Tao Liming (@Taoliming) header
Tao Liming (@Taoliming) profile picture

Tao Liming

@Taoliming

single cell genomics, cell lineage tracing in development and cancer evolution

 San Francisco
Joined May 2009
  • Tweets39
  • Following314
  • Followers89
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Photo by Tao Liming (@Taoliming)
Too little MECOM causes bone marrow failure, too much -> AML, Well put! @RichardVoit
Richard Voit (@RichardVoit) profile pictureRichard Voit@RichardVoit15 Dec 2022
Too little MECOM causes bone marrow failure, too much -> AML. We wondered why. Turns out that MECOM (and friends) finely tunes the expression of an essential HSC transcriptional network that gets hijacked in leukemia. Proud of our whole team: nature.com/articles/s41590-0…
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Wonderful to have our paper on a MECOM-regulated gene network in human hematopoietic stem cell maintenance and leukemia published in @NatImmunol! Terrific work from our group led by @RichardVoit, @Taoliming, and @fulong_yu: nature.com/articles/s41590-0…
Image from Vijay Sankaran (@bloodgenes)
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The Smillie Lab opens March at @MGHMedicine! We develop methods (wet/dry) to understand microbial life on the human body #microbiome #singlecell #evolution #deeplearning. Hiring grad students, postdocs, and RAs @harvardmed @broadinstitute. Please share! smillielab.org

SMILLIE LAB

smillielab.org
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A new imaging method follows young neurons in a developing zebrafish as they travel across the embryo and organize themselves into circuits. Read the latest work from Philipp Keller’s lab, published today in @CellCellPress. janelia.org/news/how-neural-…
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MIT Biology (@MITBiology) profile pictureMIT Biology@MITBiology26 Jul 2018
In this Technology Feature from Nature, Chris Burge @daSpliceIsRight discusses what it takes to turn a sequencer into a high-throughput instrument measuring protein–DNA interactions: go.nature.com/2JRJKMx
Image from MIT Biology (@MITBiology)
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Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed go.nature.com/2JOBmST
Image from Nature Biotechnology (@NatureBiotech)
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Cell (@CellCellPress) profile picture
Cell@CellCellPress7 Jun 2018
New tool alert! Development of intron seqFISH allows in situ profiling and visualization of nascent #transcription at the #single_cell level, revealing spatial and temporal features of the nascent transcriptome cell.com/cell/abstract/S0092… @LongCai_Lab @Caltech #techdev
Image from Cell (@CellCellPress)
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Lior Pachter (@lpachter) profile picture
Lior Pachter@lpachter6 May 2018
Supp Fig 3. shows an 8 sample (some human, some mouse, some mixed) multiplexed experiment. The color gradients hint at an exciting finding, namely that tag # is a proxy for cell size, thus opening up the possibility of a new mode of single-cell measurement along w/ scRNA-Seq.
Image from Lior Pachter (@lpachter)
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See how the #openscience cell lines and plasmids that are available through our #AllenCellCollection can help researchers to see inside of healthy human cells with unprecedented clarity. #Crispr

Inside the Allen Cell Collection

The Allen Cell Collection allows researchers to see inside of human cells with unprecedented clarity, and better understand what makes our cells healthy and what goes wrong in disease.

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Our new FateID method predicts lineage probabilities in stem cells from subtle transcriptome modulations - going beyond clustering! It enabled the discovery of a common progenitor population of B cells and pDCs! teapaw.org/naturemethods/status/9…
Nature Methods (@naturemethods) profile pictureNature Methods@naturemethods9 Apr 2018
FateID uses #singlecell expression data to find early fate biases in multipotent progenitors. Also featuring robotic, miniaturized mCEL-seq2 and improved clustering using RaceID3 bit.ly/2qhHOpp
Image from Nature Methods (@naturemethods)
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Intra-tumour diversification in colorectal cancer at the single-cell level nature.com/articles/s41586-0…
Image from Nicolas Robine (@notSoJunkDNA)
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Tao Liming retweeted
Sorek Lab (@SorekLab) profile picture
Sorek Lab@SorekLab24 Mar 2018
Protein-Injection Machines in Bacteria sciencedirect.com/science/ar… Review by Jorge Galan & Gabriel Waksman
Image from Sorek Lab (@SorekLab)
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Karen Miga (@khmiga) profile picture
Karen Miga@khmiga19 Mar 2018
I am proud to announce the first linear map of a human Y chromosome centromere is now published. rdcu.be/JnIO. Congratulations @mitenjain @HOlsenUCSC @AkesonUCSC @hwillardX @BenedictPaten @nanopore @ucscgenomics @ucsc_nanopore
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Skin color “is not a binary trait,” @genetisaur notes in @NatGeoMag article. “It’s a quantitative trait, and everyone has some gradient on this spectrum.” fal.cn/4Ypg
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Our approach to making single-cell RNAseq more affordable and high-throughput is out: science.sciencemag.org/conte… Fantastic work by @dna_rosenberg @RocoCharlie @annabiosys @SMukherjee89 @paul_sample_ and collaborators @AllenInstitute and Pun lab.
Image from Georg Seelig (@seeliglab)
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We are deeply saddened to announce the death of Professor Sir John Sulston, founding director of the Wellcome Sanger Institute. He was a great scientific visionary and leader who made historic contributions to science.
Image from Wellcome Sanger Institute (@sangerinstitute)
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Possibly another RNA disease=> nature.com/articles/s41588-0… Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy
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Bozhi Tian (@uchicagomed) has created microscopic nanowires that can be inserted into neurons and hit with light to produce electrical impulses which provides a way for researchers to better understand how electrical signals work in the brain. #NIHHighRisk go.usa.gov/xnujf
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Finally getting caught up on paper reading. The human brain organoid folding study (with help from @jacob_hanna) is incredible. The supplemental video alone is worth a watch (or five...or ten). Look at that interkinetic nuclear migration!
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Tao Liming retweeted
Eran Segal (@segal_eran) profile picture
Eran Segal@segal_eran2 Mar 2018
Wow, this is a new low: Just got rejected from biorxiv... @cshperspectives We wrote a review related to a paper we just published and were hoping to have it out with the paper... but apparently @biorxivpreprint doesn’t publish reviews... Why?!? What to do? Post on our lab site??
Image from Eran Segal (@segal_eran)
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