Biotech entrepreneur and consultant. Biochem PhD. Opinions strictly my own.

Massachusetts, USA
Joined September 2018
Poll for biotech entrepreneurs and biotech/pharma BD folks: What do you use for your fundraising or BD tracker? I personally use excel, which I kind of hate. If you use software or SaaS, please reply with the name. Thanks!
45%Excel or Google Sheets
12%Software or SaaS app
43%Show me the answers
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IMO… it is a mistake to “try to increase U.S. competitiveness through protectionism.” The new rule “may make it easier for non-U.S. companies to succeed through manufacturing in China. This wouldn’t help our global competitiveness.” IMO… let’s instead kick ass with American ingenuity! biocentury.com/article/66129…
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This is a meaningful step to bring better coordination around FDA initiatives to make the process for developing treatments for rare diseases more efficient. Will help accelerate new policy development. bloomberg.com/news/articles/…
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Rob Shaffer retweeted
As a father to three children under seven, protecting our streets and schools from violent crime is top of mind. That means saying no to dangerous ideas, regardless of politics. In 2026, the No on Question 9 campaign wants to get rid of sensible gun safety laws. On Nov. 3, join me in voting Yes on Question 9, Yes for civil rights, and Yes for public safety.
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Gaza Ministry of Health has now released mortality numbers for 2025. For the first time since the war, they give numbers for all deaths, including natural deaths. In 2025 there were a total of 24,650 deaths in Gaza. 18,870 (76.6%) of these were violent, of which 17,286 (70.1%) were due to "war operations" and 1,584 (6.4%) were classified as accidents. There were a total of 5,780 (23.4%) non-violent deaths, including disease, old age, and all other causes. 5,780 deaths is about the same as the annual non-violent mortality in Gaza before the war, and the age distribution is similar to 2022. There is no significant excess of non-violent deaths. In other words, despite frequent and loud claims to the contrary, there seems to be very few indirect deaths due to the war in Gaza in 2025. As there were 50,227 births in 2025, this gives a natural population growth of 25,577 or 1.2% in Gaza in 2025, which is higher population growth than most countries in the world and more than the world average. There are currently ~6,000 births/month in Gaza, per GMH. Assuming a similar number of non-violent deaths in Gaza in 2026 as in 2025, that means there are currently 12x more births than deaths in Gaza, and that Gaza is now experiencing one of the highest population growths in the world.
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Rob Shaffer retweeted
Useful free tool tracks a number of key parameters in one place based on regulatory filings rather than press releases (changes to endpoints/timelines, funding runway and catalyst timing discrepancies, ownership etc). Katogen.com/radar by @insidepharma $XBI $IBB $BBC
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AEI senior fellow @ScottGottliebMD joins CNBC's ‘Squawk Box’ to discuss concerns over food safety and FDA's handing of the recent Cyclospora outbreak.
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Rob Shaffer retweeted
I wonder if the Trump administration knew about this bit of news from Dec 2009: "Merck & Co. Inc. has announced that it will not resume production of single antigen component measles, mumps and rubella vaccines... Monovalent measles, mumps and rubella vaccines are not needed. Their use would unnecessarily delay administration of the three vaccine components, leaving children susceptible for a longer period of time to serious, life-threatening diseases. Use of monovalent vaccines also would increase the number of injections a child would need and increase the number of visits required to complete the vaccination series." publications.aap.org/aapnews…
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Rob Shaffer retweeted
No. The EO can’t split up the MMR vax. A company would have to do clinical trials to bring the 3 vax thru the approval process, taking years. However the EO does undermine confidence in the MMR vax as measles roars back in the US, hastening our backwards slide.
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Rob Shaffer retweeted
Senator Bill Cassidy - a medical doctor and liver disease specialist - cast the deciding vote to confirm @SecKennedy and spoke on the floor about the assurances he received that Kennedy - and the admin - would not change existing vaccine recommendations.
I’m a doctor. This executive order is wrong. The President does not have the expertise to make these changes. Vaccines are overwhelmingly safe. Vaccines are effective. Vaccines DO NOT cause autism. Breaking up vaccines will mean children have to get more shots to get the same protection, not fewer shots. It will increase hesitancy and make children less safe. Parents should listen to their child’s pediatrician about vaccines rather than listening to an inaccurate executive order. This is so wrong. xitter.cf/axios/status/208688294…
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Rob Shaffer retweeted
article on biotech innovation for fortune mag's US 250th anniversary series. the next decade is going to be amazing, don't miss it. the challenge will be to navigate an affordability crisis in hospitals and services without breaking our drug innovation engine. fortune.com/2026/07/25/pancr…
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Rob Shaffer retweeted
Replying to @AppleHelix
I am excited to hear why we should now go ahead and ban this drug from being used in the US simply because it was invented in China. Instead, American patients should just keep using the inferior existing therapy so that a few parties with vested interests can be shielded from competition.
