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Tom

@TListerChem

MSCA fellow Piel lab ETH Zürich Formerly PDRA @GreenGroupMIB PhD @GreenGroupMIB + @LarrosaGroup

 Manchester, England
Joined January 2020
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Photo by Tom (@TListerChem)
The story of how I developed the first biocatalysts for convergent and stereoselective SNAr chemistry is out now in @Nature! A massive thank you to all of the contributing authors from @GreenGroupMIB and @LarrosaGroup 🤓 nature.com/articles/s41586-0…
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Protein-confined imidazolium intermediates enable diverse biocatalytic C–C and C–N bond formations dlvr.it/TTndDk
Image from Nature Catalysis (@NatureCatalysis)
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Enantiodivergent Access to Acyclic Quaternary Stereocenters by Nitrilase-Catalyzed Desymmetrizing Hydrolysis of Malononitriles | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Enantiodivergent Access to Acyclic Quaternary Stereocenters by Nitrilase-Catalyzed Desymmetrizing...

Enantiodivergent Access to Acyclic Quaternary Stereocenters by Nitrilase-Catalyzed Desymmetrizing...

Abstract. The desymmetrization of fully substituted carbons bearing a pair of enantiotopic functional groups represents a pragmatic approach to the synthes

pubs.acs.org
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Very happy to announce that 'Efficient and selective energy transfer photoenzymes powered by visible light' is out today in Nature Chemistry! Congratulations to Rebecca, Ross and everyone else involved in this project! 🎉🎉🎉 nature.com/articles/s41557-0…
Efficient and selective energy transfer photoenzymes powered by visible light

Efficient and selective energy transfer photoenzymes powered by visible light

Nature Chemistry - Recent studies have shown that energy transfer photoenzymes can be engineered to promote stereocontrolled [2 + 2] cycloadditions; however, existing systems rely on...

nature.com
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KFB Lab Alert: Our latest work applying enzymatic halide recycling to thioketal cleavage is now available @ChemRxiv! Congratulations to @ManiksharmaASR and Yue Li on this work! chemrxiv.org/engage/chemrxiv…
Image from Kyle F. Biegasiewicz (@KFBChem)
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Photoredox-Catalyzed Nucleophilic Aromatic Substitution of Halophenols with Azoles via Oligomeric Phenylene Oxide Radicals | Journal of the American Chemical Society @TotalSyntheses @PrincetonChem @Princeton pubs.acs.org/doi/10.1021/jac…
Photoredox-Catalyzed Nucleophilic Aromatic Substitution of Halophenols with Azoles via Oligomeric...

Photoredox-Catalyzed Nucleophilic Aromatic Substitution of Halophenols with Azoles via Oligomeric...

Abstract. Nucleophilic aromatic substitution (SNAr) reactions are widely employed in organic synthesis yet typically require the use of electron-deficient

pubs.acs.org
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Just out in @JACS, we report mechanistic studies on the photoexcitation of biscyclometalated-Ru species and their role in photocatalyzed C-H alkylations with epoxides. Congratulations to Kurt and co-workers, @Team_Natrajan and Golovanov group!! pubs.acs.org/doi/10.1021/jac…
Bis-Cycloruthenated Complexes in Visible Light-Induced C–H Alkylation with Epoxides

Bis-Cycloruthenated Complexes in Visible Light-Induced C–H Alkylation with Epoxides

Abstract. Bis-cycloruthenated complexes (BCRCs) of the type [Ru­(N^C)2L2] are proposed to be key reactive intermediates in the Ru­(II)-catalyzed directed C

pubs.acs.org
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#ProcterPOW: our colleagues @GreenGroupMIB report an enzymatic enantioselective SNAr to give a variety of products and building enantiopure quat centres. Engineering 🧬 of the active site leads to a 31-fold increase in conv and 91% increase in ee! 🔗👇
Image from Procter Group (@GroupProcter)
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Delighted to announce that 'Engineered enzymes for enantioselective nucleophilic aromatic substitutions' is out now in Nature! Congratulations to Tom, George and everyone else involved in this project! 🎉🎉🎉 nature.com/articles/s41586-0…
Engineered enzymes for enantioselective nucleophilic aromatic substitutions

Engineered enzymes for enantioselective nucleophilic aromatic substitutions

Nature - A biocatalytic approach to enantioselective nucleophilic aromatic substitution (SNAr) was achieved through laboratory evolution of highly efficient and selective SNArase biocatalysts.

nature.com
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We are so excited to share our collaborative work with the @GreenGroupMIB, on the development of biocatalysts for enantioselective SNAr reactions, just out in @Nature!! Massive congrats to Tom, @TListerChem, and all co-workers! 👏 See: rdcu.be/d6moS
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Image from The Nobel Prize (@NobelPrize)
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📢 Finally out in @J_A_C_S: We engineered the first #PhotoLanZyme, a lanthanide-dependent photoredox enzyme that catalyzes radical C-C bond cleavages upon visible-light irradiation! 💡🧫🧪🧬💻 @TU_Muenchen @ERC_Research pubs.acs.org/doi/10.1021/jac…
A De Novo Metalloenzyme for Cerium Photoredox Catalysis

A De Novo Metalloenzyme for Cerium Photoredox Catalysis

Abstract. Cerium photoredox catalysis has emerged as a powerful strategy to activate molecules under mild conditions. Radical intermediates are formed usin

pubs.acs.org
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Today we're joined by Gillian McArthur (Larrossa group), who shares the incredible story behind the development of an air and moisture stable catalyst, RuAqua!! Link: youtu.be/g2xHSLJIO8U Key paper: @NatureChemistry doi.org/10.1038/s41557-024-0…
Image from Synthesis Workshop (@MatthewHorwitz1)
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Arguably the coolest chemistry we’ve uncovered yet @ChemRxiv, especially given that it’s with just one metal!! 🤯Fantastic work by @stas_chem and first of many collabs with @baikkaist | Hydride as a Leaving Group in Nucleophilic Aromatic Substitution | - go.shr.lc/3ycdkeL
Image from Daniel Broere (@BroereDaniel)
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Excited to share our Chem Rev article! Here we describe how site specific incorporation of non-canonical amino acids has enabled mechanistic studies, improved existing functions & provided a strategy for embedding new modes of catalysis into active sites pubs.acs.org/doi/10.1021/acs…
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Replying to @LarrosaGroup
@LarrosaGroup in Bristol Synthesis Meeting! Amazing day with 5 Top level speakers
Image from PabloDincht (@PabloDincht)
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🚀Exciting PhD opportunity alert! Dive into ground breaking research with a Oct 2024 start. We're exploring innovative synthetic chemistry on-DNA🧬for DNA-encoded libraries. Transform the future of chemistry! Deadline 15 March 2024. Details: tinyurl.com/4f3d8f66 #PhDPosition
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A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme nature.com/articles/s41467-0…
Image from Chemistry News (@ChemistryNews)
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🎉The Blavatnik Awards and @nyasciences are excited to announce the Honourees of the 2024 Blavatnik Awards in the UK! Please join us in congratulating these nine incredible scientists sparking innovations that will transform our future world. Learn more: blavatnikawards.org/news/ite…
Image from Blavatnik Awards (@BlavatnikAwards)
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Starting off the year with some exciting news! Thrilled to say my first ever cover art is on the cover of Chemical Reviews this month! Our review was submitted as part of a thematic issue about late stage functionalisation, go check it out if you haven't already :) @LarrosaGroup
Image from Gillian McArthur 🏴󠁧󠁢󠁳󠁣󠁴󠁿 (@GillianMcArth10)
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