Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂
London, England
Joined January 2016
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New day, new cholesterol story: Researchers report astrocytic ATP-binding cassette transporter A1 (ABCA1) activity drives excessive cholesterol efflux (in mice), promoting neuronal cholesterol overload. ABCA1 is⬆️in substantia nigra of #Parkinsons brains
nature.com/articles/s41593-0…
New research identifies lysosomal remodeling based on the lysosomal chloride/proton antiporter ClC-7 & Rab accumulation as key features linking PIKfyve inhibition to LRRK2 signaling; Different combinations of Rab & GABARAP inputs activate LRRK2
rupress.org/jcb/article/225/…
Wonderful short film from Zaina Khan exploring young onset #Parkinsons (@CamilleBCarroll, @Ladybale & yours truly make cameos)
youtube.com/watch?v=NB17gyfB…
Researchers report a pathological role for α-synuclein in the CNS border tissues & position meningeal immunity as a contributor to CNS clearance deficits in #Parkinsons; α-syn at CNS borders⬆️CSF TNF & both impair lymphatic endothelial cell function
rupress.org/jem/article/223/…
Researchers report that #Parkinsons-associated LRRK2 mutations "converge on disrupted iron homeostasis across multiple human neural cell types", supporting a link between LRRK2 signaling, lysosomal iron dysregulation & ferroptosis-related stress
link.springer.com/article/10…
Viral Desulfovibrio (DSV) species have been linked to #Parkinsons. Now researchers report that DSV-derived viability-dependent processes (including metabolic activity) more strongly promote alpha-synuclein aggregation & toxicity than structural component
sciencedirect.com/science/ar…
Movement disorders neurology remains an act of watching. @janealty1 & @vertigologist explore computer vision for the detection of deterioration in #Parkinsons. But if "no effective intervention or care response is available, have we actually helped"?
nature.com/articles/s41531-0…
Mission Therapeutics @MISSIONTherapeu announces dosing of first #Parkinsons patient in the Phase 1b study of their USP30 inhibitor MTX325. The study is taking place in UK, Europe & Australia. Readout is anticipated in late 2027
missiontherapeutics.com/miss…
Using large-scale hospital electronic health records of the University of California health system (n=890K hypertensive patients), researchers report Angiotensin receptor blockers irbesartan & olmesartan were associated with lower incident #Parkinsons risk
onlinelibrary.wiley.com/doi/…
XellSmart presented 6 months post-transplant data for their Phase I trial of their off-the-shelf #Parkinsons cell therapy XS411, & announces successfully completion of enrollment for the Phase 2 trial of XS411
prnewswire.com/news-releases…
Something researchers to explore: The GBA1 Canada initiative (G-can) - a pre-competitive, collaborative, open-science platform accelerating research & treatment development for GBA1-related #Parkinsons
journals.sagepub.com/doi/10.…
New research suggests dietary patterns/habits in isolated REM sleep behavior disorder is associated with gut microbiome dysbiosis & predicts neurodegenerative progression, highlighting diet–microbiome interactions as modifiable factors
movementdisorders.onlinelibr…
Researchers virtually screen of 9.4k compounds (2.6k FDA-approved drugs, 6.7k African natural products) against the ATP-binding pocket of LRRK2-G2019S, & identify Rimonabant, Gallagic acid, Acalabrutinib, & Atovaquone as repurposable candidates
nature.com/articles/s41598-0…
Researchers report a case of #Parkinsons caused by a de novo SNCA triplication with longitudinally evaluated gene expression in whole blood & platelets at 2 disease stages: early PD (age 41) & Parkinson's disease dementia (age 44)
movementdisorders.onlinelibr…
New research from the GP2 team finds that the GCH1 p.Ser80Asn variant is a rare, East Asian-enriched risk variant for #Parkinsons
movementdisorders.onlinelibr…
Another week, another paper for @GeorgeTofaris & colleagues
This week, they report the epitope accessibility & topology of extracellular vesicle-associated α-synuclein proteoforms, rather than their abundance alone, discriminate synucleinopathy subtypes
academic.oup.com/brain/advan…
New review explores resilience & vulnerability in the midbrain dopamine system during aging; "Elucidating these neuroadaptive mechanisms could offer a path toward preserving dopamine neuron function across the lifespan" & possibly preventing neurodegen.
cell.com/trends/neuroscience…
New editorial raises concerns about Vitamin B6 levels in #Parkinsons, & the need for monitoring them
movementdisorders.onlinelibr…
Towards a better definition of patient-centered therapeutic strategy of #Parkinsons: A new opinion paper proposes "pragmatic, consensus-based principles for fully individualized, preference-sensitive pharmacological care across the patient journey"
link.springer.com/article/10…
