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Lost in Space-Time ⏳
Joined November 2025
Science Unfold retweeted
A personalized mRNA vaccine cut the risk of melanoma coming back or death by 42% in a major trial. The trial, called INTerpath-001, enrolled 1,137 adults whose stage 2 to 4 melanoma had been surgically removed but who were at high risk of it coming back. All of them received pembrolizumab (Keytruda), a drug that helps the immune system attack cancer. About two-thirds also got the vaccine, which is made for each patient by reading the genetic code of their tumor and encoding up to 34 of its unique mutations in mRNA. That trains the immune system to hunt down any cancer cells left behind. After about two years, 82.2% of the vaccine group were still cancer-free, compared with 70.0% of those on the immunotherapy drug alone. Melanoma is the deadliest form of skin cancer, and this is the first time a personalized cancer vaccine has shown a clear benefit in a large, late-stage trial. The vaccine isn't approved yet, and it's too early to know if it helps people live longer, since survival data are still coming in. Side effects were mostly short-lived, like fever, sore arms and fatigue. source: Long, G. V., et al. (2026). INTerpath-001: Intismeran autogene plus pembrolizumab versus pembrolizumab alone for resected high-risk melanoma [Conference presentation]. ESMO Congress 2026.
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Meet Venus. On this planet, a single day is longer than a year.
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This star appears to be older than the universe itself. How is that possible?
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There's a planet named WASP-76b where it rains liquid iron.
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Low-dose aspirin slashed dementia risk by 70% in certain people, study shows. Researchers at Monash University in Australia went back to the ASPREE trial, a large study in which older adults took either a daily low-dose aspirin or a dummy pill (placebo). They analyzed the genetic data of more than 13,500 participants and gave each person a "polygenic score", a combined measure of many small gene variants, linked to how many platelets their blood makes. Platelets are the tiny cells that help blood clot. In the 20% of people with the highest platelet scores, just 1% of those on aspirin developed dementia, compared with 3.3% of those on placebo, about 70% lower risk. Earlier trials found aspirin didn't prevent dementia when everyone was considered together, so this points to a hidden group who might benefit, and to platelet biology as a new lead in dementia research. The signal wasn't tied to known Alzheimer's risk genes. But the same high-score group also had more major bleeding on aspirin, 4.4% vs 2.1% on placebo. This is a subgroup finding that still needs confirming in a dedicated trial. Do not start taking aspirin to prevent dementia on your own: daily aspirin can cause serious bleeding, so talk to your doctor first. source: Fransquet, P. D., Yu, C., Tran, C., Hussain, S. M., Brodtmann, A., Tonkin, A. M., Nelson, M. R., Ryan, J., McNeil, J. J., & Lacaze, P. (2026). Platelet count polygenic scores may modify the effect of aspirin in primary prevention of dementia. Alzheimer's & Dementia, 22(9).
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A teaspoon of a neutron star weighs a billion tons.
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In 2023, JWST detected the first aurora ever seen on a brown dwarf. These "failed stars" host magnetic activity we'd only seen on planets and stars before not on objects in between.
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JWST detected dimethyl sulfide in K2-18b's atmosphere in 2023. On Earth, DMS is produced almost exclusively by marine life. The detection is debated but it's the strongest biosignature candidate yet.
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JWST's infrared view of the Pillars of Creation revealed hundreds of baby stars forming inside the gas completely invisible to Hubble. The pillars aren't just clouds. They're stellar nurseries.
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🚨 JUST IN: Japanese scientists found a way to make cancer cells produce cancer-killing compounds from within in lab tests. Could this be a new direction in cancer treatment?
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JWST detected carbon dioxide in the atmosphere of WASP-39b the first CO2 detection on any exoplanet. The gas giant sits 700 light-years from Earth.
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🚨 JUST IN: Scientists restored insulin-producing pancreatic beta cells and reversed diabetes in mice. Could this lead to future diabetes treatments?
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In 2022, JWST directly imaged exoplanet HIP 65426 b the first mid-infrared direct image of an exoplanet. The planet is 9x Jupiter's mass, orbiting 350 light-years away.
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JADES-GS-z14-0 is the most distant galaxy ever observed. Its light left just 290 million years after the Big Bang when the universe was 2% of its current age. JWST found it in 2024.
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Scientists watched the brain flip between a face it was seeing and a face it was hiding, about 15 times every second. Researchers at UC Berkeley, led by Janis Hesse and Doris Tsao, recorded thousands of individual neurons in two rhesus monkeys using ultra-thin electrode probes. The monkeys looked at a trick display: one face was shown to one eye, then a second face was flashed to the other eye. The flashed face is the one people consciously see, while the first is still there but pushed out of awareness. Instead of simply silencing the hidden face, the same face-sensitive cells in the temporal and frontal lobes alternated between the two, spending about 60 milliseconds on each before switching back. That matters because scientists have long hunted for a specific spot where consciousness lives. These results hint that timing, not just location, decides what reaches awareness: the brain keeps both options alive and rapidly picks which one gets the spotlight. It's an early preprint, not yet peer reviewed, based on two monkeys. source: Hesse, J. K., Lanfranchi, F. F., McGrory, C., Shi, Y., Engel, T. A., & Tsao, D. Y. (2026). Rapid alternation of conscious and suppressed stimulus representations in the primate brain [Preprint]. bioRxiv.
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Stephen Hawking warned against broadcasting our existence to aliens. Some SETI scientists are sending messages anyway. Should we stay quiet or shout?
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What Are These Tiny Particles Doing Around This Strange, Needle-Like Structure?
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Some physicists say the multiverse is real. Others call it unfalsifiable philosophy dressed as science. Is the multiverse a scientific theory or a religion?
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String theory dominated physics for 40 years but has produced zero testable predictions. Was it a beautiful scientific dead end?
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What if your brain doesn’t actually “see” reality… but secretly builds it? 🧠
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