Systems biology @bsmsMedSchool | UKRI Future Leaders Fellow | co-director @sussex_cancer | Speciality Chief Editor: Systems Immunology @FrontImmunol
Brighton
Joined May 2008
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Proud to have worked on this project led by Emma Kennedy and @andrea_pepper2. Our systems biology models helped show why leukaemia cells respond differently across patients.
Blood @BloodPortfolio
ashpublications.org/blood/ar…
@BSMSMedSchool @Sussex_Cancer @uniofbrighton @SussexUni
🔬 New research involving our funded researcher Prof. Simon Mitchell @SiFTW is helping reveal why CLL responds differently to treatment between patients, including how leukaemia cells can change their survival strategy when treatment stops working.
Read more: ashpublications.org/blood/ar…
ALT A researcher wearing glasses and a white lab coat stands in a laboratory. Text reads: “New paper: Revolutionary study combines computer modelling and lab experiments to uncover new insights into CLL. Prof. Simon Mitchell.” Leukaemia UK logo appears at the bottom.
Huge thanks to @LeukUK and their supporters for making this possible and supporting our work from the ground up. We wouldn't be here without you!
Along with @The_MRC for the award to Prof Andrea Pepper that funded Dr Emma Kennedy, and @UKRI_News for the FLF that supports our lab
Simon Mitchell retweeted
Good luck to Dr Aimilia Vareli from the @SiFTW group in @BSMSMedSchool who's moving to Boston Children's Hospital and Harvard Medical School.
Follows on from winning 1st prize for best short talk at the annual NFkB meeting in Barcelona for her work targeting in DLBCL! 👏👏👏
Simon Mitchell retweeted
Busy month for our NFkB research teams in
@BSMSMedSchool!
@SiFTW & @ChrisPepper64 groups visited and presented at the annual NFKB meeting in Barcelona, then at the Brighton Tumour Microenvironment conference with Simon presenting the lab's latest data at both meetings!
👏👏👏
We’re excited to announce that we’re looking for a postdoctoral research to join our team!
This is an opportunity to lead an exciting project aiming to push the boundaries of personalised medicine through integrating data, simulation and lab experiments.
mitchell.science/talk/we-are…
Simon Mitchell retweeted
We're excited to annoucen that @SxCancerFund SCRC research awards are open for applications, with funding up to £10k or £30k. Priority areas include data science, population datasets, prevention, early diagnosis, and mental health.
sussexcancer.org/funding
Simon Mitchell retweeted
✨ How is BSMS lighting the way in cancer research?
Dr Simon Mitchell (@SiFTW) & Prof Melanie Flint share the mission at the Sussex Cancer Research Centre: pioneering interdisciplinary research that will improve cancer treatments & outcomes. @Sussex_Cancer
youtube.com/watch?v=w8YlZPuI…
Excited to have been promoted to Professor in Cancer Systems Biology at @BSMSMedSchool, @SussexUni, @uniofbrighton
Reflecting triggers imposter syndrome tbh. But I owe it to a series of advisors/supervisors/mentors who believed in me and my approaches.
Particularly, Pedro Mendes, @ahoffmann2716, and @ChrisPepper64, who supported me in so many ways from PhD, to postdoc, and PI respectively.
I especially owe this promotion to the incredible and inspiring scientists that I’m fortunate enough to call my team, collaborators, and co-directors of @Sussex_Cancer
I’m most excited to use my position to repay some of the incredible support I’ve had by supporting others.
🍻
Simon Mitchell retweeted
Very grateful to have been awarded our 1st @bloodcancer_uk @BloodCancer_Res research grant over the summer for our work targeting aberrant Wnt/β-catenin signalling in acute myeloid leukaemia (AML).
New project begins Oct 1st developing new ways to target oncogenic β-catenin 👊
I’ll forever be grateful to @LeukUK and their supporters for being the first to support our work using simulations to tailor treatments in blood cancer.
Our lab @BSMSMedSchool and @Sussex_Cancer exists because of you.
It was fun to share some of what I’ve learned with ECRs today.
“There’s no way I’d be sitting in front of you now if I didn’t receive the John Goldman Fellowship.”
Some established researchers share their experiences and advice for those starting out in the field. 🔬🧡
ALT Four people are sitting in a line behind a table, forming a panel. A presentation screen behind them reads, ‘Early Career Researcher support’.
Simon Mitchell retweeted
“There’s no way I’d be sitting in front of you now if I didn’t receive the John Goldman Fellowship.”
Some established researchers share their experiences and advice for those starting out in the field. 🔬🧡
ALT Four people are sitting in a line behind a table, forming a panel. A presentation screen behind them reads, ‘Early Career Researcher support’.
Simon Mitchell retweeted
Have you or a loved one experienced cancer?
We’re looking for volunteers with lived experience of cancer to join our Experts by Experience panel.
Your voice can help shape the future of cancer research in Sussex.
Apply here: sussexcancer.org/experts
Apply by 30/09/2025
Simon Mitchell retweeted
Congrats to our John Goldman Fellow, @SiFTW and team! Their research shows how lymphoma cells evade treatment by switching between “survival” pathways. The team have discovered how to predict and overcome this resistance, which could lead to more tailored treatments. 👏
New paper led by Aimilia Vareli out now.
nature.com/articles/s41419-0…
The lymphoma microenvironment stops BH3-mimetics from working.
In vitro/vivo/silico, we find that inhibition of NFκB makes BH3-mimetics great again.
1/🧵
@Sussex_BCR @Sussex_Cancer @LeukUK @BSMSMedSchool #UKRIFLF
New paper led by Aimilia Vareli out now.
nature.com/articles/s41419-0…
The lymphoma microenvironment stops BH3-mimetics from working.
In vitro/vivo/silico, we find that inhibition of NFκB makes BH3-mimetics great again.
1/🧵
@Sussex_BCR @Sussex_Cancer @LeukUK @BSMSMedSchool #UKRIFLF
Finally, we find that despite all this complexity there is one strategy that always works to overcome the TME.
Inhibition of the key regulator of non-canonical NF-kB (NIK) totally neutralises the drug resistance caused by the TME in DLBCL🎉
5/🧵
