Postdoc in @ElowitzLab @Caltech. Ph.D. with @CarolynBertozzi @Stanford.
Joined June 2013
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Judy Shon retweeted
Excited to share our new study in @Nature! We uncover how the vascular glycocalyx—a carbohydrate-rich coating on blood vessels—plays a crucial role in brain health and aging. A @wysscoray & @CarolynBertozzi labs collaboration. 🍭🧠 #glycotime (1/12)
nature.com/articles/s41586-0…
Judy Shon retweeted
Thrilled to share our work on novo protein LYTAC(pLYTAC)/EndoTag in @nature! Using de novo protein design, we created endocytosis triggering binding proteins (EndoTags) to degrade extracellular targets and amplify receptor signaling. nature.com/articles/s41586-0…
Judy Shon retweeted
Excited our final version of @tineisadora's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. @Stanford_ChEMH @StanfordUChem nature.com/articles/s41586-0…
Judy Shon retweeted
Delivering and expressing a gene in cells is usually a messy (heterogeneous) process. The messiness interferes with research and applications such as gene therapy.
In two new papers, we introduce a toolbox of synthetic miRNA-based control circuits that enable more precise, gene dosage-invariant gene expression, and show how they improve a mouse model of Rett syndrome gene therapy:
biorxiv.org/content/10.1101/… ,led by @RongrongDu123 and @MichaelJAFlynn
biorxiv.org/content/10.1101/… , led by @MichaelJAFlynn and Acacia Mayfield, in collaboration with Viviana Gradinaru.
Judy Shon retweeted
Our paper on lineage motifs is now online at @Dev_Cell 😀 We hope that this approach will be widely useful for anyone interested in analyzing tree-type datasets!
Online now: Lineage motifs as developmental modules for control of cell type proportions dlvr.it/T2lKM6
Judy Shon retweeted
Out now on @biorxivpreprint!
In my first project in the @ElowitzLab, we explore how competitive, "many-to-many" dimerization allows complex, multi-input, and cell-type-specific biochemical computations🧵↓
doi.org/10.1101/2023.10.30.5…
Judy Shon retweeted
New preprint: Networks of dimerizing proteins turn out to be powerful computational systems. In tweetorial form here by @JacobParresAu, who led this work with @BenEmert, Matt Levine, and Andrew Stuart.
Out now on @biorxivpreprint!
In my first project in the @ElowitzLab, we explore how competitive, "many-to-many" dimerization allows complex, multi-input, and cell-type-specific biochemical computations🧵↓
doi.org/10.1101/2023.10.30.5…
Judy Shon retweeted
Excited to share my PhD work, out now in @ScienceMagazine ! What governs successful lysosomal degradation of membrane proteins mediated by extracellular degraders? Can we improve degradation efficacy? science.org/doi/10.1126/scie…🧵(1/n)
Judy Shon retweeted
Excited to share this work from @tineisadora! Precise control over protein subcellular localization could have massive implications for gain-of-function therapeutic strategies. We showcase targeted relocalization activating molecules (TRAMs) for rewiring interactomes. (1/n)
Targeted Protein Relocalization via Protein Transport Coupling biorxiv.org/cgi/content/shor… #bioRxiv
Judy Shon retweeted
🎉🎉Super excited to announce that our manuscript on T cell immunoglobulin and mucin-domain containing (TIM) proteins was published in @NatureComms! We used glycoproteomics to drive MD simulations and understand how #glycotime affects structure/function:
doi.org/10.1038/s41467-023-4…
Judy Shon retweeted
Want to sequence RNA from cells without killing them or deliver RNA programs from cell to cell? Today in Cell, we present RNA exporters, which package and secrete cellular RNA, for non-destructively monitoring cell dynamics by sequencing and delivering RNA authors.elsevier.com/sd/arti…
ALT An engineered RNA export system enables non-destructive monitoring of cell dynamics and delivery of RNA from cell to cell.
Judy Shon retweeted
RNA is informant and agent. Controlled RNA export from cells could enable cell-cell delivery of functional and non-destructive tracking of cell dynamics. Our new paper, led by brilliant @FelixHorns, engineers RNA export for both capabilities: authors.elsevier.com/sd/arti…
Judy Shon retweeted
🚨🚨New #mucinome preprint! We used glycoproteomics and MD simulations to understand TIM-3/4 stx/fxn! Buckle up for this wild ride that involved collaborative #glycotime efforts from so many, esp @joann_chong @A_Steigmeyer @keira_erol @mia_rosenfeld 🧵👇biorxiv.org/content/10.1101/…
Judy Shon retweeted
To map cellular sources of the dynamic circulating proteome, we (@WeiWei_Stanford, @LyuXuchao, @longlabstanford, @CarolynBertozzi, and more) expanded our cell-type selective secretome strategy to generate a 21-cell type, 10-tissue map of exercise-regulated secretomes in mice.
Organism-wide secretome mapping uncovers pathways of tissue crosstalk in exercise biorxiv.org/cgi/content/shor… #bioRxiv
Judy Shon retweeted
Excited to share our new @biorxivpreprint! We developed antibody-lectin (AbLec) chimeras as a modular molecular architecture to target sugars, or glycans, for cancer immunotherapy. 1/n tinyurl.com/5yw69eeu #glycotime @CarolynBertozzi @Stanford_ChEMH @StanfordUChem @HHMINEWS
Judy Shon retweeted
BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
Judy Shon retweeted
We hope this can be a useful platform for defining endogenous mucin-domain glycoproteins in complex biological systems. Challenges certainly still remain, but this can be one option to make mucin-centric #glycotime questions more approachable.
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Judy Shon retweeted
THE #MUCINOME HAS FINALLY BEEN REVEALED! Huge thanks to co-first author @riley_nm1, co-authors @ShonJS, @KayvonPedram, Venkat and Oliver, and of course our fearless #glycotime leader @CarolynBertozzi. Out now in @NatComm: rdcu.be/cP1Qu
Judy Shon retweeted
Fearless grad student @veronical1411 led this team science effort to answers the question, why don't you feel hungry after a hard workout? @nature @SnyderShot @StevenMBanik @proferikrichter @DrYongXu1 @Stanford_ChEMH @StanfordPath @WuTsaiAlliance nature.com/articles/s41586-0…