS mutations in colorectal cancers shape an immunosuppressive tumour microenvironment. In this issue of Nature Metabolism, Yang et al. report that TRIP6...

nature.com
4
16
1,878
Preprint: CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation biorxiv.org/content/10.64898…
3
267
Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease cell.com/cell-metabolism/ful…

Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-assoc...

Tang et al. reveal that high sugar intake promotes MASLD progression via microbiota-produced acetaldehyde, which drives fibrosis through MMP7 upregulation. An engineered probiotic, Ligilactobacillus...

cell.com
2
6
411
Jonathan Schertzer (SchertzerLab) retweeted
Cell Reports@CellReportsFeb 24
Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity dlvr.it/TR7qyl

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent...

Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction....

cell.com
15
53
3,869
Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity cell.com/cell-reports/fullte…

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent...

Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction....

cell.com
1
5
1
31
1,954
Jonathan Schertzer (SchertzerLab) retweeted
Cell Metabolism@Cell_MetabolismFeb 23
New! Online now: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis dlvr.it/TR6mSR
1
14
2
54
4,798
Hepatic adaptation to chronic metabolic stress primes tumorigenesis: Cell cell.com/cell/fulltext/S0092…

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Environmental stresses, such as a high-fat diet, disrupt liver cell balance by promoting pro-survival, developmental, and regenerative programs while impairing key tissue functions. These stress...

cell.com
1
7
497
Jonathan Schertzer (SchertzerLab) retweeted
Daniel J Drucker@DanielJDruckerJan 14
In humans nighttime metabolic dysfunction is a hallmark of #MASLD with multiple pathogenic pathways upregulated at night, including hepatic and peripheral insulin resistance, DNL, and systemic NEFA exposure cell.com/cell-metabolism/ful… #circadian

Human MASLD is a diurnal disease driven by multisystem insulin resistance and reduced insulin...

By studying metabolism across day and night in human participants, Marjot et al. show that MASLD is a nighttime disease driven by poor insulin action and low insulin levels. These daily patterns...

cell.com
1
14
2
70
4,101
Jonathan Schertzer (SchertzerLab) retweeted
Kevin Hall
@KevinH_PhD17 Dec 2025
It was a great pleasure to meet @richroll and discuss nutrition and metabolism science on the @RichRollPodcast!
This quoted post is unavailable.
Try viewing anyway · View on X
2
5
2
35
6,104
Load more