News from the Sternberg lab at Columbia Univ., HHMI. Posts are from lab members and not Samuel Sternberg unless signed SHS. Posts represent personal views only.
New York, NY
Joined October 2017
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1/7 Last week the Sternberg Lab welcomed ~40 junior & senior high school AP Research students from the East Meadow school district (and their incredible teachers) into our lab at Columbia University.
1/5 Telomerase has long been linked to chromosome maintenance in eukaryotes. Now, we show that telomerase-like activity is also present in bacteria, shedding new light on its ancient origins.
Excited to share that our work on DRT10 is now out in @Nature!
nature.com/articles/s41586-0…
4/5 DRT10 biochemistry and structure (with @IsraelF96135088): xitter.cf/SternbergLab/status/20…
1/11 New preprint from the Sternberg lab in collaboration with the Fernández lab! We are excited to share our structure-function study of DRT10, a bacterial defense-associated reverse transcriptase that synthesizes long tandem-repeat DNA.🧵
More here: biorxiv.org/content/10.64898…
1/2 Here we report the activity of Arc, a 50-aa DNA-binding protein encoded within IS605-family transposons. biorxiv.org/content/10.64898…
1/13 — New pre-print from the Sternberg Lab in collaboration with Leifu Chang's Lab! TnpB nucleases have repeatedly given rise to TldRs, nuclease-dead RNA-guided transcription factors. Here we define the biological role of a TldR clade in its native host.
biorxiv.org/content/10.64898…
12/13 — TldR is a naturally evolved parallel to engineered CRISPRi. Repression of an OppA variant shifts the relative contribution of remaining paralogs, which could influence which peptides a cell imports. What induces TldR natively remains unknown.
biorxiv.org/content/10.64898…
