@Sharpe_Lab

Group based @BabrahamInst in Cambridge. Interested in #phosphatases. She/her. Now on BSky - see you over there.

 Cambridge, UK
babraham.ac.uk/our-research/signalling/hayley-sharpe
Joined April 2016
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  • Following465
  • Followers696
8Media
In the words of the great @mjafreeman "Pseudoenzymes are a thing". Come and check out how much of a thing at the upcoming EMBO workshop this June - registration now open: meetings.embo.org/event/24-p… #pseudoenzyme

Pseudoenzyme functions across life - challenges and opportunities

A significant number (~10%) of enzymes are pseudoenzymes, defined by deviations in catalytically-important residues. Despite the lack of catalytic activity, pseudoenzymes impact almost all cell biolo…

meetings.embo.org
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Check out our newly updated proteostasisuk.co.uk/. If you are working in the UK on #proteostasis, please consider listing your lab and filling out the survey.

ProteostasisUK

proteostasisuk.co.uk
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Calling teachers! Register now for the Babraham Institute Sixth Form Conference 2024 – a special event where young people get to experience a taste of a real-life academic conference. Full details: bit.ly/BabrahamSFC
Sixth form conference 2024 theme: proteostasis

ALT Sixth form conference 2024 theme: proteostasis

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👋Job alert! We are recruiting 2 group leaders working in the field of cancer cell biology to join our centre at @QMBCI @QMUL. Come and join us 🤩 👉Get in touch if you have any questions!
Barts Cancer Institute (Queen Mary)@QMBCI22 Aug 2024
🚨 We have two exciting group leader opportunities for scholars with a passion for cancer cell biology: one Reader and one Senior Lecturer position. Join us! ➡ Reader: bit.ly/3Mfk3bd ➡ Senior Lecturer: bit.ly/3MgTanf 📆 30.09.24
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Hayley Sharpe retweeted
Daniel Fazakerley@DPhaz13 Aug 2024
Deadline for applications for this potdoc postion in our group is the end of August. Please get in touch if you would like additional information. Link: tinyurl.com/57ea9p3f
Daniel Fazakerley@DPhaz6 Aug 2024
We are looking for a Postdoc to investigate novel genes that regulate insulin-stimulated glucose transport (tinyurl.com/ycarykzh). MRC-funded collaboration with O'Rahilly (@StephenORahilly) @IMS_MRL & Langenberg groups (QMUL). Please RT. Link: tinyurl.com/57ea9p3f
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We're recruiting! Please spread the word. We're excited for someone to join our team with an interest in biochemistry and/or cell biology. The project will focus on cellular redox reactions that locally activate switches in protein complexes to drive signalling.
Babraham Institute@BabrahamInst6 Aug 2024
VACANCY: Postdoctoral Research Scientist If you have expertise in cell communication and redox signalling this is the job for you! Join the Sharpe lab as they investigate intercellular communication across different systems. Deadline: 30th August Details: ow.ly/nHNE50SSeYt
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Did you see the latest research from @KatieYoung1995 @Sharpe_Lab: new findings on the role of PTPRK in tissue repair and cancer? 💡Including the extent of its function via non-catalytic signalling mechanisms babraham.ac.uk/news/2024/07/… @J_Cell_Sci
Image shows three immunofluorescent images of mouse colons stained for nuclei (DAPI;blue) and cellular junctions (ZO1; green). Text reads: News - Research sheds light on the role of PTPRK in tissue repair and cancer

ALT Image shows three immunofluorescent images of mouse colons stained for nuclei (DAPI;blue) and cellular junctions (ZO1; green). Text reads: News - Research sheds light on the role of PTPRK in tissue repair and cancer

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Hayley Sharpe retweeted
J Cell Science@J_Cell_Sci24 Jul 2024
Katherine Young @KatieYoung1995, Hayley Sharpe @Sharpe_Lab @BabrahamInst and colleagues discover that PTPRK promotes intestinal repair and catalysis-independent tumour suppression. Highlight: journals.biologists.com/jcs/… Article: journals.biologists.com/jcs/…
Heatmap showing differential gene expression between WT and PTPRK KO HT29 cells that was rescued by reintroduction of PTPRK and/or PTPRK.RQ. Graph of Gene ontology (GO) analysis of genes suppressed by PTPRK showing an overrepresentation of genes annotated with the biological processes ‘epithelial to mesenchymal transition’ and ‘mesenchymal cell differentiation’, as well as Wnt signalling. Amongst genes that were upregulated by PTPRK, GO analysis revealed overrepresentation of genes annotated with the terms ‘negative regulation of epithelial cell proliferation’ and ‘regulation of cell migration’. Also, graph showing a ∼2-fold upregulation of Ptprk in organoids treated with TGFβ1 in the RNA-seq data from two out of three published studies. Finally, a graph showing that organoids mutant for P53 and KRas harbouring the Notch1 ICD showed significantly reduced levels of PTPRK.

