Tendon-enthusiasts! Putting the FUN in structure-FUNction! (Student-run account... in case it was not painfully obvious)
Philadelphia, PA
Joined March 2018
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Catching up on reading this Sunday? Check out the Lou Lab's latest papers focused on minor collagens in tendon development and healing for some interesting and surprising stories!
Tendon-Targeted Knockout of Collagen XII Disrupts Murine Achilles Tendon Structure, Function, and Gene Expression at Later Stages of Postnatal Development: pubmed.ncbi.nlm.nih.gov/4191…
Loss of Type III Collagen has Limited Effect on Tendon Healing in Young Adult Mice: pubmed.ncbi.nlm.nih.gov/4210…
Soslowsky Lab retweeted
Reminder to join our next ORS Tendon Section Webinar on Wednesday!
Register now for an @ors_tendon #WebinarWednesday on Sept 24, 12 PM CST, A Tendon-cy to Heal: Regenerating Tendons & Ligaments in Zebrafish. Hear from Thomas Schilling, Jenna Galloway & Joanna Smeeton on the latest #tendon & ligament regeneration. 🔗ors.memberclicks.net/ten0924…
Attention glycosaminoglycan afficionados! Be sure to check out @BlankJonathon's latest paper on GAG depletion in the Achilles Tendon! pubmed.ncbi.nlm.nih.gov/4085…
Mark your calendars for this Tendon Section Webinar organized by our Kappa Delta King, @DymentLabPenn! See y'all on 9/24!
Register now for an @ors_tendon #WebinarWednesday on Sept 24, 12 PM CST, A Tendon-cy to Heal: Regenerating Tendons & Ligaments in Zebrafish. Hear from Thomas Schilling, Jenna Galloway & Joanna Smeeton on the latest #tendon & ligament regeneration. 🔗ors.memberclicks.net/ten0924…
Check out this PTHr-Pretty cool work by friend of the Lou Lab, Wonsae!
🦴 Does lactation strengthen or weaken the skeleton? Check out this
@ORSsociety Basic Science Tip to learn how elevated PTHrP shrinks both bone & marrow fat, while PTH1R signalling worsens bone loss, revealing new hormonal control of maternal bone health.
ors.org/basic-science-tips/#…
HUGE congrats to the Lou Lab's newest PhD, Mike DiStefano, on his successful defense today! #GymTanTendie
Huge news for the the #inSTRONG community.
Microsoft support for Windows 10 Pro ends on October 14, 2025. Is your lab prepared for the transition to Windows 11? Our latest blog post discusses how and why to migrate your testing systems: go.instron.com/46MNv3O
Looking for a fun Monday night activity to fill the Love Island-sized hole in your heart? Check out the Lou Lab's latest paper on age-related changes in the supraspinatus tendon: pubmed.ncbi.nlm.nih.gov/4057…
#(Rotator)CuffingSeason
You (bigly)can't miss the chance to be (decor)in the know about all things SLRPs and tendon healing! Check out this paper from Christelle and the Lou Lab team!
A serious injury to aging tendons often means a slower, less complete recovery – one that science is still trying to fully understand.
Researchers used a preclinical model of aging to investigate how two key proteins, decorin and biglycan, influence tendon healing. Using a controlled knockdown approach, they assessed structural, genetic, and mechanical outcomes across early and late healing stages. They found:
🔹 When removed early, decorin knockdown appeared to improve recovery of viscoelastic properties.
🔹 Biglycan deficiency delayed initial healing but didn’t impair final mechanical strength.
🔹 Collagen fibril architecture changed, yet quasi-static strength measures were unaffected.
These findings suggest subtle, protein-level interventions may help aged tendons heal smarter, not just stronger.
𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10…
𝗦𝘁𝘂𝗱𝘆: Decorin Knockdown Improves Aged Tendon Healing by Enhancing Recovery of Viscoelastic Properties, While Biglycan May Not
𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Christelle Darrieutort-Laffite, Stephanie N. Weiss, Courtney A. Nuss, Joseph B. Newton, Jeremy D. Eekhoff, and Louis J. Soslowsky
@Penn
@PennMedicine
@McKayLaboratory
@PennEngineers
@pennbioeng
@SoslowskyLab
@CHUnantes
@Inserm
𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…
And BIG CONGRATS to our #TendieFriendie and #BoerckelLabBestie, Elizabeth (@ESeidlScience of @jboerckel lab), who won the best poster award!
Jon (@blankjonathon) represented the Lou Lab at @PennOrtho Research Day, discussing efforts to generate overuse tendinopathy models through the @upenn_pat_cort!
As the kids say… run it back 🏃♀️
The @SoslowskyLab are at it again, showing that 16 weeks high-speed running does not induce #Achilles #tendinopathy in rats. Do rats have better post-exercise recovery than humans. Can we learn anything from that to improve human tendon recovery? journals.physiology.org/doi/…
The Real Collagens of Tendon Healing (also known as @Maggie_Tamburro's defense) is coming to a big screen near you!
Thursday, 5/15, at 10:00 AM EST; DM for Zoom info!
ALT Picture of the Real Housewives of New York holding collagen molecules
We love to see veterinarian-scientist representation! Check out this Collagen 5-focused work from Lou Lab alum, Dr. Carlson!
Patients w/ Ehlers-Danlos Syndrome (cEDS) present w/ extensible skin & joint instability, with more females affected.
In a mouse model of cEDS, Vet-Scientist @jaclynacarlson discovered altered healing in this population.
Link: buff.ly/crnkIwN
#ORSSMC #ORSxDerby
