Our goals are to understand the biology of pediatric sarcomas, generate new models and provide better therapeutic strategies for sarcoma patients.
Heidelberg, Germany
Joined October 2019
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A critical gap in sarcoma research has been the lack of flexible immunocompetent models. Here we show that efficient somatic gene delivery to mouse muscle enables to faithfully model various sarcomas in mice. Check out our new preprint👇
Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma biorxiv.org/cgi/content/shor… #bioRxiv
Thrilled to receive an #ERCCoG grant from @ERC_Research! Huge thanks to my amazing lab members—past and present—my family, and the incredibly supportive environment @DKFZ @KiTZ_HD.
Excited to advance research on pediatric sarcomas. Stay tuned, and congrats to all awardees!
📢 Results of the 2024 ERC Consolidator Grant competition are out.
€678 million for 328 researchers.
Who won funding?
What will they investigate?
Where will they conduct their research?
#ERCCoG news 👉 europa.eu/!gWqYfc
🇪🇺 @HorizonEU
Super cool! Congratulations!
Excited to share a new paper from our group. A shout-out to Tony Hill (@ccortical ) that spearheaded the first single cell atlas of choroid plexus tumors!
Single-nucleus RNA-seq dissection of choroid plexus tumor cell heterogeneity | The EMBO Journal embopress.org/doi/full/10.10…
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Pancho is a great mentor and scientist. Apply 👇
We have an open postdoc position in my group! The projects of the lab are focused on understanding how cancer genomes dictate immune responses, tumor evolution, and therapy resistance. Come join us in a great environment!
vhio.net/2024/09/18/ref-2024…
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Beautiful work!
🎉 Excited to share our latest study in @nature, showing that DNA🧬 #methylation is key to stemness in the adult #brain: nature.com/articles/s41586-0…
A collaboration with @s_anders_m, driven by @LPMKremer and @SCerrizuela. #epigenetics #neuroscience #singlecell. Pre-print summary 🧵👇
ALT Top: Schematic depiction of genes involved in astrocyte function and neurogenesis, and their methylation and gene expression status in different cell states. Bottom: We propose that DNA methylation locks common parenchymal astrocytes in their astrocyte fate by repressing genes required for neurogenesis. By contrast, these genes are demethylated in NSCs, which permits their progression along the neurogenic lineage.
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Really cool approach to study combinatorial alterations on tumor phenotypes! Check it out 👇
0/ Preprint alert! 🚨
One step closer to solving the genotype ➡ phenotype puzzle in cancer! Led by @BreinigMarco, @LomakinAI, and @HeidariElyas, our novel approach, #CHOCOLAT_G2P 🍫, deciphers the impact of combinatorial alterations on tumor phenotypes and their environment.
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Incredibly grateful and honored to receive the Hella Bühler prize! So helpful for young labs. Thank you so much for supporting our research 🙏
Her outstanding research on the biology of soft-tissue sarcomas, a kind of tumor occurring in particular with children and young adults, has earned Ana Banito the Hella Bühler Prize. 👏👏 @KiTZ_HD @UniHeidelberg
➡️ t1p.de/rvpj5
Congratulations @NsBenab! So well deserved 🤩
💫 Herzlichen Glückwunsch an die sechs Preisträgerinnen und -träger des #Nachwuchspreis|es der Nationalen Dekade gegen Krebs! 💫
Sie alle leisten hervorragende Arbeit in der #Onkologie. Wir sind gespannt und freuen uns, Ihren Weg weiter begleiten zu dürfen. 💐 🏆
#XgegenKrebs
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Honored and incredibly grateful to @EMBO for being included in these amazing group of young investigators. This is only possible because of my amazing team 🙌 and support from @KiTZ_HD @DKFZ
26 scientists have been selected to join the EMBO Young Investigator Programme @embo_yip, an initiative that supports excellent young group leaders in the early stages of their independent careers
embo.org/press-releases/embo…
Excited to share that our paper is out @NatureSMB. Spearheaded by the amazing @NsBenab who is starting her own lab next year 🤩. We show that the SSX C tail of SSX oncofusions provides specificity to H2AK119ub1-rich regions and further promotes PRC1.1 complex stability.
Huge thanks to all involved including, T. Michael Underhill, Torsten Nielsen, @fjsanchezrivera. @DimitrisTypas, all NSMB editorial team and reviewers for handling our paper and making it better. rdcu.be/dmJmA
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Thank you SFA!
SFA is pleased to announce the recipients of our 2023 Research Grants. Twelve grants, each worth $50,000, have been awarded to researchers who have made it their mission to study #sarcoma: curesarcoma.org/grant/ #cancer #CureSarcoma
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Join the discussion with this amazing panel!
Today at 1pm. Details below.
Happy international women's day to all the amazing women I have/had the privilege to work with
#WomenInScience
Today we celebrate #InternationalWomensDay! Under the 2023 campaign theme #EmbraceEquity, we are hosting a panel discussion at DKFZ about #WomenInScience. Join us today, 1 - 2 pm, in the DKFZ communication center or online via Zoom:
➡️ bit.ly/3ZMNciF Code: 07131100
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If you are looking for a position don’t miss this chance 👇
I’m delighted to announce two major developments for my career:
First, I will be joining the amazing @VHIO as a Group Leader!
Second, I have been awarded an #ERCStG (MACHETE!) to start my lab @ERC_Research.
I look forward to join the vibrant Barcelona research community!
TLR2 mediates oncogene-induced senescence and the SASP in early lung tumors 👇. Great work! Congratulations to all authors
Our data shows that: TLR2 is associated with improved survival and premalignant regression in human lung cancer; that TLR2 mediates oncogene-induced senescence and the SASP in early lung tumors; that TLR2 SASP recruits myeloid cells and promotes senescence surveillance;
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Check it out! #MACHETE strategy for modeling large genomic deletions👇
Now out in @NatureCancer, an updated version of our study developing the #MACHETE strategy for modeling large genomic deletions and using it to uncover a key role for type I #IFN deletions in tumor #ImmuneEvasion & #Metastasis: nature.com/articles/s43018-0… (1/3)
Congratulations to Dr. Dalal for an amazing defense today! First student graduating from the lab and I could not be prouder 🍾🤩
So proud of our first lab preprint! Feeling blessed for having such exceptional people in the lab @NsBenab, and thankful for all collaborators who helped make it happen.
@DKFZ @KiTZ_HD #Sarcoma #Polycomb
biorxiv.org/content/10.1101/…
Beautiful article
This weekend is my great-uncle's Centennial.
His story is remarkable - born in a village of <100 people, mostly illiterate, dodging Partition, to @NobelPrize for cracking the genetic code & synthesizing the first artificial gene.
dawn.com/news/1668120
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