ALT Heatmap showing differential gene expression between WT and PTPRK KO HT29 cells that was rescued by reintroduction of PTPRK and/or PTPRK.RQ. Graph of Gene ontology (GO) analysis of genes suppressed by PTPRK showing an overrepresentation of genes annotated with the biological processes ‘epithelial to mesenchymal transition’ and ‘mesenchymal cell differentiation’, as well as Wnt signalling. Amongst genes that were upregulated by PTPRK, GO analysis revealed overrepresentation of genes annotated with the terms ‘negative regulation of epithelial cell proliferation’ and ‘regulation of cell migration’. Also, graph showing a ∼2-fold upregulation of Ptprk in organoids treated with TGFβ1 in the RNA-seq data from two out of three published studies. Finally, a graph showing that organoids mutant for P53 and KRas harbouring the Notch1 ICD showed significantly reduced levels of PTPRK.

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📢 #postdoc role available! 📢 Application deadline is 🌟16th July 2024🌟 Please get in touch if you're interested! kcl.ac.uk/jobs/087846-resear…
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Thanks @FIDATechnology for sponsoring #embopseudoenyzme Awesome technology, so many applications.
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Everything ran on time, unlike the flights! #embopseudoenzyme
Hayley Sharpe@Sharpe_Lab9 Jun 2024
Speeding through the French countryside on the TGV en route to #EMBOpseudoenzyme near Girona.
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Hayley Sharpe retweeted
Hayley Sharpe@Sharpe_Lab9 Jun 2024
Speeding through the French countryside on the TGV en route to #EMBOpseudoenzyme near Girona.
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Speeding through the French countryside on the TGV en route to #EMBOpseudoenzyme near Girona.
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We're starting to recruit postdocs to work on this exciting ERC (now UKRI) project. Please get in touch if you would like to join us, or spread the word. #phosphatases #redox #Tcells @SFRR_Europe @ListerInstitute @EMBO_YIP
Babraham Institute@BabrahamInst23 Nov 2023
NEWS | Congratulations to Dr Hayley Sharpe @Sharpe_Lab @EMBO_YIP on the award of her @ERC_Research Consolidator grant to study the unsolved mystery of T cell signalling.
Inset image of Dr Hayley Sharpe, set over a false-coloured image of phagocytic primary macrophages expressing a fluorescent reporter to detect cellular hydrogen peroxide production (shown by yellow/orange colouring). Text reads: News - Dr Hayley Sharpe receives an ERC Consolidator Grant

ALT Inset image of Dr Hayley Sharpe, set over a false-coloured image of phagocytic primary macrophages expressing a fluorescent reporter to detect cellular hydrogen peroxide production (shown by yellow/orange colouring). Text reads: News - Dr Hayley Sharpe receives an ERC Consolidator Grant

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Hayley Sharpe retweeted
Redox UK@RedoxUk21 Mar 2024
Programme for 2024 Thiol-Redox Gordon Conference now online. Exciting array of topics and speakers with 16 talks still to be selected from abstracts grc.org/thiol-based-redox-re… Great opportunity for Early Career Researchers to present their work in the GRS too.grc.org/thiol-based-redox-re…
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I can't wait to hear more of the groundbreaking new Redox research that will be presented at grc.org/thiol-based-redox-re… Still a few places left, but you need to apply/reigster ASAP -especially if you would like to join as one of 16 selected speakers! Also grc.org/thiol-based-redox-re…
Elizabeth Veal@ElizabethVeal921 Mar 2024
Programme for Thiol-Redox GRC now online grc.org/thiol-based-redox-re… Lots of talks to be selected from abstracts -so get your applications in and join the friendly thiol-redox community for exciting scientific discussions by the Mediterranean!
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Have you secured your spot at next week's talk from Prof Clare Bryant as part of our Babraham Distinguished Lecture Series? Clare is Professor of Innate Immunity at the Departments of Medicine and Veterinary Medicine in the University of Cambridge. Info - ow.ly/9WaT50RyrNk
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Hayley Sharpe retweeted
Seema Grewal@seemasainson7 May 2024
We’re hiring! We’re looking for a Reviews Editor to work across our journals (@Dev_journal, @J_Cell_Sci, @J_Exp_Biol, @DMM_Journal). If you’ve got excellent communication skills and a broad interest in science, this is a job for you! Location: Cambridge UK biologists.com/about-us/work…

Work for us

Explore career opportunities at The Company of Biologists. Join a team passionate about science, publishing and community support.

biologists.com
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Interested in antibody responses? Interested in joining our team? We will move to the Babraham Institute, Cambridge very soon, and currently have three vacancies. Two postdocs babrahaminstitute.livevacanc… and a research assistant babrahaminstitute.livevacanc…
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#EMBOpseudoenzymes Registration deadline 30th April. Late breaking abstracts for posters still accepted.
Hayley Sharpe@Sharpe_Lab22 Apr 2024
Abstract submission deadline *today* if you want to be considered for a talk. Late breaking abstracts for posters can be sent to me until the registration deadline at end of April! meetings.embo.org/event/24-p… #EMBOpseudoenzyme @Co_Biologists

Pseudoenzyme functions across life - challenges and opportunities

A significant number (~10%) of enzymes are pseudoenzymes, defined by deviations in catalytically-important residues. Despite the lack of catalytic activity, pseudoenzymes impact almost all cell biolo…

meetings.embo.org
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