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Thanks for asking @jrkelly. It highlights why you and your hawks are not quite getting it here. This is about finding the best innovation for patients from anywhere in the world. I fully expect the cost of developing these assets in the U.S. will be largely the same. For e.g., the Akeso/Summit anti-PD1/VEGF bispecific was discovered in China. Summit was excited about the data and in-licensed it for ex-China rights. Summit is doing robust global clinical studies to demonstrate safety and efficacy. If successful, American patients will get access to a best-in-class immunotherapy that could be a game changer. To my knowledge, there wasn’t an alternative PD1-VEGF bispecific discovered in the U.S. Also, there was no stealing of IP by Akeso to make their drug. Why is this different than Merck sourcing Keytruda from Belgium? So, let’s not use walls to block access to innovation from ANYWHERE in the world especially when it can help US patients. Of course, IP MUST be respected, or the “discovery” is a violation of international law. To clarify one other point, I also want the U.S. to be the indisputable global leader in biotechnology! China’s increased prominence must be a SPUTNIK moment for our country. We should reverse the self-inflicted damage to our innovation ecosystem that includes decimated NIH funding, an anti-science/anti-vaccine/anti-“expert” rhetoric that threatens discourse, a restricted H-1B visa program blocking our ability to recruit the best in the world, a chaotic FDA where innovators and drug developers face enormous uncertainty and undue regulatory hurdles and costs, an effort to break our innovation reward system with drug price controls through Biden-era IRA and Trump-era MFN, a post-COVID hybrid workforce approach that has American’s working less, and more. I, for one, believe that we can WIN with good ole American ingenuity if we course correct on the above. I’m certain that will work. We have the greatest scientists in the world and lead in disruptive innovation while others are making progress in incremental innovation. For those of you that advocate for walls, I don’t think it will be successful. AND, I’m certain American patients will suffer. My $0.02.
"Here’s an idea: maybe we can measure the cost per drug sourced from China relative to the US, and perhaps drug prices in the US should be adjusted to reflect their country of origin. If there is an outcry from pharma and venture funds, then you will know that this movement is purely about development costs and has nothing to do with doing what is best for patients." Yeah agreed - @JMaraganore would this work?
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Rob Shaffer retweeted
Patient-first, America-first: The Case For Global Collaboration. While the rise of Chinese biopharma in the past decade has been meteoric, I’m firmly in the camp that their engagement in the global ecosystem is good for the sector – its more opportunity than threat, great for patients, and is a healthy forcing function to raise the game for everyone New blog link 👇
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Rob Shaffer retweeted
Pharma CEO silence is complicity in the destruction of U.S. science. Office of Management and Budget Director Russell Vought has poured gas on the foundations of science. Pharma CEOs should demand that President Donald Trump take away the matches. For more than a year, the Trump administration has been weakening the institutions that made the United States the global leader in biomedical innovation. This week, Vought revealed that the objective is not merely to shrink the federal research enterprise, but to make it subservient to political and ideological objectives. Vought’s proposed rule would require senior political appointees to review and approve every discretionary federal grant before it is awarded, explicitly barring them from deferring to peer reviewers, and would mandate that all grant programs align with the president’s policy priorities, rather than scientific need or expert consensus. It seeks to introduce ideological tests on applicants and institutions that receive grants, bar most international scientific collaboration, and allow political appointees to cancel grants at any time without providing an explanation. The proposal also would allow agencies to make grants that haven’t been publicly announced, opening the process to corruption and favoritism. If implemented, the proposal would represent the most serious assault on U.S. science since World War II. Even those who agree with the Trump administration’s views on social and political issues should be alarmed. Future administrations with very different views may not abandon the temptation to wield control over scientific funding to advance ideological agendas. More at biocentury.com/article/65961… (no paywall).
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Rob Shaffer retweeted
A few people have asked me to comment on this article & the topic of US biotech competitiveness vis-à-vis China. I agree w/ Peter & Tess that expanding the COINS Act to biotech would have negative consequences. Risks handing global leadership & profits to EU competitors while doing little to slow China’s dominance. Also agree that we must protect critical supply chains/manufacturing from a national security perspective. While COINS for biotech is a bad idea, we need proactive legislation to strengthen US biotech innovators. Targeted measures could include tradable/refundable R&D tax credits (noted in article) & priority review vouchers (@rtnarch), NOL reforms (amending Section 382), enhanced data exclusivity for genuine first-in-class assets & patent reform. These could level the playing field for US innovators without the protectionism & restrictions that would raise costs & slow patient access to new medicines
The paradox of biotech protectionism: Why walling off China biotech weakens America US ban on Chinese biotech/trials would return pharma leadership to Europe, slow US patient access to new meds, & lead to US dependency protectionism claims to prevent. rapport.racap.com/all-storie…
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The paradox of biotech protectionism: Why walling off China biotech weakens America US ban on Chinese biotech/trials would return pharma leadership to Europe, slow US patient access to new meds, & lead to US dependency protectionism claims to prevent. rapport.racap.com/all-storie…
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Asked mid-season about the Yankees, former Red Sox General Manager Theo Epstein once said that he had looked at their roster at the start of the season, realized that they'd win 100 games, and now ignored their weekly standings in order to focus on his own roster's ability to compete. I raised this anecdote at a recent roundtable of experts discussing China's rise in biotechnology. China is uplifting scientists, investing hundreds of billions in R&D, and accelerating clinical trials. It's going to win 100 games. The center of biomedical gravity is moving to China from America, just like it moved from Europe to America at the close of last century. Unless America decides to win 110 games. statnews.com/2026/05/18/biot…
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Rob Shaffer retweeted
I'm a middle eastern historian. My own family were made refugees. And this is my honest view of the Nakba (“catastrophe”) - the displacement of around 700,000 Palestinian Arabs during the 1947–49 war surrounding the creation of Israel. A thread. 🧵
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