@SchuringaLab

Schuringa Lab at @umcg | Aiming to better understand cellular and molecular mechanisms underlying leukemogenesis 🧬 - account run by lab members

jjschuringa.wixsite.com/schuringalab
Joined April 2022
  • Tweets44
  • Following280
  • Followers242
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Happy to share that our metformin story was invited for the cover art of the latest issue of #BloodAdvances @BloodPortfolio!🩸 For those who haven’t seen it yet: doi.org/10.1182/bloodadvance… Great collaboration between @SchuringaLab @QuekLab @FrezzaLab and @jeansarry!

Metformin induces ferroptosis associated with lipidomic remodeling in AML

Key PointsThe US Food and Drug Administration–approved drug metformin induces ferroptosis with stronger impact on IDH1/2- and FLT3-mutated AML.Impairing li

ashpublications.org
Blood Journals Portfolio@BloodPortfolioFeb 10
New issue of Blood Advances out now featuring: FLT3-ITD measurable residual disease from the QuANTUM-First trial, Low bone mineral density and pain impact in adults with SCD, Antibiotic risk score for acute graft-versus-host disease and more. ashpublications.org/bloodadv…
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Luíse Simões@luisesimoes9 Dec 2024
Honored to receive the Abstract Achievement Award at #ASH24 ! I’m grateful to everyone who stopped by for the insightful discussions and to all the collaborators who made this work possible. Thank you! @SchuringaLab @ASH_hematology
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So happy to present our work at the #ASH24! I’m very honoured to be a recipient of the abstract achievement award this year. Many thanks to all the collaborators involved in this project @SchuringaLab @QuekLab @FrezzaLab @jeansarry
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Diego Martins@dap_martins15 Jun 2024
Fantastic talk from @SchuringaJan on the latest data from the @SchuringaLab about the metabolic heterogeneity in AMLs and the role of the tumor microenvironment on metabolic abnormalities/adaptation in AML at #EHA2024!
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Diego Martins@dap_martins13 Jun 2024
I am very grateful to the @young_eha committee for this opportunity to share this great collaborative work from the @SchuringaLab, #RegoLab, and @QuekLab on metabolism in AML! Looking forward to the next talks at #EHA2024!
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Exciting days at #EHAReCon2024! Got to see great science and meet some amazing people. I was also delighted with the opportunity to present our work on metformin and lipid metabolism in AML. Looking forward to next year! @EHA_Hematology @SchuringaLab
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Ayşegül Erdem@Aysglrdm2 Nov 2023
Congratulations @a_cunningham91 and @LieveOudejans and @SchuringaLab 🤩🤩👏🏻👏🏻 🌟 The 'non-essential' amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia ashpublications.org/bloodadv…

The nonessential amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia

AML cells depend on extracellular cysteine to prevent ferroptosis, which cannot be compensated by methionine.Targeting redox balance by combined inhibiting

ashpublications.org
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Diego Martins@dap_martins12 Dec 2023
Delighted to present at #ASH2023 our story on CEBPA-regulated DeltaTP73 expression mimicking TP53mut AML! Very grateul for this amazing collaboration between the @SchuringaLab, @QuekLab and the RegoLab. Pre-print coming soon!
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Diego Martins@dap_martins10 Dec 2023
Great start at #ASH2023 with Dr. @IWeinhauser presentation on metabolic vulnerabilities in AML! Great collaboration of the @SchuringaLab, RegoLab-USP/BR and the @QuekLab!
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Diego Martins@dap_martins10 Jun 2023
Delighted to present our latest story regarding the TP53-mut like AMLs at #EHA2023! Amazing collaboration between the @SchuringaLab, RegoLab and @QuekLab! Thanks @EHA_Hematology for the opportunity to present our work!
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Diego Martins@dap_martins14 Apr 2023
Very happy to share our latest article in @ScienceAdvances from @IWeinhauser about the multifaceted role of M2 macrophages driving acute myeloid leukemia aggressiveness. A fantastic collaboration between the @SchuringaLab, @QuekLab, and Rego`s Lab! science.org/doi/10.1126/scia…

M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving...

M2-polarized macrophages support leukemic transformation in vitro and in vivo.

science.org
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Intense last couple of days at #ASH2022 🩸 I’m incredibly grateful for the opportunity to show a bit of my work and for being one of the Abstract Achievement Awards recipients! @SchuringaLab @ASH_hematology
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Diego Martins@dap_martins12 Dec 2022
Great talk at the @ASH_hematology 2022 meeting from Dr. Weinhäuser @IWeinhauser about the role of M2 macrophages in AML. Very exciting data! Amazing collaboration between the @SchuringaLab and Rego's lab.
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Delighted to announce that our paper has been accepted for publication at @eLife!🥳 A huge collaborative effort from @PgGarcialab at @unibirmingham @BCGB_UoB @IcgsUob, @uguntde at @UniLuebeck, @lorena_arranz at @UiTNorgesarktis and @SchuringaLab at @umcg doi.org/10.7554/eLife.75908

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring...

Interplay between AML and stromal cells can initiate a mechanism involving gap junctions where ROS is transferred from cancer cells to stromal cells which then produce acetate which can in return be...

elifesciences.org
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Diego Martins@dap_martins23 Aug 2022
Very happy to share our recent preprint on the role of PIP4K2 inhibitors for acute leukemias! Great collaboration between the @SchuringaLab and the Machado-Neto lab!
bioRxiv@biorxivpreprint23 Aug 2022
The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy biorxiv.org/cgi/content/shor… #bioRxiv
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Diego Martins@dap_martins12 Jun 2022
Last day at @EHA2022 with this super interesting late-break session about the evolutionary landscape of clonal hematopoiesis! @SchuringaLab
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Diego Martins@dap_martins11 Jun 2022
Finishing the day with a great talk at the @EHA2022 conference! Exciting role of M2-macrophages in AML! Well done! @SchuringaLab @IWeinhauser
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Schuringa Lab retweeted
Ayşegül Erdem@Aysglrdm20 Apr 2022
Our latest work is out @NatureComms 🥳 We show how lactate fuels ITD+ AML cells upon selective OXPHOS inhibition🤩. Thanks @umcg @UniBarcelona @univgroningen @MSCActions @HaemMetabolome1 #metabolism #cancer #leukemia nature.com/articles/s41467-0…
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Ayşegül Erdem@Aysglrdm4 Mar 2022
Excited to share my 1st PhD work online in @NatureComms ⭐️We identify PDK1 as a glycolytic-regulator of different #metabolic states in acute myeloid leukemia subtypes.Thanks to @umcg @univgroningen @UniBarcelona and @MSCActions nature.com/articles/s41467-0…
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